SMPDB_ID

SMP0000280

PW_ID

PW000302

图片

主题

Drug Action

描述

Alteplase is the generic version of the drugs Activase and Actilyse. It is a thrombolytic drug prescribed to treat acute myocardial infarctions and other blood clotting conditions. Alteplase if often used to treat ischaemic stroke within hours of onset. The drug acts by breaking up blood clots. Alteplase binds fibrin in the blood clot to converts plasminogen to plasmin. Plasmin is a proteolytic enzyme that causing the degradation of fibrin. A side effect of the drug is bleeding, angioedema, allergic reactions and fever.

代谢物

SMPDB ID	代谢物id	代谢物的名字
SMP0000280	PW_C002089	Reduced Vitamin K (phylloquinone)
SMP0000280	PW_C001746	Vitamin K1 2,3-epoxide
SMP0000280	PW_C000353	Calcium
SMP0000280	PW_C000009	Cortexolone

蛋白质

SMPDB ID	蛋白质id	蛋白质的名字
SMP0000280	P38435	Vitamin K-dependent gamma-carboxylase
SMP0000280	Q9BQB6	Vitamin K epoxide reductase complex subunit 1
SMP0000280	P13726	Tissue factor
SMP0000280	P08709	Coagulation factor VII
SMP0000280	P00750	Tissue-type plasminogen activator
SMP0000280	P05160	Coagulation factor XIII B chain
SMP0000280	P00488	Coagulation factor XIII A chain
SMP0000280	P02679	Fibrinogen gamma chain
SMP0000280	P02675	Fibrinogen beta chain
SMP0000280	P02671	Fibrinogen alpha chain
SMP0000280	P00742	Coagulation factor X
SMP0000280	P12259	Coagulation factor V
SMP0000280	P00734	Prothrombin
SMP0000280	P00451	Coagulation factor VIII
SMP0000280	P00740	Coagulation factor IX
SMP0000280	P03951	Coagulation factor XI
SMP0000280	P03952	Plasma kallikrein
SMP0000280	P02452	Collagen alpha-1(I) chain
SMP0000280	P00748	Coagulation factor XII
SMP0000280	P00747	Plasminogen
SMP0000280		Alteplase