Glucose Transporter Defect (SGLT2),小分子通路数据库

Glucose Transporter Defect (SGLT2)

SMPDB_ID

SMP0000184

PW_ID

PW000216

图片

主题

Disease

描述

The major reabsorptive mechanism for D-glucose in the kidney is known to involve a lower affinity, high capacity Na()/glucose cotransporter, which is located in the early proximal convoluted tubule segment S1 and has a Na()-to-glucose coupling ratio of 1:1. This defect causes massive accumulation of glucose in the urine, and symptoms include glucosuria.

代谢物

SMPDB ID	代谢物id	代谢物的名字
SMP0000184	PW_C000448	L-Cysteine
SMP0000184	PW_C000026	Aldosterone
SMP0000184	PW_C000463	Hydrogen carbonate
SMP0000184	PW_C000200	Urea
SMP0000184	PW_C001420	Water
SMP0000184	PW_C000457	Potassium
SMP0000184	PW_C000458	Sodium
SMP0000184	PW_C000374	Chloride ion

蛋白质

SMPDB ID	蛋白质id	蛋白质的名字
SMP0000184	Q15849	Urea transporter 2
SMP0000184	P82251	B(0,+)-type amino acid transporter 1
SMP0000184	Q07837	Neutral and basic amino acid transport protein rBAT
SMP0000184	P08235	Mineralocorticoid receptor
SMP0000184	Q92536	Y+L amino acid transporter 2
SMP0000184	Q9UM01	Y+L amino acid transporter 1
SMP0000184	Q969I6	Sodium-coupled neutral amino acid transporter 4
SMP0000184	Q9NP91	Sodium- and chloride-dependent transporter XTRP3
SMP0000184	Q01650	Large neutral amino acids transporter small subunit 1
SMP0000184	P08195	4F2 cell-surface antigen heavy chain
SMP0000184	Q9UHI5	Large neutral amino acids transporter small subunit 2
SMP0000184	P43005	Excitatory amino acid transporter 3
SMP0000184	P51170	Amiloride-sensitive sodium channel subunit gamma
SMP0000184	P51172	Amiloride-sensitive sodium channel subunit delta
SMP0000184	P51168	Amiloride-sensitive sodium channel subunit beta
SMP0000184	P37088	Amiloride-sensitive sodium channel subunit alpha
SMP0000184	Q92482	Aquaporin-3
SMP0000184	P41181	Aquaporin-2
SMP0000184	O15244	Solute carrier family 22 member 2
SMP0000184	Q9UHW9	Solute carrier family 12 member 6
SMP0000184	Q4U2R8	Solute carrier family 22 member 6
SMP0000184	Q13621	Solute carrier family 12 member 1
SMP0000184	P29972	Aquaporin-1
SMP0000184	P51800	Chloride channel protein ClC-Ka
SMP0000184	P54710	Sodium/potassium-transporting ATPase subunit gamma
SMP0000184	B7ZKV8	ATPase, (Na+)/K+ transporting, beta 4 polypeptide
SMP0000184	P54709	Sodium/potassium-transporting ATPase subunit beta-3
SMP0000184	P14415	Sodium/potassium-transporting ATPase subunit beta-2
SMP0000184	P05026	Sodium/potassium-transporting ATPase subunit beta-1
SMP0000184	Q13733	Sodium/potassium-transporting ATPase subunit alpha-4
SMP0000184	P13637	Sodium/potassium-transporting ATPase subunit alpha-3
SMP0000184	P50993	Sodium/potassium-transporting ATPase subunit alpha-2
SMP0000184	P05023	Sodium/potassium-transporting ATPase subunit alpha-1
SMP0000184	P55017	Solute carrier family 12 member 3

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