SMPDB_ID

SMP0000336

PW_ID

PW000210

图片

主题

Disease

描述

Vitamin A deficiency can be caused by many causes. A defect in the BCMO1 gene which codes for beta,beta-carotene 15,15’-monooxygenase is one of them. Beta,beta-carotene 15,15’-monooxygenase catalyzes the chemical reaction where the two substrates are beta-carotene and O2, whereas its product is retinal. A defect in this enzyme results in decrease of levels of retinal and vitamin A in serum; Signs and symptoms include night blindness, poor adaptation to darkness, dry skin and hair.

代谢物

SMPDB ID	代谢物id	代谢物的名字
SMP0000336	PW_C007978	all-trans-5,6-Epoxyretinoic acid
SMP0000336	PW_C007979	all-trans-18-Hydroxyretinoic acid
SMP0000336	PW_C002706	4-oxo-Retinoic acid
SMP0000336	PW_C002690	4-Hydroxyretinoic acid
SMP0000336	PW_C001786	Retinoyl b-glucuronide
SMP0000336	PW_C007207	All-trans-13,14-dihydroretinol
SMP0000336	PW_C001799	Heme
SMP0000336	PW_C007859	4-Oxoretinol
SMP0000336	PW_C001227	all-trans-Retinoic acid
SMP0000336	PW_C001600	9-cis-Retinoic acid
SMP0000336	PW_C002667	9-cis-Retinal
SMP0000336	PW_C001065	Oxygen
SMP0000336	PW_C000437	B-Carotene
SMP0000336	PW_C002666	9-cis-Retinol
SMP0000336	PW_C029134	TG(16:1(9Z)/22:0/16:1(9Z))
SMP0000336	PW_C003195	DG(16:1(9Z)/22:0/0:0)
SMP0000336	PW_C000209	Vitamin A
SMP0000336	PW_C000544	Fe2+
SMP0000336	PW_C001420	Water
SMP0000336	PW_C001935	Retinyl ester
SMP0000336	PW_C001099	Coenzyme A
SMP0000336	PW_C000940	Acetyl-CoA
SMP0000336	PW_C000059	Glycerophosphocholine
SMP0000336	PW_C001948	Retinyl palmitate
SMP0000336	PW_C004838	PC(24:1(15Z)/15:0)
SMP0000336	PW_C002665	11-cis-Retinol
SMP0000336	PW_C000146	NADPH
SMP0000336	PW_C000143	NADP
SMP0000336	PW_C009795	Zinc
SMP0000336	PW_C001144	NADH
SMP0000336	PW_C001048	Retinal
SMP0000336	PW_C000721	NAD
SMP0000336	PW_C001448	11-cis-Retinaldehyde

蛋白质

SMPDB ID	蛋白质id	蛋白质的名字
SMP0000336	Q9HB55	Cytochrome P450 3A43
SMP0000336	P20815	Cytochrome P450 3A5
SMP0000336	P08684	Cytochrome P450 3A4
SMP0000336	P24462	Cytochrome P450 3A7
SMP0000336	P20813	Cytochrome P450 2B6
SMP0000336	Q16696	Cytochrome P450 2A13
SMP0000336	P20853	Cytochrome P450 2A7
SMP0000336	P11509	Cytochrome P450 2A6
SMP0000336	P30040	Endoplasmic reticulum resident protein 29
SMP0000336	P22309	UDP-glucuronosyltransferase 1-1
SMP0000336	Q9HCN8	Stromal cell-derived factor 2-like protein 1
SMP0000336	P23284	Peptidyl-prolyl cis-trans isomerase B
SMP0000336	Q15084	Protein disulfide-isomerase A6
SMP0000336	P13667	Protein disulfide-isomerase A4
SMP0000336	Q13087	Protein disulfide-isomerase A2
SMP0000336	Q6IN67	HYOU1 protein
SMP0000336	P11021	78 kDa glucose-regulated protein
SMP0000336	Q96GW1	HSP90B1 protein
SMP0000336	Q9UBS4	DnaJ homolog subfamily B member 11
SMP0000336	Q6NUM9	All-trans-retinol 13,14-reductase
SMP0000336	O43174	Cytochrome P450 26A1
SMP0000336	O94788	Retinal dehydrogenase 2
SMP0000336	P00352	Retinal dehydrogenase 1
SMP0000336	Q9HAY6	Beta,beta-carotene 15,15'-monooxygenase
SMP0000336	P41247	Patatin-like phospholipase domain-containing protein 4
SMP0000336	Q16518	Retinoid isomerohydrolase
SMP0000336	O75907	Diacylglycerol O-acyltransferase 1
SMP0000336	Q58HT5	Acyl-CoA wax alcohol acyltransferase 1
SMP0000336	O95237	Lecithin retinol acyltransferase
SMP0000336	Q8TC12	Retinol dehydrogenase 11
SMP0000336	Q9BPW9	Dehydrogenase/reductase SDR family member 9
SMP0000336	O75911	Short-chain dehydrogenase/reductase 3
SMP0000336	Q9NYR8	Retinol dehydrogenase 8
SMP0000336	O75452	Retinol dehydrogenase 16
SMP0000336	Q9BTZ2	Dehydrogenase/reductase SDR family member 4
SMP0000336	Q96NR8	Retinol dehydrogenase 12
SMP0000336	P07327	Alcohol dehydrogenase 1A