SMPDB_ID

SMP0000094

PW_ID

PW000136

图片

主题

Drug Action

描述

Sulindac is a non-steroidal anti-inflammatory drug (NSAID). Like most NSAIDs, sulindac is a non-selective prostaglandin G/H synthase (a.k.a. cyclooxygenase or COX) inhibitor that acts on both prostaglandin G/H synthase 1 and 2 (COX-1 and -2). COX catalyzes the conversion of arachidonic acid to prostaglandin G2 and prostaglandin G2 to prostaglandin H2. Prostaglandin H2 is the precursor of a number of prostaglandins involved in fever, pain, swelling and inflammation. The analgesic, antipyretic and anti-inflammatory effects of sulindac occurs as a result of decreased prostaglandin synthesis.

代谢物

SMPDB ID	代谢物id	代谢物的名字
SMP0000094	PW_C040708	2,3-Dinor-8iso prostaglandin F2alpha
SMP0000094	PW_C040709	2,3-Dinor-8iso prostaglandin F1alpha
SMP0000094	PW_C006388	LysoPC(14:0/0:0)
SMP0000094	PW_C003933	PC(14:0/20:4(5Z,8Z,11Z,14Z))
SMP0000094	PW_C040452	12(S)-HETE
SMP0000094	PW_C008524	12-KETE
SMP0000094	PW_C040453	12(R)-HETE
SMP0000094	PW_C002105	12(S)-HPETE
SMP0000094	PW_C002614	20-Hydroxyeicosatetraenoic acid
SMP0000094	PW_C002163	8-Isoprostane
SMP0000094	PW_C002171	8-HETE
SMP0000094	PW_C002179	12(R)-HPETE
SMP0000094	PW_C006775	19(S)-HETE
SMP0000094	PW_C002183	8(S)-HPETE
SMP0000094	PW_C001579	5,6-DHET
SMP0000094	PW_C001477	5,6-Epoxy-8,11,14-eicosatrienoic acid
SMP0000094	PW_C001561	8,9-DiHETrE
SMP0000094	PW_C001511	8,9-Epoxyeicosatrienoic acid
SMP0000094	PW_C001814	Prostaglandin G2
SMP0000094	PW_C000353	Calcium
SMP0000094	PW_C006774	5-HPETE
SMP0000094	PW_C001562	11,12-DiHETrE
SMP0000094	PW_C002170	11,12-Epoxyeicosatrienoic acid
SMP0000094	PW_C000423	Magnesium
SMP0000094	PW_C001529	14,15-DiHETrE
SMP0000094	PW_C002113	14,15-Epoxy-5,8,11-eicosatrienoic acid
SMP0000094	PW_C002172	16(R)-HETE
SMP0000094	PW_C002174	11,12,15-THETA
SMP0000094	PW_C002389	15H-11,12-EETA
SMP0000094	PW_C002181	11,14,15-THETA
SMP0000094	PW_C002180	11H-14,15-EETA
SMP0000094	PW_C008133	Fe3+
SMP0000094	PW_C000821	Arachidonic acid
SMP0000094	PW_C002104	11-Dehydro-thromboxane B2
SMP0000094	PW_C002099	Prostaglandin B2
SMP0000094	PW_C001820	Thromboxane B2
SMP0000094	PW_C040451	Prostaglandin-c2
SMP0000094	PW_C001699	Prostaglandin A2
SMP0000094	PW_C000889	Prostaglandin F2a
SMP0000094	PW_C000949	Prostaglandin E2
SMP0000094	PW_C001121	Thromboxane A2
SMP0000094	PW_C006776	11-Epi-PGF2a
SMP0000094	PW_C001068	Prostaglandin H2
SMP0000094	PW_C001084	Prostaglandin D2
SMP0000094	PW_C001028	Prostaglandin I2
SMP0000094	PW_C001687	Prostaglandin J2
SMP0000094	PW_C006229	5-KETE
SMP0000094	PW_C006773	5-HETE
SMP0000094	PW_C002103	6-Ketoprostaglandin E1
SMP0000094	PW_C001726	6-Keto-prostaglandin F1a
SMP0000094	PW_C002398	15-Deoxy-d-12,14-PGJ2
SMP0000094	PW_C002100	Delta-12-Prostaglandin J2
SMP0000094	PW_C001847	Oxidized glutathione
SMP0000094	PW_C001986	15(S)-HETE
SMP0000094	PW_C002106	15(S)-HPETE
SMP0000094	PW_C040450	5,6-Epoxytetraene
SMP0000094	PW_C000095	L-Glutamic acid
SMP0000094	PW_C001775	Leukotriene D4
SMP0000094	PW_C000933	Leukotriene C4
SMP0000094	PW_C000080	Glutathione
SMP0000094	PW_C002098	12-Keto-leukotriene B4
SMP0000094	PW_C001005	Zinc (II) ion
SMP0000094	PW_C001030	Leukotriene A4
SMP0000094	PW_C001420	Water
SMP0000094	PW_C000143	NADP
SMP0000094	PW_C001065	Oxygen
SMP0000094	PW_C000146	NADPH
SMP0000094	PW_C000853	Leukotriene B4
SMP0000094	PW_C002644	20-Carboxy-leukotriene B4
SMP0000094	PW_C001162	20-Hydroxy-leukotriene B4
SMP0000094	PW_C001799	Heme
SMP0000094	PW_C009093	Sulindac

蛋白质

SMPDB ID	蛋白质id	蛋白质的名字
SMP0000094	Q08477	Leukotriene-B(4) omega-hydroxylase 2
SMP0000094	P98187	Cytochrome P450 4F8
SMP0000094	P0C869	Cytosolic phospholipase A2 beta
SMP0000094	P18054	Arachidonate 12-lipoxygenase, 12S-type
SMP0000094	Q02928	Cytochrome P450 4A11
SMP0000094	Q7Z449	Cytochrome P450 2U1
SMP0000094	P51589	Cytochrome P450 2J2
SMP0000094	O75342	Arachidonate 12-lipoxygenase, 12R-type
SMP0000094	P05181	Cytochrome P450 2E1
SMP0000094	O15296	Arachidonate 15-lipoxygenase B
SMP0000094	P09917	Arachidonate 5-lipoxygenase
SMP0000094	P34913	Bifunctional epoxide hydrolase 2
SMP0000094	P20813	Cytochrome P450 2B6
SMP0000094	P10632	Cytochrome P450 2C8
SMP0000094	P16050	Arachidonate 15-lipoxygenase
SMP0000094	P16152	Carbonyl reductase [NADPH] 1
SMP0000094	Q8TBF2	Prostamide/prostaglandin F synthase
SMP0000094	O14684	Prostaglandin E synthase
SMP0000094	P24557	Thromboxane-A synthase
SMP0000094	P42330	Aldo-keto reductase family 1 member C3
SMP0000094	P41222	Prostaglandin-H2 D-isomerase
SMP0000094	Q16647	Prostacyclin synthase
SMP0000094	P07203	Glutathione peroxidase 1
SMP0000094	P19440	Gamma-glutamyltranspeptidase 1
SMP0000094	Q16873	Leukotriene C4 synthase
SMP0000094	P09960	Leukotriene A-4 hydrolase
SMP0000094	P78329	Leukotriene-B(4) omega-hydroxylase 1
SMP0000094	P35354	Prostaglandin G/H synthase 2
SMP0000094	P23219	Prostaglandin G/H synthase 1