SMPDB_ID

SMP0000093

PW_ID

PW000135

图片

主题

Drug Action

描述

Diclofenac (also named Voltaren) is a nonsteroidal anti-inflammatory drug (NSAID). It can be used to treat prostaglandin G/H synthase related fever, swelling, pain and inflammation. Diclofenac can block prostaglandin synthesis by the action of inhibition of prostaglandin G/H synthase 1 and 2. Prostaglandin G/H synthase 1 and 2 catalyze the arachidonic acid to prostaglandin G2, and also catalyze prostaglandin G2 to prostaglandin H2 in the metabolism pathway. Decreased prostaglandin synthesis is caused by presence of diclofenac.

代谢物

SMPDB ID	代谢物id	代谢物的名字
SMP0000093	PW_C040708	2,3-Dinor-8iso prostaglandin F2alpha
SMP0000093	PW_C040709	2,3-Dinor-8iso prostaglandin F1alpha
SMP0000093	PW_C006388	LysoPC(14:0/0:0)
SMP0000093	PW_C003933	PC(14:0/20:4(5Z,8Z,11Z,14Z))
SMP0000093	PW_C040452	12(S)-HETE
SMP0000093	PW_C008524	12-KETE
SMP0000093	PW_C040453	12(R)-HETE
SMP0000093	PW_C002105	12(S)-HPETE
SMP0000093	PW_C002614	20-Hydroxyeicosatetraenoic acid
SMP0000093	PW_C002163	8-Isoprostane
SMP0000093	PW_C002171	8-HETE
SMP0000093	PW_C002179	12(R)-HPETE
SMP0000093	PW_C006775	19(S)-HETE
SMP0000093	PW_C002183	8(S)-HPETE
SMP0000093	PW_C001579	5,6-DHET
SMP0000093	PW_C001477	5,6-Epoxy-8,11,14-eicosatrienoic acid
SMP0000093	PW_C001561	8,9-DiHETrE
SMP0000093	PW_C001511	8,9-Epoxyeicosatrienoic acid
SMP0000093	PW_C001814	Prostaglandin G2
SMP0000093	PW_C000353	Calcium
SMP0000093	PW_C006774	5-HPETE
SMP0000093	PW_C001562	11,12-DiHETrE
SMP0000093	PW_C002170	11,12-Epoxyeicosatrienoic acid
SMP0000093	PW_C000423	Magnesium
SMP0000093	PW_C001529	14,15-DiHETrE
SMP0000093	PW_C002113	14,15-Epoxy-5,8,11-eicosatrienoic acid
SMP0000093	PW_C002172	16(R)-HETE
SMP0000093	PW_C002174	11,12,15-THETA
SMP0000093	PW_C002389	15H-11,12-EETA
SMP0000093	PW_C002181	11,14,15-THETA
SMP0000093	PW_C002180	11H-14,15-EETA
SMP0000093	PW_C008133	Fe3+
SMP0000093	PW_C000821	Arachidonic acid
SMP0000093	PW_C002104	11-Dehydro-thromboxane B2
SMP0000093	PW_C002099	Prostaglandin B2
SMP0000093	PW_C001820	Thromboxane B2
SMP0000093	PW_C040451	Prostaglandin-c2
SMP0000093	PW_C001699	Prostaglandin A2
SMP0000093	PW_C000889	Prostaglandin F2a
SMP0000093	PW_C000949	Prostaglandin E2
SMP0000093	PW_C001121	Thromboxane A2
SMP0000093	PW_C006776	11-Epi-PGF2a
SMP0000093	PW_C001068	Prostaglandin H2
SMP0000093	PW_C001084	Prostaglandin D2
SMP0000093	PW_C001028	Prostaglandin I2
SMP0000093	PW_C001687	Prostaglandin J2
SMP0000093	PW_C006229	5-KETE
SMP0000093	PW_C006773	5-HETE
SMP0000093	PW_C002103	6-Ketoprostaglandin E1
SMP0000093	PW_C001726	6-Keto-prostaglandin F1a
SMP0000093	PW_C002398	15-Deoxy-d-12,14-PGJ2
SMP0000093	PW_C002100	Delta-12-Prostaglandin J2
SMP0000093	PW_C001847	Oxidized glutathione
SMP0000093	PW_C001986	15(S)-HETE
SMP0000093	PW_C002106	15(S)-HPETE
SMP0000093	PW_C040450	5,6-Epoxytetraene
SMP0000093	PW_C000095	L-Glutamic acid
SMP0000093	PW_C001775	Leukotriene D4
SMP0000093	PW_C000933	Leukotriene C4
SMP0000093	PW_C000080	Glutathione
SMP0000093	PW_C002098	12-Keto-leukotriene B4
SMP0000093	PW_C001005	Zinc (II) ion
SMP0000093	PW_C001030	Leukotriene A4
SMP0000093	PW_C001420	Water
SMP0000093	PW_C000143	NADP
SMP0000093	PW_C001065	Oxygen
SMP0000093	PW_C000146	NADPH
SMP0000093	PW_C000853	Leukotriene B4
SMP0000093	PW_C002644	20-Carboxy-leukotriene B4
SMP0000093	PW_C001162	20-Hydroxy-leukotriene B4
SMP0000093	PW_C001799	Heme
SMP0000093	PW_C009075	Diclofenac

蛋白质

SMPDB ID	蛋白质id	蛋白质的名字
SMP0000093	Q08477	Leukotriene-B(4) omega-hydroxylase 2
SMP0000093	P98187	Cytochrome P450 4F8
SMP0000093	P0C869	Cytosolic phospholipase A2 beta
SMP0000093	P18054	Arachidonate 12-lipoxygenase, 12S-type
SMP0000093	Q02928	Cytochrome P450 4A11
SMP0000093	Q7Z449	Cytochrome P450 2U1
SMP0000093	P51589	Cytochrome P450 2J2
SMP0000093	O75342	Arachidonate 12-lipoxygenase, 12R-type
SMP0000093	P05181	Cytochrome P450 2E1
SMP0000093	O15296	Arachidonate 15-lipoxygenase B
SMP0000093	P23219	Prostaglandin G/H synthase 1
SMP0000093	P09917	Arachidonate 5-lipoxygenase
SMP0000093	P34913	Bifunctional epoxide hydrolase 2
SMP0000093	P20813	Cytochrome P450 2B6
SMP0000093	P10632	Cytochrome P450 2C8
SMP0000093	P16050	Arachidonate 15-lipoxygenase
SMP0000093	P16152	Carbonyl reductase [NADPH] 1
SMP0000093	Q8TBF2	Prostamide/prostaglandin F synthase
SMP0000093	O14684	Prostaglandin E synthase
SMP0000093	P24557	Thromboxane-A synthase
SMP0000093	P42330	Aldo-keto reductase family 1 member C3
SMP0000093	P41222	Prostaglandin-H2 D-isomerase
SMP0000093	Q16647	Prostacyclin synthase
SMP0000093	P07203	Glutathione peroxidase 1
SMP0000093	P19440	Gamma-glutamyltranspeptidase 1
SMP0000093	Q16873	Leukotriene C4 synthase
SMP0000093	P09960	Leukotriene A-4 hydrolase
SMP0000093	P78329	Leukotriene-B(4) omega-hydroxylase 1
SMP0000093	P35354	Prostaglandin G/H synthase 2