1,2,3,4-Tetrahydro-beta-carboline
IUPAC 名称
1H,2H,3H,4H,9H-pyrido[3,4-b]indole
描述
Tetrahydro-b-carbolines (THbCs)are potential neuroactive alkaloids found in chocolate and cocoa.
The formation of 1,2,3,4-tetrahydro-/3-carbolines (THBCs), via the Pictet-Spengler condensation of tryptamines with formaldehyde, has been demonstrated repeatedly in incubations of various mammalian tissues containing added indolethylamine substrate and the methyl donors .5-methyltetrahydrofolate (5-MTHF) or S-adenosylmethionine(SAM).
It is concluded that the formation of these THBCs is an artifact produced by the enzymatic liberation of formaldehyde from the methyl donors and the subsequent non-enzymatic condensation of this formaldehyde with the indole substrates. The formation of THBCs in vivo has thus remained a point of contention.
(PMID: 7213417) [HMDB]. 1,2,3,4-Tetrahydro-beta-carboline is a biomarker for the consumption of beer.
异构
C1CC2=C(CN1)NC1=C2C=CC=C1
InChI标识符
InChI=1S/C11H12N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-4,12-13H,5-7H2
键
CFTOTSJVQRFXOF-UHFFFAOYSA-N