Fluticasone
IUPAC 名称
(1R,2S,8S,10S,13R,14R,15S,17S)-1,8-difluoro-14-{[(fluoromethyl)sulfanyl]carbonyl}-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl propanoate
描述
Hanburys and Flovent and Flonase by GlaxoSmithKline.; Fluticasone propionate is a potent glucocorticoid often prescribed as treatment for asthma and allergic rhinitis. It is marketed with the brand name Flixotide and Flixonase by Allen & Fluticasone is a potent glucocorticoid often prescribed as treatment for asthma and allergic rhinitis.
corticosteroids are the most effective anti-inflammatory therapy for allergic diseases, and these drugs inhibit T helper cell type 2 (TH2 T-cell) activation, believed to happens through increased suppression by immunoregulatory T cells CD4+CD25+ (PMID 15316506); Fluticasone propionate is a potent glucocorticoid often prescribed as treatment for asthma and allergic rhinitis. It is marketed with the brand name Flixotide and Flixonase by Allen & Hanburys and Flovent and Flonase by GlaxoSmithKline. [HMDB]
异构
[H][C@@]12C[C@H](F)C3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]1(C)C2C[C@@H](C)[C@]1(OC(=O)CC)C(=O)SCF
InChI标识符
InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15?,16+,18+,19+,22+,23+,24+,25+/m1/s1
键
WMWTYOKRWGGJOA-SMFDZHJNSA-N