Pravastatin
IUPAC 名称
(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid
描述
Pravastatin is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease.
Pravastatin was identified originally in a mold called Nocardia autotrophica by researchers of the Sankyo Pharma Inc; An antilipemic fungal metabolite isolated from cultures of Nocardia autotrophica. It acts as a competitive inhibitor of HMG CoA reductase (hydroxymethylglutaryl CoA reductases); In medicine and pharmacology, pravastatin (Pravachol or Selektine) is a member of the drug class of statins, used for lowering cholesterol and preventing cardiovascular disease. [HMDB]
异构
[H][C@@](O)(CC[C@]1([H])C2C(C=C[C@]1([H])C)=C[C@@]([H])(O)C[C@]2([H])OC(=O)[C@@]([H])(C)CC)C[C@@]([H])(O)CC(O)=O
InChI标识符
InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22?/m0/s1
键
TUZYXOIXSAXUGO-HBFVYRAQSA-N