8R-Hydroperoxylinoleic acid
IUPAC 名称
(8R)-8-hydroperoxyoctadeca-9,12-dienoic acid
描述
8(R)-hydroperoxylinoleic acid (8(R)-EPODE) is an oxidized product of linoleic acid. Oxidized lipids such as 8(R)-HPODE can decrease cellular proteoglycan metabolism in endothelial monolayers and alter mRNA levels of major specific proteoglycans in a concentration-dependent manner. This may have implications in lipid-mediated disruption of endothelial barrier function and atherosclerosis. (PMID: 8645361, 9507987) [HMDB]
异构
[H][C@](CCCCCCC(O)=O)(OO)C=CCC=CCCCCC
InChI标识符
InChI=1S/C18H32O4/c1-2-3-4-5-6-7-8-11-14-17(22-21)15-12-9-10-13-16-18(19)20/h6-7,11,14,17,21H,2-5,8-10,12-13,15-16H2,1H3,(H,19,20)/t17-/m0/s1
键
RGJSGXNKRWWCOQ-KRWDZBQOSA-N