Cholestane-3,7,12,25-tetrol
IUPAC 名称
(1S,2S,10R,11S,14R,15R)-14-[(2R)-6-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane-5,9,16-triol
描述
Cholestane-3,7,12,25-tetrol is an intermediate in the bile acid biosynthetic pathways accumulating (together with other 25-hydroxylated bile alcohols intermediates and cholestanol) in Cerebrotendinous xanthomatosis (CTX, a rare recessively inherited lipid storage disease characterized by a markedly reduced production of chenodeoxycholic acid) (PMID 11181760) [HMDB]
异构
[H][C@@]12CC[C@H]([C@H](C)CCCC(C)(C)O)[C@@]1(C)C(O)C[C@@]1([H])[C@@]2([H])C(O)CC2CC(O)CC[C@]12C
InChI标识符
InChI=1S/C27H48O4/c1-16(7-6-11-25(2,3)31)19-8-9-20-24-21(15-23(30)27(19,20)5)26(4)12-10-18(28)13-17(26)14-22(24)29/h16-24,28-31H,6-15H2,1-5H3/t16-,17?,18?,19-,20+,21+,22?,23?,24+,26+,27-/m1/s1
键
NTIXPPFPXLYJCT-OWOWEXKPSA-N