3b,17a-Dihydroxy-5a-androstane
IUPAC 名称
(2S,5S,14R,15S)-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecane-5,14-diol
描述
3b,17a-Dihydroxy-5a-androstane is an steroid found in the monosulfate fraction of normal human feces. Several steroids identified in the disulfate fraction of human bile are found in the monosulfate fraction of human feces, indicating partial hydrolysis of diconjugates in the intestine. The androstanediols and pregnanediols found in the feces are primarily of a 3b-hydroxy-5a- or 3b-hydroxy-5b-structure, whereas those in the bile are of a 3a-hydroxy-5a- or 3a-hydroxy-5b-structure. This suggests conversion of a 3a-hydroxyl to a 3b-hydroxyl in the intestine in vivo. 3b,17a-Dihydroxy-5a-androstane is also found unconjugated in normal human plasma. (PMID 4245755, 4223807, 4321841, 1769135) [HMDB]
异构
C[C@]12CCC3C(CCC4C[C@@H](O)CC[C@]34C)C1CC[C@H]2O
InChI标识符
InChI=1S/C19H32O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-17,20-21H,3-11H2,1-2H3/t12?,13-,14?,15?,16?,17+,18-,19-/m0/s1
键
CBMYJHIOYJEBSB-ILNNWSBUSA-N