6,8-Purinediol
IUPAC 名称
pentakis(9H-purine-6,8-diol)
描述
Component of hen egg yolk
6,8-Dihydroxypurine is an endogenous nucleoside found in human fluids. Purine bases are present in higher amounts in tumor-bearing patients compared to healthy controls. DNA hypermethylation is a common finding in malignant cells and has been explored as a therapeutic target for hypomethylating agents. When chemical bonds to DNA, the DNA becomes damaged and proper and complete replication cannot occur to make the normal intended cell. A DNA adduct is an abnormal piece of DNA covalently-bonded to a cancer-causing chemical. This has shown to be the start of a cancerous cell, or carcinogenesis. DNA adducts in scientific experiments are used as bio-markers and as such are themselves measured to reflect quantitatively, for comparison, the amount of cancer in the subject. (PMID: 3506820, 17044778, 17264127, 16799933) [HMDB]
异构
OC1=NC2=C(N1)NC=NC2=O.OC1=NC2=C(N1)N=CN=C2O.OC1=NC2=C(O)N=CNC2=N1.O=C1NC2=C(N1)C(=O)N=CN2.O=C1NC2=C(N1)C(=O)NC=N2
InChI标识符
InChI=1S/5C5H4N4O2/c5*10-4-2-3(6-1-7-4)9-5(11)8-2/h5*1H,(H3,6,7,8,9,10,11)
键
ZHWYDMYXJSUNAJ-UHFFFAOYSA-N