N2-gamma-L-Glutamyl-L-arginine
IUPAC 名称
2-amino-4-[(4-carbamimidamido-1-carboxybutyl)carbamoyl]butanoic acid
描述
Constituent of Allium cepa (onion), Panax ginseng (ginseng)
After intravenous administration of DTIC-Dome, the volume of distribution exceeds total body water content suggesting localization in some body tissue, probably the liver. Its disappearance from the plasma is biphasic with initial half-life of 19 minutes and a terminal half-life of 5 hours. 1 In a patient with renal and hepatic dysfunctions, the half-lives were lengthened to 55 minutes and 7.2 hours. 1 The average cumulative excretion of unchanged DTIC in the urine is 40% of the injected dose in 6 hours. 1 DTIC is subject to renal tubular secretion rather than glomerular filtration. At therapeutic concentrations DTIC is not appreciably bound to human plasma protein. N2-gamma-L-Glutamyl-L-arginine is found in garden onion, tea, and onion-family vegetables.
异构
NC(CCC(=O)NC(CCCNC(N)=N)C(O)=O)C(O)=O
InChI标识符
InChI=1S/C11H21N5O5/c12-6(9(18)19)3-4-8(17)16-7(10(20)21)2-1-5-15-11(13)14/h6-7H,1-5,12H2,(H,16,17)(H,18,19)(H,20,21)(H4,13,14,15)
键
AKAHWGGIUSJNNM-UHFFFAOYSA-N