n-Nitrosodi-n-propylamine
描述
N-Nitrosodi-n-propylamine is a chemical produced by industry in small amounts for research. Small amounts of n-nitrosodi-n-propylamine are also produced as a side reaction during some manufacturing processes, as a contaminant in some weed killers, and during the manufacture of some rubber products. It is one ingredient of cigarette. (L216)
类别
"Cigarette Toxin", "Industrial/Workplace Toxin", "Pollutant", "Synthetic Toxin"
同义词
"2-Oxo-1,1-dipropylhydrazine", "Di-N-propylnitrosamine", "Di-N-propylnitrosoamine", "Dipropylnitrosamine", "N,N-di-N-propylnitrosamine", "N,N-dipropylnitrosamine", "N-nitroso di-N-propylamine", "N-nitroso(di-N-propyl)amine", "N-nitroso-N-dipropylamine", "N-Nitroso-N-propyl-1-propanamine", "N-nitroso-N-propylpropan-1-amine", "N-Nitrosodi-N-propylamine", "N-nitrosodi-N-propylamine", "N-nitrosodipropylamine", "Nitrosodipropylamine", "Nitrous dipropylamide"
IUPAC 名称
nitrosodipropylamine
传统名称
N-nitrosodipropylamine
InChI 标识符
InChI=1S/C6H14N2O/c1-3-5-8(7-9)6-4-2/h3-6H2,1-2H3
键
InChIKey=YLKFDHTUAUWZPQ-UHFFFAOYSA-N
大分类
Organic nitrogen compounds
类型
Organonitrogen compounds
子类
Organic nitroso compounds
直接大类
Organic N-nitroso compounds
另外分类
"Hydrocarbon derivatives", "Organic oxides", "Organopnictogen compounds"
取代基
"Aliphatic acyclic compound", "Hydrocarbon derivative", "Organic n-nitroso compound", "Organic oxide", "Organic oxygen compound", "Organopnictogen compound"
分子框架
Aliphatic acyclic compounds
地位
Detected and Not Quantified
蜂窝位置
"Cytoplasm", "Extracellular"
熔点/沸点/溶解度
/206 °C/13 mg/mL at 24 °C [MIRVISH,SS et al.(1976)]
暴露途径
Oral (L216); inhalation (L216) ; dermal (L216).
毒性机制
Reactive metabolites of n-nitrosodi-n-propylamine are believed to form adducts with DNA, resulting in carcinogenic effects. (L216)
代谢
n-Nitrosodi-n-propylamine can be absorbed through oral, inhalation, or dermal routes. It is metabolized by cytochrome p-450 enzymes (mainly CYP 2E1) into its reactive metabolites via oxidation at the alpha, beta and gamma carbon positions. Alpha carbon oxidation is regarded as the primary pathway, resulting in formation of propionaldehyde, 1-propanol, and 2-propanol. The metabolites of n-nitrosodi-n-propylamine are excreted mainly in the urine. (L216, A152)
毒性值
LD50: 480 mg/kg (Oral, Rat) (T35)
LD50: 487 mg/kg (Subcutaneous, Rat) (T35)
致癌性
2B, possibly carcinogenic to humans. (L135)
用途/来源
Small amounts of n-nitrosodi-n-propylamine are also produced as a side reaction during some manufacturing processes, as a contaminant in some weed killers, and during the manufacture of some rubber products. (L216)
最低风险等级
Acute Oral: 0.095 mg/kg/day (L134)
健康影响
High levels of n-nitrosodi-n-propylamine may damage the liver, lung, stomach, kidneys, and heart. n-Nitrosodi-n-propylamine is also a likely carcinogen. (L216)
创建于
2009-03-06 18:58:06 UTC
更新于
2014-12-24 20:21:08 UTC