Radium-226
SmallMolecule
T3DB_ID
T3D0100
描述
Radium is a radioactive chemical element which has the symbol Ra and atomic number 88. Its appearance is almost pure white, but it readily oxidizes on exposure to air, turning black. Radium is an alkaline earth metal that is formed when uranium and thorium break down in the environment. It is extremely radioactive. Radium-226 is the most stable isotope, has a half-life of 1602 years, and decays into radon gas. Radium has been used as a radiation source for treating cancer, in radiography of metals, and combined with other metals as a neutron source for research and radiation instrument calibration. Until the 1960s, radium was a component of the luminous paints used for watch and clock dials, instrument panels in airplanes, military instruments, and compasses. (L991, L1835)
类别
"Industrial/Workplace Toxin", "Pollutant", "Airborne Pollutant", "Natural Toxin"
同义词
"226Ra", "88Ra", "Radium", "Radium 226", "Radium, isotope of mass 226"
CAS登记号
13982-63-3
化学式
Ra
平均分子量
226.0254
单同位素质量
226.025402555
IUPAC 名称
(²²⁶Ra)radium
传统名称
(²²⁶Ra)radium
简化分子线性输入规范
[226Ra]
InChI 标识符
InChI=1S/Ra/i1+0
InChIKey=HCWPIIXVSYCSAN-IGMARMGPSA-N
化合物类型
大分类
类型
子类
直接大类
另外分类
取代基
分子框架
外部描述符
地位
Detected and Not Quantified
起源
Exogenous
蜂窝位置
"Cytoplasm", "Extracellular"
生物流体位置
组织位置
途径
状态
Solid
外貌
Its appearance is almost pure white, but it readily oxidizes on exposure to air, turning black. (L991)
熔点/沸点/溶解度
973°K (700°C , 1292°F )/1737 °C/
日志P
暴露途径
Inhalation (L991) ; injection (L991) ; oral (L991) ; dermal (L991)
毒性机制
Ionizing radiation produced by radium damages the DNA, resulting in gene mutations and chromosomal aberrations. This can both initiate and promote carcinogenesis, and interfere with reproduction and development. Since radium`s similarity to calcium allows it to deposit in the bones, bone cancer is of particular risk. (L1835)
代谢
Due to its radioactivity, radium can affect the body following ingestion, inhalation, or dermal exposure. If inhalated, it may accumulate in the lungs. Once in the body radium may deposit in the bones, mainly on the surface and areas where new bone is being formed. Radium is not metabolized and is excreted primarily in the faeces. (L1835)
毒性值
致死剂量
致癌性
1, carcinogenic to humans. (L135)
用途/来源
Radium has been used as a radiation source for treating cancer, in radiography of metals, and combined with other metals as a neutron source for research and radiation instrument calibration. Until the 1960s, radium was a component of the luminous paints used for watch and clock dials, instrument panels in airplanes, military instruments, and compasses. (L1835)
最低风险等级
健康影响
Radium is highly radioactive and its decay product, radon gas, is also radioactive. It has been shown to cause effects on the blood (anemia) and eyes (cataracts). Inhalation, injection, ingestion or body exposure to radium can cause cancer and other disorders, due to its radioactivity. Since radium is chemically similar to calcium, it has the potential to cause great harm by replacing it in bones, and bone cancer is of particular risk. (L991, L1835)
症状
Exposure to high doses of ionizing radiation results in acute radiation syndrome, which can cause skin burns, hair loss, nausea, vomiting, dizziness, disorientation, low blood pressure, headache, fatigue, weakness, fever, birth defects, illness, infection, and death. (L1837, L1852)
治疗
Treatment reversing the effects of irradiation is currently not possible. Anaesthetics and antiemetics are administered to counter the symptoms of exposure, as well as antibiotics for countering secondary infections due to the resulting immune system deficiency. (L1852)
药库 ID
HMDB_ID
PubChem 化合物 ID
6328144
维基百科链接
http://en.wikipedia.org/wiki/Radium
创建于
2009-03-06 18:58:05 UTC
更新于
2014-12-24 20:21:06 UTC
目标
毒素T3DB ID毒素名称目标名称
T3D0100 Radium-226 DNA
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