Cyclotrimethylenetrinitramine
描述
Cyclotrimethylenetrinitramine is a chemical compound also called RDX, which stands for Royal Demolition Explosive. It is also known as cyclonite or hexogen. The chemical name for RDX is 1,3,5-trinitro-1,3,5-triazine and it is a very explosive white powder that creates fumes when it is burned with other substances. As such, it is used as an explosive and it is also used in combination with other ingredients in explosives. RDX is a synthetic product that does not occur naturally in the environment. (L259)
类别
"Industrial/Workplace Toxin", "Synthetic Toxin"
同义词
"1,3, 5-Trinitrohexahydro-1,3,5-triazine", "1,3,5-Triaza-1,3,5-trinitrocyclohexane", "1,3,5-Trinitro-1,3, 5-triazacyclohexane", "1,3,5-Trinitro-1,3,5-triazacyclohexane", "1,3,5-Trinitro-1,3,5-triazinane", "1,3,5-Trinitrohexahydro-1,3,5-triazine", "1,3,5-trinitrohexahydro-p-triazine", "1,3,5-Trinitrohexahydro-s-triazine", "1,3,5-Trinitroperhydro-1,3, 5-triazine", "1,3,5-Trinitroperhydro-1,3,5-triazine", "Cyclonit", "Cyclonite", "Cyclonite (cyclotrimethylene trinitramine)", "Cyclotrimethylenenitramine", "Geksogen", "Hexahydro-1,3 ,5-trinitro-1,3 5-triazine", "Hexahydro-1,3, 5-trinitro-1,3,5-triazine", "Hexahydro-1,3,5-trinitro-1,3,5-triazine", "Hexahydro-1,3,5-trinitro-s-triazine", "Hexogen", "Hexolite", "Perhydro-1,3,5-trinitro-1,3,5-triazine", "RDX", "SYM-trimethylene trinitramine", "SYM-trimethylenetrinitramine", "Trinitrocyclotrimethylene triamine", "Trinitrohexahydrotriazine", "Trinitrotrimethylenetriamine"
IUPAC 名称
1,3,5-trinitro-1,3,5-triazinane
传统名称
cyclotrimethylenetrinitramine
简化分子线性输入规范
[O-][N+](=O)N1CN(CN(C1)[N+]([O-])=O)[N+]([O-])=O
InChI 标识符
InChI=1S/C3H6N6O6/c10-7(11)4-1-5(8(12)13)3-6(2-4)9(14)15/h1-3H2
键
InChIKey=XTFIVUDBNACUBN-UHFFFAOYSA-N
大分类
Organoheterocyclic compounds
另外分类
"Azacyclic compounds", "Hydrocarbon derivatives", "Organic nitro compounds", "Organic oxides", "Organonitrogen compounds", "Organopnictogen compounds"
取代基
"1,3,5-triazinane", "Aliphatic heteromonocyclic compound", "Allyl-type 1,3-dipolar organic compound", "Azacycle", "Hydrocarbon derivative", "Organic 1,3-dipolar compound", "Organic nitro compound", "Organic nitrogen compound", "Organic oxide", "Organic oxygen compound", "Organonitrogen compound", "Organopnictogen compound"
分子框架
Aliphatic heteromonocyclic compounds
外部描述符
"1,3,5-triazinanes", "N-nitro compound"
地位
Detected and Not Quantified
蜂窝位置
"Cytoplasm", "Extracellular"
熔点/沸点/溶解度
205.5°C//0.0597 mg/mL at 25 °C [YALKOWSKY,SH & HE,Y (2003)]
暴露途径
Oral (L259); inhalation (L259) ; dermal (L259)
毒性机制
RDX can get into the lungs after breathing in the fumes of burning RDX or breathing in the dust from powdered RDX. It can also enter the body after ingestion of contaminated water. It may also pass through the skin into the bloodstream or enter through cuts or breaks in the skin. It also blocks electron transport. (T10, L259)
代谢
There are no studies available regarding RDX metabolites in humans following inhalation, oral, or dermal exposure. Some studies reported that 4-nitro-2,4-diazabutanal, and nitrite ions are produced through biotransformation of RDX by cytochrome P450. The limited toxicological data show that RDX is absorbed through the gastrointestinal system, lungs, and skin, and is distributed to the cerebrospinal fluid, plasma, urine, and feces. RDX will leaves the body in the breath and urine within a few days. (L259,A162)
致癌性
No indication of carcinogenicity to humans (not listed by IARC).
用途/来源
RDX is used as an explosive and is also used in combination with other ingredients in explosives. Exposure may occur by breathing dust containing RDX, contact with the skin, or drinking contaminated water. (L259)
最低风险等级
Acute Oral: 0.06 mg/kg/day (Rat) (L259)
Intermediate Oral: 0.03 mg/kg/day (Rat) (L259)
健康影响
RDX can cause seizures. Inhalation exposure to RDX can lead to gastrointestinal, hematological, hepatic, and renal effects. (L259)
症状
Symptoms of RDX exposure include epileptiform seizures, insomnia, restlessness, headache, dizziness, nausea, vomiting and irritability. Temporary postconvulsive amnesia, malaise, fatigue, and asthenia can follow the seizures. (T29)
治疗
Following oral exposure, symptomatic patients should be given adequate respiratory support during seizures. Monitor liver and renal function tests and urinalysis in patients with significant exposure. Following inhalation exposure, move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids. Following eye exposure, irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility. Following dermal exposure, remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists. (T36)
创建于
2009-03-06 18:58:04 UTC
更新于
2014-12-24 20:21:05 UTC