同义词
"1,1'-Oxybis(2-chloro)ethane", "1,1'-Oxybis(2-chloroethane)", "1,5-Dichloro-3-oxapentane", "1-Chloro-2-(.beta.-chloroethoxy)ethane", "1-Chloro-2-(2-chloroethoxy)ethane", "1-Chloro-2-(b-chloroethoxy)ethane", "1-Chloro-2-(beta-chloroethoxy)ethane", "2, 2'-Dichlorodiethyl ether", "2,2'-Dichlorethyl ether", "2,2'-Dichlorodiethyl ether", "2,2'-Dichlorodiethyl oxide", "2,2'-dichlorodiethylether", "2,2'-Dichloroethyl ether", "2-Chloroethyl ether", "b,b'-dichlorodiethyl ether", "b,b'-dichloroethyl ether", "b,b-dichlorodiethyl ether", "Beta ,beta'-dichlorodiethyl ether", "Beta,beta'-dichlorodiethyl ether", "Beta,beta-dichlorodiethyl ether", "Beta,beta-dichloroethyl ether", "Beta-chloroethyl ether", "Bis(.beta.-chloroethyl) ether", "Bis(2-chloroethyl)ether", "Bis(b-chloroethyl) ether", "Bis(beta-chloroethyl) ether", "Bis(chloro-2-ethyl) oxide", "Bis(chloroethyl) ether", "Bis(chloroethyl)ether", "Bis(chloroethyl)ether (bcee)", "Bis-2-chloroethylether", "Chlorex", "Chloroethyl ether", "Clorex", "Di(.beta.-chloroethyl) ether", "Di(2-chloroethyl) ether", "Di(b-chloroethyl) ether", "Di(beta-chloroethyl)ether", "Di(chloroethyl) oxide", "Dichlorodiethyl ether", "Dichloroether", "Dichloroethyl ether", "Dichloroethyl oxide", "Dicholoroethyl ether", "Diethylene glycol dichloride", "Oxybis(2-chloroethane)", "S-dichloroethyl ether", "SYM-dichloroethyl ether"
代谢
BCEE is absorbed following inhalation exposure, oral administration, as well as contact to the skin. BCEE is distributed through the body, but highest levels are found in the liver, kidney and small intestine, while much lower levels are found in lung, spleen and muscle. BCEE is extensively metabolized to thiodiglycolic acid (TDGA), 2-chloroethoxyacetic acid (CEAA), and N-acetyl-S-[2-(2-chloroethoxy)ethyl]-L-cysteine, with TDGA being the principal endproduct. Smaller amounts of BCEE are metabolized by oxidation or substitution at a chlorine without ether cleavage. Approximately 80% of BCEE administered orally is excreted as TDGA within 48 hours. Smaller amounts are excreted in feces or expired air and only a very small fraction of the dose remains in the body. This indicates that BCEE is effectively excreted, and that it has a low tendency to accumulate in tissues. (L183, A129)
用途/来源
Bis(2-chloroethyl) ether is used in pesticides. It is also used as a solvent, cleaner, component of paint and varnish, rust inhibitor, or as a chemical intermediate to make other chemicals. Exposure occurs from consumption of drinking water that contains BCEE, breathing BCEE vapors, and dermal contact. (L183)
症状
Symptoms of BCEE exposure include coughing, sore throat, nausea, vomiting, burning sensation, redness of the exposed surface, laboured breathing, and abdominal pain, depending on the route of exposure. Symptoms may be delayed. (L184)