1,1-Dichloroethene
描述
1,1-Dichloroethene is a manufactured organochloride compound. It is used in the production of certain plastics as a comonomer in the polymerization of vinyl chloride, acrylonitrile, and acrylates. It is also used to make flame retardant coatings for fiber and carpet backings, and in piping, coating for steel pipes, and in adhesive applications. (L185, L186)
类别
"Industrial/Workplace Toxin", "Pollutant", "Airborne Pollutant", "Synthetic Toxin"
同义词
"1,1-DCE", "1,1-Dichloroethene monomer", "1,1-Dichloroethylene", "Monovinylidene chloride", "Sconatex", "Vinylidene chloride", "Vinylidene chloride (II)", "Vinylidene chloride(II)", "Vinylidene chloride, inhibited", "Vinylidene chloride, monomer", "Vinylidene dichloride", "Vinylidine chloride"
IUPAC 名称
1,1-dichloroethene
InChI 标识符
InChI=1S/C2H2Cl2/c1-2(3)4/h1H2
键
InChIKey=LGXVIGDEPROXKC-UHFFFAOYSA-N
大分类
Organic oxygen compounds
类型
Organooxygen compounds
另外分类
"Chloroalkenes", "Hydrocarbon derivatives", "Organochlorides", "Vinyl chlorides"
取代基
"Aliphatic acyclic compound", "Chloroalkene", "Haloalkene", "Hydrocarbon derivative", "Ketene acetal or derivatives", "Organochloride", "Organohalogen compound", "Vinyl chloride", "Vinyl halide"
分子框架
Aliphatic acyclic compounds
外部描述符
"a small molecule", "chloroethenes"
地位
Detected and Not Quantified
蜂窝位置
"Cytoplasm", "Extracellular"
熔点/沸点/溶解度
-122.5°C/32°C/2.42 mg/mL at 25 °C [HORVATH,AL et al. (1999)]
暴露途径
Oral (L16) ; inhalation (L16) ; dermal (L16)
毒性机制
1,1-Dichloroethene toxicity is caused by its reactive metabolites, which include epoxides, acyl chlorides, and halogenated aldehydes generated via oxidation by cytochrome P-450 2E1. These metabolites, especially 2,2-dichloroacetaldehyde and 2-chloroacetyl chloride, damage the liver by binding to cellular macromolecules. They also form glutathione S conjugates by the action of glutathione S-transferases located in the hepatic cytosol and microsomes. These are delivered to the kidney, where renal processing by beta-lyase and cysteine conjugate S-oxidase lead to nephrotoxic products. The metabolites are also known to damage the bronchiolar Clara cells in the lung. (L185)
代谢
1,1-Dichloroethene is absorbed via oral, inhalation, and dermal routes. It is rapidly distributed in the body, mainly to the liver and kidneys. Hepatic microsomal cytochrome P-450 enzymes metabolize 1,1-dichloroethene into its toxic metabolites, which include epoxides, acyl chlorides, and halogenated aldehydes. The main metabolites are believed to be 2,2-dichloroacetaldehyde and 2-chloroacetyl chloride. These are later detoxified by hydroxylation and conjugation with glutathione. Excretion of 1,1-dichloroethene metabolites occurs primarily in the urine and exhaled air. (L185)
毒性值
LD50: 200 mg/kg (Oral, Rat) (T14)
LC50: 6350 ppm/4 hr (Inhalation, Rat) (T14)
致癌性
3, not classifiable as to its carcinogenicity to humans. (L135)
用途/来源
1,1-Dichloroethene is used in the production of certain plastics as a comonomer in the polymerization of vinyl chloride, acrylonitrile, and acrylates. It is also used to make flame retardant coatings for fiber and carpet backings, and in piping, coating for steel pipes, and in adhesive applications. (L185, T14)
最低风险等级
Intermediate Inhalation: 0.02 ppm (L134)
Chronic Oral: 0.009 mg/kg/day (L134)
健康影响
1,1-Dichloroethene mainly affects the central nervous system. It may lead to sedation, inebriation, convulsions, spasms, and unconsciousness. 1,1-Dichloroethene may also damage the livers, kidneys, and lungs. (L185, L186)
症状
1,1-Dichloroethene mainly affects the central nervous system and may lead to sedation, inebriation, convulsions, spasms, and unconsciousness. It also irritates the respiratory tract, eyes, and skin upon contact. (L185)
治疗
Treatment of 1,1-dichloroethene poisoning is mainly symptomatic. It may include respiratory assistance, gastric lavage, and/or the oral administration of activated charcoal. (L187)
创建于
2009-03-06 18:58:02 UTC
更新于
2014-12-24 20:21:03 UTC
目标
| 毒素T3DB ID | 毒素名称 | 目标名称 |
|---|
| T3D0079 |
1,1-Dichloroethene |
Estrogen receptor beta |
| T3D0079 |
1,1-Dichloroethene |
Estrogen receptor alpha |
| T3D0079 |
1,1-Dichloroethene |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 |
| T3D0079 |
1,1-Dichloroethene |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
| T3D0079 |
1,1-Dichloroethene |
Plasma membrane calcium-transporting ATPase 4 |
| T3D0079 |
1,1-Dichloroethene |
Plasma membrane calcium-transporting ATPase 3 |
| T3D0079 |
1,1-Dichloroethene |
Plasma membrane calcium-transporting ATPase 2 |
| T3D0079 |
1,1-Dichloroethene |
Plasma membrane calcium-transporting ATPase 1 |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit theta |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit rho-3 |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit rho-2 |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit rho-1 |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit pi |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit gamma-3 |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit gamma-2 |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit gamma-1 |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit epsilon |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit delta |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit beta-3 |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit beta-2 |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit beta-1 |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit alpha-6 |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit alpha-5 |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit alpha-4 |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit alpha-3 |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit alpha-2 |
| T3D0079 |
1,1-Dichloroethene |
Gamma-aminobutyric acid receptor subunit alpha-1 |
| T3D0079 |
1,1-Dichloroethene |
Calcium-transporting ATPase type 2C member 2 |
| T3D0079 |
1,1-Dichloroethene |
Calcium-transporting ATPase type 2C member 1 |
| T3D0079 |
1,1-Dichloroethene |
Sodium/potassium-transporting ATPase subunit beta-3 |
| T3D0079 |
1,1-Dichloroethene |
Sodium/potassium-transporting ATPase subunit beta-2 |
| T3D0079 |
1,1-Dichloroethene |
Sodium/potassium-transporting ATPase subunit beta-1 |
| T3D0079 |
1,1-Dichloroethene |
Sodium/potassium-transporting ATPase subunit alpha-4 |
| T3D0079 |
1,1-Dichloroethene |
Sodium/potassium-transporting ATPase subunit alpha-3 |
| T3D0079 |
1,1-Dichloroethene |
Sodium/potassium-transporting ATPase subunit alpha-2 |
| T3D0079 |
1,1-Dichloroethene |
Sodium/potassium-transporting ATPase subunit alpha-1 |
| T3D0079 |
1,1-Dichloroethene |
Sodium/potassium-transporting ATPase subunit gamma |
| T3D0079 |
1,1-Dichloroethene |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 |
| T3D0079 |
1,1-Dichloroethene |
Transient receptor potential cation channel subfamily A member 1 |