beta Endosulfan
描述
Endosulfan, beta is one of two stereoisomers of endosulfan. Endosulfan is an organochlorine insecticide and acaricide. It is used to control insects on food and non-food crops and as a wood preservative. Due to its toxicity and tendency to bioaccumulate, the use of endosulfan is banned in many areas. (L113)
类别
"Pesticide", "Pollutant", "Food Toxin", "Synthetic Toxin"
同义词
"Alpha-thionex", "b Endosulfan", "b-endosulfan", "B-endosulfan-beta", "b-thiodan", "Beta-benzoepin", "Beta-endosulfan", "Beta-thiodan", "Endosulfan 2", "Endosulfan b", "Endosulfan, beta", "Endosulfan-b", "β Endosulfan"
IUPAC 名称
(1R,9S)-1,9,10,11,12,12-hexachloro-4,6-dioxa-5λ⁴-thiatricyclo[7.2.1.0²,⁸]dodec-10-en-5-one
传统名称
(1R,9S)-1,9,10,11,12,12-hexachloro-4,6-dioxa-5λ⁴-thiatricyclo[7.2.1.0²,⁸]dodec-10-en-5-one
简化分子线性输入规范
ClC1=C(Cl)[C@]2(Cl)C3COS(=O)OCC3[C@@]1(Cl)C2(Cl)Cl
InChI 标识符
InChI=1/C9H6Cl6O3S/c10-5-6(11)8(13)4-2-18-19(16)17-1-3(4)7(5,12)9(8,14)15/h3-4H,1-2H2/t3?,4?,7-,8+,19?
键
InChIKey=RDYMFSUJUZBWLH-QTSFFCDANA-N
大分类
Organic oxygen compounds
类型
Organic oxoanionic compounds
另外分类
"Alkyl chlorides", "Chloroalkenes", "Hydrocarbon derivatives", "Organic oxides", "Organochlorides", "Organooxygen compounds", "Oxacyclic compounds", "Vinyl chlorides"
取代基
"Aliphatic heteropolycyclic compound", "Alkyl chloride", "Alkyl halide", "Chloroalkene", "Haloalkene", "Hydrocarbon derivative", "Organic oxide", "Organochloride", "Organohalogen compound", "Organoheterocyclic compound", "Organooxygen compound", "Oxacycle", "Sulfite ester", "Vinyl chloride", "Vinyl halide"
分子框架
Aliphatic heteropolycyclic compounds
地位
Detected and Not Quantified
蜂窝位置
"Actin Cytoskeleton", "Cell junction", "Cytoskeleton", "Cytosol", "Endoplasmic reticulum", "Extracellular", "Lysosome", "Membrane", "Membrane Fraction", "Microsome", "Mitochondrial Matrix", "Nucleolus", "Peroxisome", "Plasma Membrane", "Ribosome", "Sarcoplasmic Reticulum", "Secretory vesicle"
途径
"Apoptosis", "Proteasome", "Oxidative phosphorylation", "Ovarian Steroidogenesis", "Cell cycle", "Antiviral Agents"
外貌
Cream- to brown-colored solid.
熔点/沸点/溶解度
106°C//0.00045 mg/mL at 20 °C [BOWMAN,BT & SANS,WW (1983)]; 0.000325 mg/mL at 22 °C [TOMLIN,C (1994)]
暴露途径
Oral (L114) ; inhalation (L114) ; dermal (L114)
毒性机制
Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. Endosulfan also inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. Endosulfan is also an endocrine disruptor and acts as an agonist at the progesterone receptor and estrogen receptors. (T10, L113, L114, A61, A114)
代谢
Endosulfan is absorbed by inhalation, oral, and dermal routes of exposure. It accumulates mainly in the liver, kidney, and brain, and is metabolized to polar and nonpolar metabolites by cytochrome P-450 enzymes. Endosulfan and its metabolites, which include sulfate, diol, α-hydroxyether, lactone, and ether derivatives of endosulfan, are excreted in the urine and faeces. (L114)
毒性值
LD50: 18 mg/kg (Oral, Rat) (T14)
LD50: 34 mg/kg (Dermal, Rat) (T14)
LD50: 8 mg/kg (Intraperitoneal, Rat) (T14)
LD50: 360 mg/kg (Subcutaneous, Rabbit) (T14)
LC50: 80 mg/m3 over 4 hours (Inhalation, Rat) (T14)
致死剂量
50 to 500 mg/kg for an adult human. (T27)
致癌性
No indication of carcinogenicity to humans (not listed by IARC).
用途/来源
Endosulfan is used as an insecticide, acaricide, and in wood preservatives. (L114)
最低风险等级
Intermediate Oral: 0.005 mg/kg/day (L134)
Chronic Oral: 0.002 mg/kg/day (L134)
健康影响
Endosulfan is a neurotoxin and damages the central nervous system, causing effects such as intermittent muscle twitching and myoclonic jerking. Endosulfan can also damage the kidneys, testes, and liver, and may possibly affect the body's ability to fight infection. It is also an endocrine disruptor and causes reproductive and developmental damage. (T10, L113, L114)
症状
Symptoms of endosulfan poisoning include hyperactivity, hyperreflexia, tremors, dizziness, headache, convulsions, lack of coordination, staggering, difficulty breathing, nausea and vomiting, diarrhea, and in severe cases, unconsciousness. (T10, L113, L114)
治疗
Treatment is symptomatic, aimed at controlling convulsions, coma, and respiratory depression. If ingested, gastric lavage may be performed, followed by administering activated charcoal powder. (L161)
创建于
2009-03-06 18:58:01 UTC
更新于
2014-12-24 20:21:01 UTC