Endrin ketone
SmallMolecule
T3DB_ID
T3D0063
描述
Endrin ketone is the chemical produced when endrin is exposed to light. Endrin is a chlorinated hydrocarbon used as an insecticide on cotton, maize, and rice. It also acts as an avicide and rodenticide. Due to its toxicity and tendency to bioaccumulate, its use is now banned in most parts of the world. (L111)
类别
"Pesticide", "Synthetic Toxin"
同义词
"delta-Keto 153", "delta-Ketoendrin"
CAS登记号
53494-70-5
化学式
C12H8Cl6O
平均分子量
380.909
单同位素质量
377.87063112
IUPAC 名称
1,2,2,3,10,11-hexachloropentacyclo[5.4.1.0³,¹⁰.0⁴,¹².0⁵,⁹]dodecan-8-one
传统名称
endrin ketone
简化分子线性输入规范
ClC1C2(Cl)C3C4CC5C3C(Cl)(C2(Cl)Cl)C1(Cl)C5C4=O
InChI 标识符
InChI=1S/C12H8Cl6O/c13-8-9(14)6-2-1-3(7(6)19)4-5(2)11(9,16)12(17,18)10(4,8)15/h2-6,8H,1H2
InChIKey=IZHZFAQWVKBTSL-UHFFFAOYSA-N
化合物类型
Organic compounds
大分类
Lipids and lipid-like molecules
类型
Prenol lipids
子类
Monoterpenoids
直接大类
Monoterpenoids
另外分类
"Alkyl chlorides", "Hydrocarbon derivatives", "Ketones", "Organic oxides", "Organochlorides"
取代基
"Aliphatic homopolycyclic compound", "Alkyl chloride", "Alkyl halide", "Carbonyl group", "Hydrocarbon derivative", "Ketone", "Monoterpenoid", "Norbornane monoterpenoid", "Organic oxide", "Organic oxygen compound", "Organochloride", "Organohalogen compound", "Organooxygen compound"
分子框架
Aliphatic homopolycyclic compounds
外部描述符
""
地位
Detected and Not Quantified
起源
Exogenous
蜂窝位置
"Membrane"
生物流体位置
组织位置
途径
状态
Solid
外貌
White powder.
熔点/沸点/溶解度
//
日志P
暴露途径
Oral (L111)
毒性机制
Endrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions and causing hyperexcitability of the central nervous system. Endrin also inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the central nervous system. Endrin also causes increased lipid peroxidation, decreased membrane fluidity, and DNA damage in hepatocytes, but the exact mechanism is unknown. (T10, L112)
代谢
Endrin is absorbed orally and distributed primarily to the fat and skin. The major biotransformation product is anti-l 2-hydroxyendrin and the corresponding sulfate, as well as glucuronide metabolites. Anti- and syn-12-hydroxyendrin and 12-ketoendrin are the main toxic metabolites of endrin. Endrin and its metabolites are excreted in urine and feces. (L112)
毒性值
致死剂量
致癌性
No indication of carcinogenicity to humans (not listed by IARC).
用途/来源
Endrin is used as a pesticide. (L111)
最低风险等级
健康影响
Endrin poisoning affects primarily the nerve system. Exposure causes various harmful effects including hyperexcitability, severe central nervous system damage, and death. Endrin is also believed to cause birth defects. (T10, L112)
症状
Symptoms that may result from endrin poisoning are headaches, dizziness, nervousness, confusion, nausea, vomiting, and convulsions. (L112)
治疗
Treatment is symptomatic, aimed at controlling convulsions, coma, and respiratory depression. If ingested, gastric lavage may be performed, followed by administering activated charcoal powder. (L150)
药库 ID
HMDB_ID
PubChem 化合物 ID
62060
维基百科链接
创建于
2009-03-06 18:58:00 UTC
更新于
2014-12-24 20:21:01 UTC
目标
毒素T3DB ID毒素名称目标名称
T3D0063 Endrin ketone Estrogen receptor beta
T3D0063 Endrin ketone Estrogen receptor alpha
T3D0063 Endrin ketone Sodium/potassium-transporting ATPase subunit beta-3
T3D0063 Endrin ketone Sodium/potassium-transporting ATPase subunit beta-2
T3D0063 Endrin ketone Sodium/potassium-transporting ATPase subunit beta-1
T3D0063 Endrin ketone Sodium/potassium-transporting ATPase subunit alpha-4
T3D0063 Endrin ketone Sodium/potassium-transporting ATPase subunit alpha-3
T3D0063 Endrin ketone Sodium/potassium-transporting ATPase subunit alpha-2
T3D0063 Endrin ketone Sodium/potassium-transporting ATPase subunit alpha-1
T3D0063 Endrin ketone Sodium/potassium-transporting ATPase subunit gamma
T3D0063 Endrin ketone Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
T3D0063 Endrin ketone Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
T3D0063 Endrin ketone Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
T3D0063 Endrin ketone Plasma membrane calcium-transporting ATPase 4
T3D0063 Endrin ketone Plasma membrane calcium-transporting ATPase 3
T3D0063 Endrin ketone Plasma membrane calcium-transporting ATPase 2
T3D0063 Endrin ketone Plasma membrane calcium-transporting ATPase 1
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit theta
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit rho-3
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit rho-2
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit rho-1
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit pi
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit gamma-3
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit gamma-2
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit gamma-1
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit epsilon
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit delta
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit beta-3
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit beta-2
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit beta-1
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit alpha-6
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit alpha-5
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit alpha-4
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit alpha-3
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit alpha-2
T3D0063 Endrin ketone Gamma-aminobutyric acid receptor subunit alpha-1
T3D0063 Endrin ketone Calcium-transporting ATPase type 2C member 2
T3D0063 Endrin ketone Calcium-transporting ATPase type 2C member 1
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