Endosulfan sulfate
描述
Endosulfan sulfate is one of the primary metabolites of endosulfan. Endosulfan is a organochlorine insecticide and acaricide. It is used to control insects on food and non-food crops and also as a wood preservative. Due to its toxicity and tendency to bioaccumulate, the use of endosulfan is banned in many areas. (L113)
类别
"Pesticide", "Pollutant", "Food Toxin", "Synthetic Toxin"
同义词
"Endosulfan sulfate solution", "Endosulfan sulfic acid", "Endosulfan sulphate", "Endosulfan sulphic acid", "Endosulphan sulphate", "Thiodan sulfate"
IUPAC 名称
1,9,10,11,12,12-hexachloro-4,6-dioxa-5lambda6-thiatricyclo[7.2.1.0^{2,8}]dodec-10-ene-5,5-dione
传统名称
1,9,10,11,12,12-hexachloro-4,6-dioxa-5lambda6-thiatricyclo[7.2.1.0^{2,8}]dodec-10-ene-5,5-dione
简化分子线性输入规范
ClC1=C(Cl)C2(Cl)C3COS(=O)(=O)OCC3C1(Cl)C2(Cl)Cl
InChI 标识符
InChI=1S/C9H6Cl6O4S/c10-5-6(11)8(13)4-2-19-20(16,17)18-1-3(4)7(5,12)9(8,14)15/h3-4H,1-2H2
键
InChIKey=AAPVQEMYVNZIOO-UHFFFAOYSA-N
大分类
Organic acids and derivatives
类型
Organic sulfuric acids and derivatives
直接大类
Sulfuric acid diesters
另外分类
"Alkyl chlorides", "Alkyl sulfates", "Chloroalkenes", "Hydrocarbon derivatives", "Organic oxides", "Organochlorides", "Organooxygen compounds", "Oxacyclic compounds", "Vinyl chlorides"
取代基
"Aliphatic heteropolycyclic compound", "Alkyl chloride", "Alkyl halide", "Alkyl sulfate", "Chloroalkene", "Haloalkene", "Hydrocarbon derivative", "Organic oxide", "Organic oxygen compound", "Organochloride", "Organohalogen compound", "Organoheterocyclic compound", "Organooxygen compound", "Oxacycle", "Sulfuric acid diester", "Vinyl chloride", "Vinyl halide"
分子框架
Aliphatic heteropolycyclic compounds
地位
Detected and Not Quantified
熔点/沸点/溶解度
181-182°C//0.00048 mg/mL at 20 °C [SHIU,WY et al. (1990)]
暴露途径
Oral (L114) ; inhalation (L114) ; dermal (L114)
毒性机制
Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of chloride ions. Endosulfan sulfate also inhibits Na+ K+ ATPase and Ca2+ and Mg2+ ATPase which are essential for the transport of calcium across membranes. This results in the accumulation of intracellular free calcium ions, which promotes release of neurotransmitters from storage vesicles, the subsequent depolarization of adjacent neurons, and the propagation of stimuli throughout the CNS. This results in hyperexcitation and generalized seizures. Endosulfan sulfate is also an endocrine disruptor and acts as an agonist at the progesterone receptor and estrogen receptors. (T10, L113, L114, A61, A114)
代谢
Endosulfan and its metabolites, which include sulfate, diol, α-hydroxyether, lactone, and ether derivatives of endosulfan, are excreted in the urine and faeces. (L114)
致癌性
No indication of carcinogenicity to humans (not listed by IARC).
用途/来源
Endosulfan is used as an insecticide, acaricide, and in wood preservatives. (L114)
健康影响
Endosulfan is a neurotoxin and damages the central nervous system, causing effects such as intermittent muscle twitching and myoclonic jerking. Endosulfan can also damage the kidneys, testes, and liver, and may possibly affect the body's ability to fight infection. It is also an endocrine disruptor and causes reproductive and developmental damage. (T10, L113, L114)
症状
Symptoms of endosulfan poisoning include hyperactivity, hyperreflexia, tremors, dizziness, headache, convulsions, lack of coordination, staggering, difficulty breathing, nausea and vomiting, diarrhea, and in severe cases, unconsciousness. (T10, L113, L114)
治疗
Treatment is symptomatic, aimed at controlling convulsions, coma, and respiratory depression. If ingested, gastric lavage may be performed, followed by administering activated charcoal powder. (L161)
维基百科链接
http://en.wikipedia.org/wiki/Endosulfan sulfate
创建于
2009-03-06 18:58:00 UTC
更新于
2014-12-24 20:20:59 UTC