Cobalt
SmallMolecule
T3DB_ID
T3D0049
描述
Cobalt has a molecular weight of 58.9 and an atomic number of 27. In the Periodic Table, close to other transition metals, it is situated in group 8, together with rhodium and iridium and it can occur in four oxidation states (0, +2, +3 and +4). The +2 and the ground state are the most common. Cobalt occurs in the minerals cobaltite (Co, Fe) AsS, smaltite (CoAs2), and erythrite Co3(AsO4)2.8H2O, and is often associated with nickel, silver, lead, copper, and iron ores, from which it is most frequently obtained as a by-product. Depending on the considered species, cobalt has multiple industrial applications including the production of alloys and hard metal, diamond polishing, drying agents, pigments and catalysts. Hard metal or cemented carbide is a powder metallurgical product consisting of hard, wear-resistant carbide particles bound together (cemented) with a ductile metal binder (i.e. metallic Co) by liquid phase sintering. Tungsten carbide (WC) is produced by mixing tungsten powder with pure carbon powder at high temperature; hereafter WC is mixed with Co powder to which paraffin is added as a binder. Depending on specific requirements related to their use, hard metals might additionally contain small quantities of chromium, niobium, molybdenum, titanium, tantalum or vanadium carbides. Inhalation and skin contact are the main occupational exposure routes. Occupational exposure to cobalt may result in adverse health effects in different organs or tissues, including the respiratory tract, the skin, the hemapoietic tissues, the myocardium or the thyroid gland. In addition, teratogenic and carcinogenic effects have been observed in experimental systems and/or in humans. For the general population, the diet constitutes the main route of exposure to cobalt, since it is an essential component of Vitamin B12 (hydroxycolalamin). Cobalt functions as a co-factor in enzyme catalysed reactions and is involved in the production of erythropoietin, a hormone that stimulates the formation of erythrocytes. This last property of cobalt was applied in the past as a therapy for anaemia. The carcinogenic potential of cobalt and its compounds was evaluated in 1991 by the International Agency for Research on Cancer (IARC), which concluded that there was inadequate evidence for carcinogenicity in humans (lung cancer) but sufficient evidence in experimental animal studies. In most experimental studies considered, the routes of exposure were, however, of questionable relevance for cancer risk assessment in humans for example, local sarcomas after intra-muscular injection. The general conclusion was that cobalt and its compounds are possibly carcinogenic to humans (group 2B). Since this evaluation, additional data have been accumulated which generally indicate that, depending on the considered cobalt species, different outcomes regarding toxicity, mutagenicity and carcinogenicity can be observed. Physiologically, it exists as an ion in the body. Co(II) ions are genotoxic in vitro and in vivo, and carcinogenic in rodents. Co metal is genotoxic in vitro. Hard metal dust, of which occupational exposure is linked to an increased lung cancer risk, is proven to be genotoxic in vitro and in vivo. Possibly, production of active oxygen species and/or DNA repair inhibition are mechanisms involved. Given the recently provided proof for in vitro and in vivo genotoxic potential of hard metal dust, the mechanistic evidence of elevated production of active oxygen species and the epidemiological data on increased cancer risk, it may be advisable to consider the possibility of a new evaluation by IARC.(A7687).
类别
"Cigarette Toxin", "Household Toxin", "Industrial/Workplace Toxin", "Pollutant", "Airborne Pollutant", "Food Toxin", "Natural Toxin"
同义词
"Co(2+)", "Co2+", "Cobalt ion", "Cobalt(2+)", "Cobalt(2+) ion", "Cobalt(II)", "Cobalt(II) cation", "Cobalt(II) ion"
CAS登记号
7440-48-4
化学式
Co
平均分子量
58.9321
单同位素质量
58.932103034
IUPAC 名称
lambda2-cobalt(2+) ion
传统名称
lambda2-cobalt(2+) ion
简化分子线性输入规范
[Co++]
InChI 标识符
InChI=1S/Co/q+2
InChIKey=XLJKHNWPARRRJB-UHFFFAOYSA-N
化合物类型
Inorganic compounds
大分类
Homogeneous metal compounds
类型
Homogeneous transition metal compounds
子类
直接大类
Homogeneous transition metal compounds
另外分类
""
取代基
"Homogeneous transition metal"
分子框架
外部描述符
"a cation", "cobalt cation", "divalent metal cation", "monoatomic dication"
地位
Detected and Not Quantified
起源
Exogenous
蜂窝位置
"Cytoplasm", "Extracellular"
生物流体位置
组织位置
"Kidney", "Skin"
途径
状态
Solid
外貌
Grey metallic solid.
熔点/沸点/溶解度
1495°C/3100°C (5612°F)/
日志P
暴露途径
Inhalation (L29) ; oral (L29) ; dermal (L29)
毒性机制
Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, causing increased lipid peroxidation, DNA damage, and inducing certain enzymes that lead to cell apoptosis. Cobalt has also been shown to block inorganic calcium channels, possibly impairing neurotransmission. Cobalt can also chelate lipoic acids, impairing oxidation of pyruvate or fatty acids. In addition, cobalt may inhibit DNA repair by interacting with zinc finger DNA repair proteins, and has also been shown to inhibit heme synthesis and glucose metabolism. Cobalt may activate specific helper T-lymphocyte cells and interact directly with immunologic proteins, such as antibodies (IgA and IgE) or Fc receptors, resulting in immunosensitization. (L29)
代谢
Cobalt is absorbed though the lungs, gastrointestinal tract, and skin. Since it is a component of the vitamin B12 (cyanocobalamin), it is distributed to most tissues of the body. It is transported in the blood, often bound to albumin, with the highest levels being found in the liver and kidney. Cobalt is excreted mainly in the urine and faeces. (L29)
毒性值
LD50: 6170 mg/kg (Oral, Rat) (T26) LD50: 100 mg/kg (Intraperitoneal, Rat) (T26)
致死剂量
1 to 2 mg/m3 for an adult human. (L138)
致癌性
Cobalt metal with tungsten carbide: 2A, probably carcinogenic to humans. Cobalt metal without tungsten carbide: 2B, posiibly carcinogenic to humans. (L135)
用途/来源
Cobalt is used to produce alloys used in the manufacture of aircraft engines, magnets, grinding and cutting tools, artificial hip and knee joints. Cobalt compounds are also used to color glass, ceramics and paints, and used as a drier for porcelain enamel and paints.
最低风险等级
Chronic Inhalation: 0.0001 mg/m3 (L134) Intermediate Oral: 0.01 mg/kg/day (L134)
健康影响
Exposure to high amount of cobalt can cause heart, lung, kidney, and liver damage. Skin contact is known to result in contact dermatitis. Cobalt may also have mutagenic and carcinogenic effects. (L29, L30)
症状
Cobalt inhalation can cause asthma-like breathing problems. Skin contact is known to result in contact dermatitis, which is characterized by irritation and rashes. Ingesting large amounts of cobalt may cause nausea and vomiting. (L2090)
治疗
Treatment of cobalt poisoning is symptomatic. (L29)
药库 ID
HMDB_ID
HMDB00608
PubChem 化合物 ID
104729
维基百科链接
http://en.wikipedia.org/wiki/Cobalt
创建于
2009-03-06 18:57:59 UTC
更新于
2014-12-24 20:20:58 UTC
目标
毒素T3DB ID毒素名称目标名称
T3D0049 Cobalt Histone deacetylase 8
T3D0049 Cobalt Estrogen receptor alpha
T3D0049 Cobalt Fas-binding factor 1
T3D0049 Cobalt DNA
T3D0049 Cobalt Voltage-dependent R-type calcium channel subunit alpha-1E
T3D0049 Cobalt Voltage-dependent P/Q-type calcium channel subunit alpha-1A
T3D0049 Cobalt Voltage-dependent N-type calcium channel subunit alpha-1B
T3D0049 Cobalt Voltage-dependent L-type calcium channel subunit beta-4
T3D0049 Cobalt Voltage-dependent L-type calcium channel subunit beta-3
T3D0049 Cobalt Voltage-dependent L-type calcium channel subunit beta-2
T3D0049 Cobalt Voltage-dependent L-type calcium channel subunit beta-1
T3D0049 Cobalt Voltage-dependent L-type calcium channel subunit alpha-1S
T3D0049 Cobalt Voltage-dependent L-type calcium channel subunit alpha-1F
T3D0049 Cobalt Voltage-dependent L-type calcium channel subunit alpha-1D
T3D0049 Cobalt Voltage-dependent calcium channel subunit alpha-2/delta-4
T3D0049 Cobalt Voltage-dependent calcium channel subunit alpha-2/delta-3
T3D0049 Cobalt Voltage-dependent calcium channel subunit alpha-2/delta-2
T3D0049 Cobalt Voltage-dependent calcium channel subunit alpha-2/delta-1
T3D0049 Cobalt Voltage-dependent calcium channel gamma-like subunit
T3D0049 Cobalt Voltage-dependent calcium channel gamma-8 subunit
T3D0049 Cobalt Voltage-dependent calcium channel gamma-7 subunit
T3D0049 Cobalt Voltage-dependent calcium channel gamma-6 subunit
T3D0049 Cobalt Voltage-dependent calcium channel gamma-5 subunit
T3D0049 Cobalt Voltage-dependent calcium channel gamma-4 subunit
T3D0049 Cobalt Voltage-dependent calcium channel gamma-3 subunit
T3D0049 Cobalt Voltage-dependent calcium channel gamma-2 subunit
T3D0049 Cobalt Voltage-dependent calcium channel gamma-1 subunit
T3D0049 Cobalt 5-aminolevulinate synthase, nonspecific, mitochondrial
T3D0049 Cobalt 5-aminolevulinate synthase, erythroid-specific, mitochondrial
T3D0049 Cobalt Poly [ADP-ribose] polymerase 1
T3D0049 Cobalt DNA repair protein complementing XP-A cells
T3D0049 Cobalt Ig alpha-1 chain C region
T3D0049 Cobalt Ig alpha-2 chain C region
T3D0049 Cobalt Ig epsilon chain C region
T3D0049 Cobalt Voltage-dependent L-type calcium channel subunit alpha-1C
T3D0049 Cobalt Carbonic anhydrase 4
T3D0049 Cobalt Carbonic anhydrase 2
T3D0049 Cobalt Carbonic anhydrase 1
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