Carbon tetrachloride
SmallMolecule
T3DB_ID
T3D0047
描述
Grain fumigantCarbon tetrachloride has been shown to exhibit anesthetic, metal chelator and hepatoprotective functions (A7684, A7685, A7686).Carbon tetrachloride belongs to the family of Chlorocarbons. These are Any Compound consisting wholly of chlorine and carbon. (Reference: [1] IUPAC. Compendium of Chemical Terminology, 2nd ed. (the Gold Book). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8. doi:10.1351/goldbook. (Or PAC, 1995, 67, 1307 (Glossary of class names of organic compounds and reactivity intermediates based on structure (IUPAC Recommendations 1995)) on page 1328)).
类别
"Pesticide", "Household Toxin", "Industrial/Workplace Toxin", "Pollutant", "Airborne Pollutant", "Food Toxin", "Synthetic Toxin"
同义词
"Carbon chloride", "Carbon tet", "Carbontetrachloride", "Methane tetrachloride", "Necatorine", "Perchloromethane", "Tetrachloro-Methane", "Tetrachloromethane", "Tetrasol"
CAS登记号
56-23-5
化学式
CCl4
平均分子量
153.823
单同位素质量
151.875410828
IUPAC 名称
tetrachloromethane
传统名称
carbon tetrachloride
简化分子线性输入规范
ClC(Cl)(Cl)Cl
InChI 标识符
InChI=1S/CCl4/c2-1(3,4)5
InChIKey=VZGDMQKNWNREIO-UHFFFAOYSA-N
化合物类型
Organic compounds
大分类
Organohalogen compounds
类型
Alkyl halides
子类
Halomethanes
直接大类
Halomethanes
另外分类
"Alkyl chlorides", "Hydrocarbon derivatives", "Organochlorides"
取代基
"Aliphatic acyclic compound", "Alkyl chloride", "Halomethane", "Hydrocarbon derivative", "Organochloride"
分子框架
Aliphatic acyclic compounds
外部描述符
"a small molecule", "chlorocarbon", "chloromethanes", "one-carbon compound"
地位
Detected and Not Quantified
起源
Exogenous
蜂窝位置
"Membrane"
生物流体位置
组织位置
途径
状态
Solid
外貌
Clear liquid.
熔点/沸点/溶解度
28.6°C//0.793 mg/mL at 25°C
日志P
2.83
暴露途径
Oral (L129) ; inhalation (L129) ; dermal (L129)
毒性机制
Unmetabolized carbon tetrachloride, depresses the central nervous system. All other toxic effects of carbon tetrachloride are related to its biotransformation via cytochrome P-450 enzymes, specifically CYP2E1. Metabolism of carbon tetrachloride by CYP2E1 may result in the destruction of the enzyme during the metabolic process, either by direct attack of radicals on the cytochrome(s) or highly localized lipid peroxidation resulting in detachment of P-450 proteins from the microsomal membranes. Reactive metabolites of carbon tetrachloride causes hepatic damage via haloalkylation of cellular macromolecules and lipid peroxidation. Carbon tetrachloride also perturbs the intracellular calcium homeostasis. Increased cytosolic levels of calcium may result from an influx of extracellular calcium caused by plasma membrane damage and decreased intracellular calcium sequestering. Higher levels of calcium activate enzymes such as proteases, which hydrolyze proteins in neighboring cells, leading to a progression of the lesion. Carbon tetrachloride's carcinogenicity is likely the result of certain reactive metabolites that bind to nuclear proteins, lipids, and DNA. (T10, L129)
代谢
Carbon tetrachloride is absorbed readily from the gastrointestinal and respiratory tracts, and more slowly through the skin. It is distributed to all major organs, with highest concentrations in the fat, liver, bone marrow, adrenals, blood, brain, spinal cord, and kidney. Once carbon tetrachloride is absorbed, it is metabolized by cytochrome P-450 enzymes, with the production of the trichloromethyl radical. Aerobically, metabolism of the trichloromethyl radical can eventually form phosgene. Anaerobically, the radical can undergo reactions to form chloroform, hexachloroethane, or carbon monoxide. Carbon tetrachloride is excreted primarily in exhaled air and in the feces, with relatively minimal amounts in the urine. (L129)
毒性值
LD50: 2800 mg/kg (Oral, Rat) (T21)
致死剂量
1700 to 1800 mg/kg for an adult human. (T26)
致癌性
2B, possibly carcinogenic to humans. (L135)
用途/来源
Carbon tetrachloride was used in the production of refrigeration fluid and propellants for aerosol cans, as a pesticide, as a cleaning fluid and degreasing agent, in fire extinguishers, and in spot removers. (L129)
最低风险等级
Intermediate Inhalation: 0.03 ppm (L134) Chronic Inhalation: 0.03 ppm (L134) Acute Oral: 0.02 mg/kg/day (L134) Intermediate Oral: 0.007 mg/kg/day (L134)
健康影响
High exposure to carbon tetrachloride can cause liver, kidney, and central nervous system damage. Single cell necrosis, which is evident after 5h to 6h after dosing, progresses to maximal centrilobular necrosis within 24h to 48h. Cellular regeneration is maximal 36h to 48h after dosing. The rate and extent of tissue repair are important determinants of the ultimate outcome of liver injury. In severe cases, coma and even death may occur. (T10, L129)
症状
Carbon tetrachloride exposure causes headaches, dizziness, sleepiness, nausea, and vomiting. (L129)
治疗
药库 ID
HMDB_ID
HMDB31330
PubChem 化合物 ID
5943
维基百科链接
http://en.wikipedia.org/wiki/Carbon_tetrachloride
创建于
2009-03-06 18:57:59 UTC
更新于
2014-12-24 20:20:58 UTC
目标
毒素T3DB ID毒素名称目标名称
T3D0047 Carbon tetrachloride Estrogen receptor beta
T3D0047 Carbon tetrachloride Estrogen receptor alpha
T3D0047 Carbon tetrachloride Sodium/potassium-transporting ATPase subunit beta-3
T3D0047 Carbon tetrachloride Sodium/potassium-transporting ATPase subunit beta-2
T3D0047 Carbon tetrachloride Sodium/potassium-transporting ATPase subunit beta-1
T3D0047 Carbon tetrachloride Sodium/potassium-transporting ATPase subunit alpha-4
T3D0047 Carbon tetrachloride Sodium/potassium-transporting ATPase subunit alpha-3
T3D0047 Carbon tetrachloride Sodium/potassium-transporting ATPase subunit alpha-2
T3D0047 Carbon tetrachloride Sodium/potassium-transporting ATPase subunit alpha-1
T3D0047 Carbon tetrachloride Sodium/potassium-transporting ATPase subunit gamma
T3D0047 Carbon tetrachloride Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
T3D0047 Carbon tetrachloride Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
T3D0047 Carbon tetrachloride Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
T3D0047 Carbon tetrachloride Plasma membrane calcium-transporting ATPase 4
T3D0047 Carbon tetrachloride Plasma membrane calcium-transporting ATPase 3
T3D0047 Carbon tetrachloride Plasma membrane calcium-transporting ATPase 2
T3D0047 Carbon tetrachloride Plasma membrane calcium-transporting ATPase 1
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit theta
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit rho-3
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit rho-2
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit rho-1
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit pi
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit gamma-3
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit gamma-2
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit gamma-1
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit epsilon
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit delta
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit beta-3
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit beta-2
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit beta-1
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit alpha-6
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit alpha-5
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit alpha-4
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit alpha-3
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit alpha-2
T3D0047 Carbon tetrachloride Gamma-aminobutyric acid receptor subunit alpha-1
T3D0047 Carbon tetrachloride Calcium-transporting ATPase type 2C member 2
T3D0047 Carbon tetrachloride Calcium-transporting ATPase type 2C member 1
T3D0047 Carbon tetrachloride DNA
T3D0047 Carbon tetrachloride Cytochrome P450 2E1
免责声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责,医药网对此不承担任何责任。
相关链接:医药研究数据| 医药资料| SDA药品评审中心| 中医网| 中药处方系统| 爱视立眼贴
专业提供药品信息、药品招商、药品代理、保健品招商、医药原料采购供应的中国药品信息网站平台
版权所有 © 2003-2028 盗冒必究  客服热线:0575-83552251 / 13754370441  QQ客服:药品信息客服
浙ICP备16010490号-2 增值电信业务经营许可证:浙B2-20220931 互联网药品信息服务资格证书编号:(浙)-经营性2023-0215 浙公网安备:330683240604819103159
 医药代理商群1:药药网药品采购交流医药代理商群2:药药网药品采购交流2医药代理商群3:药药网药品采购交流3