Heptachlor epoxide
SmallMolecule
T3DB_ID
T3D0046
描述
Heptachlor epoxide is a chemical produced when heptachlor is broken down by bacteria and animals. Heptachlor is a manufactured cyclodiene organochlorine insecticide. As it is a persistant organic pollutant, heptachlor use is banned or limited in most areas. The epoxide is more likely to be found in the environment than heptachlor. (L118, L119)
类别
"Pesticide", "Pollutant", "Synthetic Toxin"
同义词
"b-heptachlorepoxide", "Epoxyheptachlor", "Heptachlore epoxide"
CAS登记号
1024-57-3
化学式
C10H5Cl7O
平均分子量
389.317
单同位素质量
385.816008731
IUPAC 名称
1,6,8,9,10,11,11-heptachloro-4-oxatetracyclo[6.2.1.0²,⁷.0³,⁵]undec-9-ene
传统名称
heptachlor epoxide
简化分子线性输入规范
ClC1C2OC2C2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl
InChI 标识符
InChI=1S/C10H5Cl7O/c11-3-1-2(4-5(3)18-4)9(15)7(13)6(12)8(1,14)10(9,16)17/h1-5H
InChIKey=ZXFXBSWRVIQKOD-UHFFFAOYSA-N
化合物类型
Organic compounds
大分类
Organoheterocyclic compounds
类型
Oxanes
子类
直接大类
Oxanes
另外分类
"Alkyl chlorides", "Chloroalkenes", "Dialkyl ethers", "Epoxides", "Hydrocarbon derivatives", "Organochlorides", "Oxacyclic compounds", "Vinyl chlorides"
取代基
"Aliphatic heteropolycyclic compound", "Alkyl chloride", "Alkyl halide", "Chloroalkene", "Dialkyl ether", "Ether", "Haloalkene", "Hydrocarbon derivative", "Organic oxygen compound", "Organochloride", "Organohalogen compound", "Organooxygen compound", "Oxacycle", "Oxane", "Oxirane", "Vinyl chloride", "Vinyl halide"
分子框架
Aliphatic heteropolycyclic compounds
外部描述符
"Organochlorine pesticides", "oxanes"
地位
Detected and Not Quantified
起源
Exogenous
蜂窝位置
"Membrane"
生物流体位置
组织位置
途径
状态
Solid
外貌
White powder.
熔点/沸点/溶解度
160°C//0.0002 mg/mL at 25 °C [BIGGAR,JW & RIGGS,RI (1974)]
日志P
暴露途径
Oral (L118) ; inhalation (L118) ; dermal (L118)
毒性机制
Heptachlor epoxide is a central nervous system stimulant. It non-competitively blocks neurotransmitter action at gamma-amino butyric acid receptors, resulting in overstimulation of the nervous system. Heptachlor epoxide is also believed to exert carcinogenic effects by activating key kinases in signalling pathways and inhibiting apoptosis. (L118, A81, A82)
代谢
Heptachlor epoxide is readily absorbed by the skin, lungs and gastrointestinal tract and excreted in the urine and faeces. (L118)
毒性值
致死剂量
致癌性
No indication of carcinogenicity (not listed by IARC). (L135)
用途/来源
Heptachlor epoxide is a chemical produced when heptachlor is broken down by bacteria and animals. Heptachlor was originally widely produced as an insecticide, but is now used only in fire and control in underground transformers. (L118)
最低风险等级
健康影响
Exposure to heptachlor epoxide may cause damage to liver, nervous system, and immune system. (L118)
症状
Heptachlor epoxide poisoning may cause convulsions, vomiting, seizures, confusion, incoordination, excitability, coma, hypotension, and respiratory failure. (L118)
治疗
Treatment is symptomatic and is aimed at controlling convulsions, coma, and respiratory depression. (L118)
药库 ID
HMDB_ID
PubChem 化合物 ID
13930
维基百科链接
创建于
2009-03-06 18:57:59 UTC
更新于
2014-12-24 20:20:58 UTC
目标
毒素T3DB ID毒素名称目标名称
T3D0046 Heptachlor epoxide Estrogen receptor beta
T3D0046 Heptachlor epoxide Estrogen receptor alpha
T3D0046 Heptachlor epoxide Sodium/potassium-transporting ATPase subunit beta-3
T3D0046 Heptachlor epoxide Sodium/potassium-transporting ATPase subunit beta-2
T3D0046 Heptachlor epoxide Sodium/potassium-transporting ATPase subunit beta-1
T3D0046 Heptachlor epoxide Sodium/potassium-transporting ATPase subunit alpha-4
T3D0046 Heptachlor epoxide Sodium/potassium-transporting ATPase subunit alpha-3
T3D0046 Heptachlor epoxide Sodium/potassium-transporting ATPase subunit alpha-2
T3D0046 Heptachlor epoxide Sodium/potassium-transporting ATPase subunit alpha-1
T3D0046 Heptachlor epoxide Sodium/potassium-transporting ATPase subunit gamma
T3D0046 Heptachlor epoxide Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
T3D0046 Heptachlor epoxide Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
T3D0046 Heptachlor epoxide Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
T3D0046 Heptachlor epoxide Plasma membrane calcium-transporting ATPase 4
T3D0046 Heptachlor epoxide Plasma membrane calcium-transporting ATPase 3
T3D0046 Heptachlor epoxide Plasma membrane calcium-transporting ATPase 2
T3D0046 Heptachlor epoxide Plasma membrane calcium-transporting ATPase 1
T3D0046 Heptachlor epoxide Calcium-transporting ATPase type 2C member 2
T3D0046 Heptachlor epoxide Calcium-transporting ATPase type 2C member 1
T3D0046 Heptachlor epoxide Cytochrome P450 2B6
T3D0046 Heptachlor epoxide Nuclear receptor subfamily 1 group I member 2
T3D0046 Heptachlor epoxide Bile acid receptor
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit epsilon
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit theta
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit rho-3
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit rho-2
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit rho-1
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit pi
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit gamma-3
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit gamma-2
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit gamma-1
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit delta
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit beta-3
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit beta-2
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit beta-1
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit alpha-6
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit alpha-5
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit alpha-4
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit alpha-3
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit alpha-2
T3D0046 Heptachlor epoxide Gamma-aminobutyric acid receptor subunit alpha-1
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