Heptachlor epoxide
描述
Heptachlor epoxide is a chemical produced when heptachlor is broken down by bacteria and animals. Heptachlor is a manufactured cyclodiene organochlorine insecticide. As it is a persistant organic pollutant, heptachlor use is banned or limited in most areas. The epoxide is more likely to be found in the environment than heptachlor. (L118, L119)
类别
"Pesticide", "Pollutant", "Synthetic Toxin"
同义词
"b-heptachlorepoxide", "Epoxyheptachlor", "Heptachlore epoxide"
IUPAC 名称
1,6,8,9,10,11,11-heptachloro-4-oxatetracyclo[6.2.1.0²,⁷.0³,⁵]undec-9-ene
简化分子线性输入规范
ClC1C2OC2C2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl
InChI 标识符
InChI=1S/C10H5Cl7O/c11-3-1-2(4-5(3)18-4)9(15)7(13)6(12)8(1,14)10(9,16)17/h1-5H
键
InChIKey=ZXFXBSWRVIQKOD-UHFFFAOYSA-N
大分类
Organoheterocyclic compounds
另外分类
"Alkyl chlorides", "Chloroalkenes", "Dialkyl ethers", "Epoxides", "Hydrocarbon derivatives", "Organochlorides", "Oxacyclic compounds", "Vinyl chlorides"
取代基
"Aliphatic heteropolycyclic compound", "Alkyl chloride", "Alkyl halide", "Chloroalkene", "Dialkyl ether", "Ether", "Haloalkene", "Hydrocarbon derivative", "Organic oxygen compound", "Organochloride", "Organohalogen compound", "Organooxygen compound", "Oxacycle", "Oxane", "Oxirane", "Vinyl chloride", "Vinyl halide"
分子框架
Aliphatic heteropolycyclic compounds
外部描述符
"Organochlorine pesticides", "oxanes"
地位
Detected and Not Quantified
熔点/沸点/溶解度
160°C//0.0002 mg/mL at 25 °C [BIGGAR,JW & RIGGS,RI (1974)]
暴露途径
Oral (L118) ; inhalation (L118) ; dermal (L118)
毒性机制
Heptachlor epoxide is a central nervous system stimulant. It non-competitively blocks neurotransmitter action at gamma-amino butyric acid receptors, resulting in overstimulation of the nervous system. Heptachlor epoxide is also believed to exert carcinogenic effects by activating key kinases in signalling pathways and inhibiting apoptosis. (L118, A81, A82)
代谢
Heptachlor epoxide is readily absorbed by the skin, lungs and gastrointestinal tract and excreted in the urine and faeces. (L118)
致癌性
No indication of carcinogenicity (not listed by IARC). (L135)
用途/来源
Heptachlor epoxide is a chemical produced when heptachlor is broken down by bacteria and animals. Heptachlor was originally widely produced as an insecticide, but is now used only in fire and control in underground transformers. (L118)
健康影响
Exposure to heptachlor epoxide may cause damage to liver, nervous system, and immune system. (L118)
症状
Heptachlor epoxide poisoning may cause convulsions, vomiting, seizures, confusion, incoordination, excitability, coma, hypotension, and respiratory failure. (L118)
治疗
Treatment is symptomatic and is aimed at controlling convulsions, coma, and respiratory depression. (L118)
创建于
2009-03-06 18:57:59 UTC
更新于
2014-12-24 20:20:58 UTC