类

SmallMolecule

T3DB_ID

T3D0034

描述

Heptachlor is a manufactured cyclodiene organochlorine insecticide. As it is a persistant organic pollutant, heptachlor use is banned or limited in most areas. It is one ingredient of cigarette. (L118, L119)

类别

"Cigarette Toxin", "Pesticide", "Pollutant", "Airborne Pollutant", "Synthetic Toxin"

同义词

"1,4,5,6,7,8,8-Heptachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene", "1,4,5,6,7,8,8-Heptachlorotetrahydro-4,7-methanoindene", "1,5,7,8,9,10,10-Heptachlorotricyclo[5.2.1.0(2,6)]deca-3,8-diene", "3,4,5,6,7,8,8-A-heptachloro-alpha-Dicyclopentadiene", "3,4,5,6,7,8,8-Heptachlorodicyclopentadiene", "3,4,5,6,7,8,8a-Heptachlorodicyclopentadiene", "3-Chlorochlordene", "Aahepta", "Agroceres", "Arbinex 30TN", "Basaklor", "Drinox", "Drinox H-34", "Heptachlorane", "Heptachlore", "Heptachlorotetrahydro-4,7-methanoindene", "Heptagran", "Heptagranox", "Heptaklor", "Heptamak", "Heptamul", "Heptasol", "Heptox", "Soleptax", "Tetrahydro", "Velsicol heptachlor"

CAS登记号

76-44-8

化学式

C10H5Cl7

平均分子量

373.318

单同位素质量

369.821094109

IUPAC 名称

1,5,7,8,9,10,10-heptachlorotricyclo[5.2.1.0²,⁶]deca-3,8-diene

传统名称

heptachlor

简化分子线性输入规范

ClC1C=CC2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl

InChI 标识符

InChI=1S/C10H5Cl7/c11-4-2-1-3-5(4)9(15)7(13)6(12)8(3,14)10(9,16)17/h1-5H

键

InChIKey=FRCCEHPWNOQAEU-UHFFFAOYSA-N

化合物类型

Organic compounds

大分类

Organohalogen compounds

类型

Vinyl halides

子类

Vinyl chlorides

直接大类

Vinyl chlorides

另外分类

"Alkyl chlorides", "Chloroalkenes", "Hydrocarbon derivatives", "Organochlorides"

取代基

"Aliphatic homopolycyclic compound", "Alkyl chloride", "Alkyl halide", "Chloroalkene", "Haloalkene", "Hydrocarbon derivative", "Organochloride", "Vinyl chloride"

分子框架

Aliphatic homopolycyclic compounds

外部描述符

"Organochlorine insecticides", "Organochlorine pesticides", "cyclodiene organochlorine insecticide"

地位

Detected and Not Quantified

起源

Exogenous

蜂窝位置

"Membrane"

生物流体位置

组织位置

途径

状态

Solid

外貌

White or tan powder.

熔点/沸点/溶解度

95.5°C/135-145°C at 1-1.5 mmHg/0.00018 mg/mL at 25 °C [BIGGAR,JW & RIGGS,RI (1974)]

日志P

暴露途径

Oral (L116) ; inhalation (L116) ; dermal (L116)

毒性机制

Heptachlor is a central nervous system stimulant. It non-competitively blocks neurotransmitter action at gamma-amino butyric acid receptors, resulting in overstimulation of the nervous system. Heptachlor is also believed to exert carcinogenic effects by activating key kinases in signalling pathways and inhibiting apoptosis. (L118, A81, A82)

代谢

Heptachlor is readily absorbed by the skin, lungs and gastrointestinal tract. It is readily metabolized by liver microsomes into heptachlor epoxide, its most persistent and toxic metabolite, which is mainly stored in adipose tissue. Heptachlor epoxide is excreted in the urine and faeces. (L118)

毒性值

LC50: 150 mg/kg over 4 hours (Inhalation, Cat) (T20) LD50: 500-2000 mg/kg (Dermal, Rabbit) (T20) LD50: 80-90 mg/kg (Oral, Rabbit) (T20) LD50: 27 mg/kg (Intraperitoneal, Rat) (T20)

致死剂量

致癌性

2B, possibly carcinogenic to humans. (L135)

用途/来源

Heptachlor was originally widely produced as an insecticide, but is now used only in fire and control in underground transformers. (L118)

最低风险等级

Acute Oral: 0.0006 mg/kg/day (L134) Intermediate Oral: 0.0001 mg/kg/day (L134)

健康影响

Exposure to heptachlor may cause damage to your liver, nervous system, and immune system. (L118)

症状

Heptachlor poisoning may cause convulsions, vomiting, seizures, confusion, incoordination, excitability, coma, hypotension, and respiratory failure. (L118)

治疗

Treatment is symptomatic and is aimed at controlling convulsions, coma, and respiratory depression. (L118)

药库 ID

HMDB_ID

PubChem 化合物 ID

3589

维基百科链接

http://en.wikipedia.org/wiki/Heptachlor

创建于

2009-03-06 18:57:57 UTC

更新于

2014-12-24 20:20:56 UTC

目标

毒素T3DB ID	毒素名称	目标名称
T3D0034	Heptachlor	Estrogen receptor beta
T3D0034	Heptachlor	Estrogen receptor alpha
T3D0034	Heptachlor	Sodium/potassium-transporting ATPase subunit beta-3
T3D0034	Heptachlor	Sodium/potassium-transporting ATPase subunit beta-2
T3D0034	Heptachlor	Sodium/potassium-transporting ATPase subunit beta-1
T3D0034	Heptachlor	Sodium/potassium-transporting ATPase subunit alpha-4
T3D0034	Heptachlor	Sodium/potassium-transporting ATPase subunit alpha-3
T3D0034	Heptachlor	Sodium/potassium-transporting ATPase subunit alpha-2
T3D0034	Heptachlor	Sodium/potassium-transporting ATPase subunit alpha-1
T3D0034	Heptachlor	Sodium/potassium-transporting ATPase subunit gamma
T3D0034	Heptachlor	Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
T3D0034	Heptachlor	Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
T3D0034	Heptachlor	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
T3D0034	Heptachlor	Plasma membrane calcium-transporting ATPase 4
T3D0034	Heptachlor	Plasma membrane calcium-transporting ATPase 3
T3D0034	Heptachlor	Plasma membrane calcium-transporting ATPase 2
T3D0034	Heptachlor	Plasma membrane calcium-transporting ATPase 1
T3D0034	Heptachlor	Calcium-transporting ATPase type 2C member 2
T3D0034	Heptachlor	Calcium-transporting ATPase type 2C member 1
T3D0034	Heptachlor	Retinoic acid receptor gamma-2
T3D0034	Heptachlor	Nuclear receptor subfamily 1 group I member 2
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit epsilon
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit theta
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit rho-3
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit rho-2
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit rho-1
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit pi
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit gamma-3
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit gamma-2
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit gamma-1
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit delta
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit beta-3
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit beta-2
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit beta-1
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit alpha-6
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit alpha-5
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit alpha-4
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit alpha-3
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit alpha-2
T3D0034	Heptachlor	Gamma-aminobutyric acid receptor subunit alpha-1