描述
Hexachlorobutadiene is a man-made chemical primarily produced as a by-product in the production of carbon tetrachloride and tetrachloroethene. It is also used to make rubber compounds, lubricants, in gyroscopes, as a heat transfer liquid, as a hydraulic fluid, and as a solvent.
(L93, L94)
类别
"Industrial/Workplace Toxin", "Pollutant", "Airborne Pollutant", "Synthetic Toxin"
同义词
"1,1,2,3,4, 4-Hexachloro-1,3-butadiene", "1,1,2,3,4,4-hexachloro-1,3-Butadiene", "1,1,2,3,4,4-Hexachloro-buta-1,3-diene", "1,1,2,3,4,4-hexachlorobuta-1,3-diene", "1,3-Hexachlorobutadiene", "Dolen-pur", "HCB", "HCBD", "Hexachlorbutadiene", "Hexachloro-1,3-Butadiene", "Hexachloro-Butadiene", "Hexachlorobuta-1,3-diene", "Hexachlorobutadiene-(1,3)", "Hexachlorobutadiene13", "Perchloro-1,3-butadiene", "Perchlorobutadiene"
取代基
"Aliphatic acyclic compound", "Chloroalkene", "Haloalkene", "Hydrocarbon derivative", "Organochloride", "Vinyl chloride"
毒性机制
It is believed that intermediates produced by modification of the S- 1,1,2,3,4-pentachlorodienyl cysteine derivative metabolite by gamma-glutamyltransferase are responsible for the observed effects on the proximal tubules of the nephrons. These metabolites uncouple oxidative phosphorylation, preventing the generation of ATP, and also inhibit cytochrome c-cytochrome oxidase activity and electron transport. The carcinogenic properties of hexachlorobutadiene are proposed to result from binding of the sulfenic acid degradation product or a thioketene intermediate to cellular DNA. The binding of hexachlorobutadiene to alpha 2u-globulin is believed to be an important factor in its nephrotoxicity. (L94, A54)
代谢
After absorption, most of the hexachlorobutadiene is carried to the liver, where it is metabolized by a glutathione-mediated pathway. It is initially bioactivated to S-glutathione conjugates which may later be metabolized further by beta-lyases and other enzymes. Hexachlorobutadiene and its metabolites preferentially distribute to the kidney, liver, adipose deposits, and possibly the brain. Metabolites are eventually excreted in the urine and faeces. (L94)
毒性值
LD50: 90 mg/kg (Oral, Rat) (T14)
LD50: 175 mg/kg (Intraperitoneal, Rat) (T14)
LD50: 1211 mg/kg (Dermal, Rabbit) (T14)
用途/来源
Hexachlorobutadiene is primarily produced as a by-product in the production of carbon tetrachloride and tetrachloroethene. It is also used to make rubber compounds, lubricants, in gyroscopes, as a heat transfer liquid, as a hydraulic fluid, and as a solvent. (L94)
健康影响
Hexachlorobutadiene is damaging to the liver and kidney, and may result in fatty liver degeneration, epithelial necrotizing nephritis, central nervous system depression and cyanosis.
(L93, L94)