Sodium arsenite
描述
Sodium arsenite is a chemical compound derived from arsenous acid. Arsenous acid is the hydrolyzed form of arsenic trioxide and is found in aqueous solutions. (L377)
类别
"Industrial/Workplace Toxin", "Pollutant", "Airborne Pollutant", "Synthetic Toxin"
同义词
"Penite", "Prodalumnol", "Sodanit", "Sodium (meta)arsenite", "Sodium dioxoarsenate", "Sodium meta-arsenite", "Sodium metaarsenite"
IUPAC 名称
(arsorosooxy)sodium
InChI 标识符
InChI=1S/AsHO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1
键
InChIKey=PTLRDCMBXHILCL-UHFFFAOYSA-M
化合物类型
Inorganic compounds
大分类
Mixed metal/non-metal compounds
另外分类
"Inorganic arsenic compounds", "Inorganic oxides", "Inorganic sodium salts", "Metalloid salts"
取代基
"Inorganic arsenic compound", "Inorganic metalloid salt", "Inorganic oxide", "Inorganic salt", "Inorganic sodium salt", "Metalloid oxide"
外部描述符
"Inorganic rodenticides", "a small molecule", "arsenic molecular entity", "inorganic sodium salt"
地位
Detected and Not Quantified
蜂窝位置
"Cytoplasm", "Extracellular"
暴露途径
Oral (L2) ; inhalation (L2) ; dermal (L2)
毒性机制
Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)
代谢
Arsenic is absorbed mainly by inhalation or ingestion, as to a lesser extent, dermal exposure. It is then distributed throughout the body, where it is reduced into arsenite if necessary, then methylated into monomethylarsenic (MMA) and dimethylarsenic acid (DMA) by arsenite methyltransferase. Arsenic and its metabolites are primarily excreted in the urine. Arsenic is known to induce the metal-binding protein metallothionein, which decreases the toxic effects of arsenic and other metals by binding them and making them biologically inactive, as well as acting as an antioxidant. (L20)
毒性值
LD50: 41 mg/kg (Oral, Rat) (T14)
LD50: 150 mg/kg (Dermal, Rat) (T14)
LD50: 1170 ug/kg (Intraperitoneal, Mouse) (T14)
LD50: 14 mg/kg (Intramuscular Mouse) (T14)
LD50: 7600 ug/kg (Intravenous, Rabbit) (T14)
致癌性
1, carcinogenic to humans. (L135)
最低风险等级
Acute Oral: 0.005 mg/kg/day (L134)
Chronic Oral: 0.0003 mg/kg/day (L134)
Chronic Inhalation: 0.01 mg/m3 (L134)
健康影响
Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, especially in skin, liver, bladder and lung cancers. (T1, L20)
症状
Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels.
治疗
Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)
维基百科链接
http://en.wikipedia.org/wiki/sodium arsenite
创建于
2009-03-06 18:58:21 UTC
更新于
2014-12-24 20:21:24 UTC
目标
| 毒素T3DB ID | 毒素名称 | 目标名称 |
|---|
| T3D0243 |
Sodium arsenite |
Tubulin beta-8 chain-like protein LOC260334 |
| T3D0243 |
Sodium arsenite |
Tubulin beta-8 chain |
| T3D0243 |
Sodium arsenite |
Tubulin beta-6 chain |
| T3D0243 |
Sodium arsenite |
Tubulin beta-4A chain |
| T3D0243 |
Sodium arsenite |
Tubulin beta-3 chain |
| T3D0243 |
Sodium arsenite |
Tubulin beta-4B chain |
| T3D0243 |
Sodium arsenite |
Tubulin beta-2B chain |
| T3D0243 |
Sodium arsenite |
Tubulin beta-2A chain |
| T3D0243 |
Sodium arsenite |
Tubulin beta-1 chain |
| T3D0243 |
Sodium arsenite |
Tubulin alpha-8 chain |
| T3D0243 |
Sodium arsenite |
Tubulin alpha-4A chain |
| T3D0243 |
Sodium arsenite |
Tubulin alpha-3E chain |
| T3D0243 |
Sodium arsenite |
Tubulin alpha-3C/D chain |
| T3D0243 |
Sodium arsenite |
Tubulin alpha-1C chain |
| T3D0243 |
Sodium arsenite |
Tubulin alpha-1B chain |
| T3D0243 |
Sodium arsenite |
Tubulin alpha-1A chain |
| T3D0243 |
Sodium arsenite |
Tubulin alpha chain-like 3 |
| T3D0243 |
Sodium arsenite |
Pyruvate dehydrogenase protein X component, mitochondrial |
| T3D0243 |
Sodium arsenite |
Putative tubulin-like protein alpha-4B |
| T3D0243 |
Sodium arsenite |
Putative tubulin beta-4q chain |
| T3D0243 |
Sodium arsenite |
Putative tubulin beta chain-like protein ENSP00000290377 |
| T3D0243 |
Sodium arsenite |
Thioredoxin reductase 3 |
| T3D0243 |
Sodium arsenite |
Thioredoxin reductase 2, mitochondrial |
| T3D0243 |
Sodium arsenite |
Thioredoxin reductase 1, cytoplasmic |
| T3D0243 |
Sodium arsenite |
Actin, cytoplasmic 2 |
| T3D0243 |
Sodium arsenite |
Actin, cytoplasmic 1 |
| T3D0243 |
Sodium arsenite |
Tubulin beta chain |
| T3D0243 |
Sodium arsenite |
Poly [ADP-ribose] polymerase 1 |
| T3D0243 |
Sodium arsenite |
Kelch-like ECH-associated protein 1 |
| T3D0243 |
Sodium arsenite |
Glutathione reductase, mitochondrial |
| T3D0243 |
Sodium arsenite |
Glucocorticoid receptor |
| T3D0243 |
Sodium arsenite |
Estrogen receptor alpha |
| T3D0243 |
Sodium arsenite |
Haptoglobin |
| T3D0243 |
Sodium arsenite |
Hemoglobin subunit alpha |
| T3D0243 |
Sodium arsenite |
Hemoglobin subunit beta |
| T3D0243 |
Sodium arsenite |
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial |
| T3D0243 |
Sodium arsenite |
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial |
| T3D0243 |
Sodium arsenite |
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial |
| T3D0243 |
Sodium arsenite |
DNA repair protein complementing XP-A cells |
| T3D0243 |
Sodium arsenite |
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial |
| T3D0243 |
Sodium arsenite |
Actin, gamma-enteric smooth muscle |
| T3D0243 |
Sodium arsenite |
Actin, aortic smooth muscle |
| T3D0243 |
Sodium arsenite |
Actin, alpha skeletal muscle |
| T3D0243 |
Sodium arsenite |
Actin, alpha cardiac muscle 1 |