Calcium arsenate
描述
Calcium arsenate is a chemical compound or arsenic, made especially toxic by its high solubility in water. (L719)
类别
"Pesticide", "Pollutant", "Airborne Pollutant", "Synthetic Toxin"
同义词
"Calcium arsenic acid", "Calcium orthoarsenate", "Calcium-o-arsenate", "Chip-cal granular", "Cucumber dust", "Pencal", "Spra-cal", "Tricalcium arsenate"
IUPAC 名称
tricalcium diarsorate
传统名称
tricalcium diarsenate
简化分子线性输入规范
[Ca++].[Ca++].[Ca++].[O-][As]([O-])([O-])=O.[O-][As]([O-])([O-])=O
InChI 标识符
InChI=1S/2AsH3O4.3Ca/c2*2-1(3,4)5;;;/h2*(H3,2,3,4,5);;;/q;;3*+2/p-6
键
InChIKey=RMBBSOLAGVEUSI-UHFFFAOYSA-H
化合物类型
Inorganic compounds
大分类
Mixed metal/non-metal compounds
类型
Alkaline earth metal oxoanionic compounds
子类
Alkaline earth metal arsenates
直接大类
Alkaline earth metal arsenates
另外分类
"Inorganic arsenic compounds", "Inorganic calcium salts", "Inorganic oxides", "Metalloid salts", "Miscellaneous arsenates"
取代基
"Alkaline earth metal arsenate", "Arsenate", "Inorganic arsenic compound", "Inorganic calcium salt", "Inorganic metalloid salt", "Inorganic oxide", "Inorganic salt"
外部描述符
"Arsenical insecticides"
地位
Detected and Not Quantified
蜂窝位置
"Cytoplasm", "Extracellular"
暴露途径
Oral (L2) ; inhalation (L2) ; dermal (L2)
毒性机制
Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)
代谢
Arsenic is absorbed mainly by inhalation or ingestion, as to a lesser extent, dermal exposure. It is then distributed throughout the body, where it is reduced into arsenite if necessary, then methylated into monomethylarsenic (MMA) and dimethylarsenic acid (DMA) by arsenite methyltransferase. Arsenic and its metabolites are primarily excreted in the urine. Arsenic is known to induce the metal-binding protein metallothionein, which decreases the toxic effects of arsenic and other metals by binding them and making them biologically inactive, as well as acting as an antioxidant. (L20)
毒性值
LD50: 20 mg/kg (Oral, Rat) (T14)
LD50: 2400 mg/kg (Dermal, Rat) (T14)
致癌性
1, carcinogenic to humans. (L135)
用途/来源
Calcium arsenate is used as a pesticide. (L719)
最低风险等级
Acute Oral: 0.005 mg/kg/day (L134)
Chronic Oral: 0.0003 mg/kg/day (L134)
Chronic Inhalation: 0.01 mg/m3 (L134)
健康影响
Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, especially in skin, liver, bladder and lung cancers. (T1, L20)
症状
Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels.
治疗
Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)
创建于
2009-03-06 18:58:21 UTC
更新于
2014-12-24 20:21:24 UTC
目标
| 毒素T3DB ID | 毒素名称 | 目标名称 |
|---|
| T3D0241 |
Calcium arsenate |
Tubulin beta-8 chain-like protein LOC260334 |
| T3D0241 |
Calcium arsenate |
Tubulin beta-8 chain |
| T3D0241 |
Calcium arsenate |
Tubulin beta-6 chain |
| T3D0241 |
Calcium arsenate |
Tubulin beta-4A chain |
| T3D0241 |
Calcium arsenate |
Tubulin beta-3 chain |
| T3D0241 |
Calcium arsenate |
Tubulin beta-4B chain |
| T3D0241 |
Calcium arsenate |
Tubulin beta-2B chain |
| T3D0241 |
Calcium arsenate |
Tubulin beta-2A chain |
| T3D0241 |
Calcium arsenate |
Tubulin beta-1 chain |
| T3D0241 |
Calcium arsenate |
Tubulin alpha-8 chain |
| T3D0241 |
Calcium arsenate |
Tubulin alpha-4A chain |
| T3D0241 |
Calcium arsenate |
Tubulin alpha-3E chain |
| T3D0241 |
Calcium arsenate |
Tubulin alpha-3C/D chain |
| T3D0241 |
Calcium arsenate |
Tubulin alpha-1C chain |
| T3D0241 |
Calcium arsenate |
Tubulin alpha-1B chain |
| T3D0241 |
Calcium arsenate |
Tubulin alpha-1A chain |
| T3D0241 |
Calcium arsenate |
Tubulin alpha chain-like 3 |
| T3D0241 |
Calcium arsenate |
Pyruvate dehydrogenase protein X component, mitochondrial |
| T3D0241 |
Calcium arsenate |
Putative tubulin-like protein alpha-4B |
| T3D0241 |
Calcium arsenate |
Putative tubulin beta-4q chain |
| T3D0241 |
Calcium arsenate |
Putative tubulin beta chain-like protein ENSP00000290377 |
| T3D0241 |
Calcium arsenate |
Thioredoxin reductase 3 |
| T3D0241 |
Calcium arsenate |
Thioredoxin reductase 2, mitochondrial |
| T3D0241 |
Calcium arsenate |
Thioredoxin reductase 1, cytoplasmic |
| T3D0241 |
Calcium arsenate |
Actin, cytoplasmic 2 |
| T3D0241 |
Calcium arsenate |
Actin, cytoplasmic 1 |
| T3D0241 |
Calcium arsenate |
Tubulin beta chain |
| T3D0241 |
Calcium arsenate |
Poly [ADP-ribose] polymerase 1 |
| T3D0241 |
Calcium arsenate |
Kelch-like ECH-associated protein 1 |
| T3D0241 |
Calcium arsenate |
Glutathione reductase, mitochondrial |
| T3D0241 |
Calcium arsenate |
Glucocorticoid receptor |
| T3D0241 |
Calcium arsenate |
Estrogen receptor alpha |
| T3D0241 |
Calcium arsenate |
Haptoglobin |
| T3D0241 |
Calcium arsenate |
Hemoglobin subunit alpha |
| T3D0241 |
Calcium arsenate |
Hemoglobin subunit beta |
| T3D0241 |
Calcium arsenate |
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial |
| T3D0241 |
Calcium arsenate |
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial |
| T3D0241 |
Calcium arsenate |
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial |
| T3D0241 |
Calcium arsenate |
DNA repair protein complementing XP-A cells |
| T3D0241 |
Calcium arsenate |
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial |
| T3D0241 |
Calcium arsenate |
Actin, gamma-enteric smooth muscle |
| T3D0241 |
Calcium arsenate |
Actin, aortic smooth muscle |
| T3D0241 |
Calcium arsenate |
Actin, alpha skeletal muscle |
| T3D0241 |
Calcium arsenate |
Actin, alpha cardiac muscle 1 |