Actinium-227
SmallMolecule
T3DB_ID
T3D0230
描述
Actinium is a radioactive chemical element with the symbol Ac and atomic number 89. Actinium-227 is the naturally occurring radioactive isotope of actinium and has a half-life of 21.772 years. Actinium-227 is also produced in milligram amounts by the neutron irradiation of 226Ra in nuclear reactors. Actinium-227 is an alpha and beta emitter. It is extremely radioactive, and is even more dangerous than plutonium. Ingesting even small amounts would be fatal. (L1131)
类别
"Industrial/Workplace Toxin", "Pollutant", "Airborne Pollutant", "Natural Toxin"
同义词
"(227)Ac", "227Ac", "Actinium, isotope of mass 227", "Actinum 227"
CAS登记号
14952-40-0
化学式
Ac
平均分子量
227.0277
单同位素质量
227.027746979
IUPAC 名称
(²²⁷Ac)actinium
传统名称
(²²⁷Ac)actinium
简化分子线性输入规范
[227Ac]
InChI 标识符
InChI=1S/Ac/i1+0
InChIKey=QQINRWTZWGJFDB-IGMARMGPSA-N
化合物类型
Inorganic compounds
大分类
Homogeneous metal compounds
类型
Homogeneous actinide compounds
子类
直接大类
Homogeneous actinide compounds
另外分类
""
取代基
"Homogeneous actinide"
分子框架
外部描述符
""
地位
Detected and Not Quantified
起源
Exogenous
蜂窝位置
"Cytoplasm", "Extracellular"
生物流体位置
组织位置
途径
状态
Solid
外貌
Actinium is a silvery solid metal. Due to its intense radioactivity, actinium glows in the dark with a pale blue light. (L1131)
熔点/沸点/溶解度
1323°K (1050°C, 1922°F)/3471°K (3198 °C, 5788 °F)/
日志P
暴露途径
Oral (L1837) ; Inhalation (L1837)
毒性机制
The ionizing radiation produced by actinium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal change, and genetic instability. This leads to loss of normal cell and tissue homeostasis, and development of malignancy. Ionizing radiation that does not directly damage DNA can produce reactive oxygen intermediates that directly affect the stability of p53, an important enzyme in cell-cycle regulation, and produce oxidative damage to individual bases in DNA and point mutations by mispairing during DNA replication. (L1837)
代谢
毒性值
致死剂量
致癌性
Internalized radionuclides that emit α or β particles are carcinogenic to humans (Group 1) (L2150). Actinium-227 undergoes alpha and beta decay.
用途/来源
Actinium's radioactivity make it a valuable as a neutron source for energy. (L1131)
最低风险等级
健康影响
Actinium is extremely radioactive and thus poses a dangerous cancer risk. It can also cause acute radiation syndrome. (L1131)
症状
Exposure to high doses of ionizing radiation results in acute radiation syndrome, which can cause skin burns, hair loss, nausea, vomiting, dizziness, disorientation, low blood pressure, headache, fatigue, weakness, fever, birth defects, illness, infection, and death. (L1837, L1852)
治疗
Treatment reversing the effects of irradiation is currently not possible. Anaesthetics and antiemetics are administered to counter the symptoms of exposure, as well as antibiotics for countering secondary infections due to the resulting immune system deficiency. (L1852)
药库 ID
HMDB_ID
PubChem 化合物 ID
105152
维基百科链接
创建于
2009-03-06 18:58:20 UTC
更新于
2014-12-24 20:21:22 UTC
目标
毒素T3DB ID毒素名称目标名称
T3D0230 Actinium-227 DNA
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