Bis(2-methoxyethyl) phthalate
描述
Bis(2-methoxyethyl) phthalate (DMEP) is a specialty plasticiser, used in cellulose ester plastics, and can also be used as a solvent. This compound can form peroxides. (L1210)
类别
"Household Toxin", "Industrial/Workplace Toxin", "Synthetic Toxin"
同义词
"1,2-Benzenedicarboxylic acid, butyl methyl ester", "2-O-butyl 1-O-methyl benzene-1,2-dicarboxylate", "Bis(2-methoxyethyl) phthalic acid", "Butyl methyl phthalate", "Methyl butyl phthalate", "Phthalic acid, butyl methyl ester"
IUPAC 名称
1-butyl 2-methyl benzene-1,2-dicarboxylate
传统名称
1-butyl 2-methyl phthalate
简化分子线性输入规范
CCCCOC(=O)C1=CC=CC=C1C(=O)OC
InChI 标识符
InChI=1S/C13H16O4/c1-3-4-9-17-13(15)11-8-6-5-7-10(11)12(14)16-2/h5-8H,3-4,9H2,1-2H3
键
InChIKey=XXFSYINDUHLBIL-UHFFFAOYSA-N
类型
Benzene and substituted derivatives
子类
Benzoic acids and derivatives
另外分类
"Benzoyl derivatives", "Dicarboxylic acids and derivatives", "Hydrocarbon derivatives", "Methyl esters", "Organic oxides", "Organooxygen compounds"
取代基
"Aromatic homomonocyclic compound", "Benzoate ester", "Benzoyl", "Carboxylic acid derivative", "Carboxylic acid ester", "Dicarboxylic acid or derivatives", "Hydrocarbon derivative", "Methyl ester", "Organic oxide", "Organic oxygen compound", "Organooxygen compound"
分子框架
Aromatic homomonocyclic compounds
地位
Detected and Not Quantified
外貌
Light coloured, clear liquid, with a mild aromatic odour. (L1210)
熔点/沸点/溶解度
-40°C/340 °C/0.9 g/L (20°C)
暴露途径
Oral (L1903) ; inhalation (L1903) ; dermal (L1903)
毒性机制
Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expression. Some phthalates have also been shown to reduce the expression of insulin-like peptide 3 (insl3), an important hormone secreted by the Leydig cell necessary for development of the gubernacular ligament. Animal studies have shown that these effects disrupt reproductive development and can cause a number of malformations in affected young. (A2883)
代谢
In pregnant rat, DMEP rapidly undergoes hydrolysis to 2-methoxyethanol (2-ME) and mono-2-methoxyethyl phthalate (MMEP). 2-ME is then oxidised to methoxyacetic acid (MAA). The rat foetus has little or no ability to hydrolyse DMEP to the monoester and intact DMEP is rapidly transferred across the placenta into the foetus. (L1210)
致癌性
No indication of carcinogenicity to humans (not listed by IARC).
用途/来源
Bis(2-methoxyethyl) phthalate (DMEP) is a specialty plasticizer, used in cellulose ester plastics, and can also be used as a solvent. (L1210)
健康影响
Phthalate esters are endocrine disruptors. Animal studies have shown that they disrupt reproductive development and can cause a number of malformations in affected young, such as reduced anogenital distance (AGD), cryptorchidism, hypospadias, and reduced fertility. The combination of effects associated with phthalates is called 'phthalate syndrome’. (A2883)
症状
Phthalate esters are endocrine disruptors and can cause a number of developmental malformations termed 'phthalate syndrome'. (A2883)
创建于
2009-03-06 18:58:15 UTC
更新于
2014-12-24 20:21:18 UTC