1,2-Diphenylhydrazine
描述
1,2-Diphenylhydrazine is a white solid. It dissolves only slightly in water and does not change into a gas unless it is heated to very high temperatures. It sticks to soil and can be carried into the air along with windblown dust. Once in water or exposed to air it is changed into other chemicals within minutes. These chemicals include the toxic chemicals azobenzene and benzidine. 1,2-Diphenylhydrazine is used to make fabric dyes in other countries, and to make certain medicines. (L463)
类别
"Industrial/Workplace Toxin", "Pollutant", "Airborne Pollutant", "Synthetic Toxin"
同义词
"1, 2-Diphenylhydrazine", "1,1'-Hydrazodibenzene", "1,2-Diphenyldrazine", "Diphenylhydrazine", "Hydrazobenzene", "Hydrazodibenzene", "N, N'-bianiline", "N,N'-bianiline", "N,N'-diphenylhydrazine", "SYM-diphenylhydrazine", "Symmetrical diphenyl hydrazine"
IUPAC 名称
1,2-diphenylhydrazine
简化分子线性输入规范
N(NC1=CC=CC=C1)C1=CC=CC=C1
InChI 标识符
InChI=1S/C12H12N2/c1-3-7-11(8-4-1)13-14-12-9-5-2-6-10-12/h1-10,13-14H
键
InChIKey=YBQZXXMEJHZYMB-UHFFFAOYSA-N
类型
Benzene and substituted derivatives
另外分类
"Hydrazines and derivatives", "Hydrocarbon derivatives", "Organopnictogen compounds"
取代基
"Aromatic homomonocyclic compound", "Hydrazine derivative", "Hydrocarbon derivative", "Organic nitrogen compound", "Organonitrogen compound", "Organopnictogen compound", "Phenylhydrazine"
分子框架
Aromatic homomonocyclic compounds
地位
Detected and Not Quantified
熔点/沸点/溶解度
131°C//0.221 mg/mL at 25 °C [KUHNE,R et al. (1995)]
毒性机制
Two of the known metabolites, aniline and benzidine, may contribute to the toxicity and/or carcinogenicity of 1,2-diphenylhydrazine. Nonneoplastic liver lesions, hepatocellular carcinomas and/or neoplastic liver nodules indicate that the liver is a target of 1,2-diphenylhydrazine toxicity. As aniline and other aromatic amino metabolites of 1,2-diphenylhydrazine (e.g., aminophenols) are methemoglobinforming compounds by either oral or inhalation routes of exposure, it is possible that 1,2-diphenylhydrazine may cause methemoglobinemia in humans. (L463)
代谢
Unchanged 1,2-diphenylhydrazine was detected following treatment by all routes, and aniline and benzidine were identified following oral and intraperitoneal treatments. Other metabolites included two unspecified hydroxy derivatives of benzidine (oral route), 2- and 4- aminophenol (intraperitoneal route), and unidentified compounds (oral, intravenous, and intratracheal routes). Aniline is oxidized by hydroxylation of a ring carbon to form 2-or 4-aminophenol or of the nitrogen to form phenylhydroxylamine, and then is conjugated to glucuronic or sulfuric acid. Benzidine is formed readily from 1,2-diphenylhydrazine by acid rearrangement. It has been suggested that benzidine may be produced from 1,2-diphenylhydrazine by acidity in the stomach. (L463)
毒性值
LD50: 959 mg/kg (Oral, Rat) (L463)
致癌性
Not listed by IARC. Benzidine, a metabolite of 1,2-diphenylhydrazine, is carcinogenic to humans (Group 1). Aniline, another metabolite, is not classifiable as to its carcinogenicity to humans (Group 3). (L135)
用途/来源
1,2-Diphenylhydrazine is used to make fabric dyes in other countries, and to make certain medicines. Exposure may result from breathing in dust coated with 1,2-diphenylhydrazine and eating dirt or smearing contaminated dirt on the skin. (L463)
健康影响
Nonneoplastic liver lesions, hepatocellular carcinomas and/or neoplastic liver nodules; seizures and coma. (L463)
症状
Irritatinon to the eyes, nose and respiratory system, depending on the route of exposure. Cough, redness of the exposed surface. (L463)
治疗
Consider gastric lavage after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion. Following inhalation, move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids. Irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. If the exposure occurs through dermal contact remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists. (T36)
创建于
2009-03-06 18:58:12 UTC
更新于
2014-12-24 20:21:15 UTC