同义词
"1,1-Bis(4-chlorophenyl)-2,2,2-trichloroethanol", "1,1-Bis(chlorophenyl)-2,2,2-trichloroethanol", "1,1-Bis(p-Chlorophenyl)-2,2,2-trichloroethanol", "1,1-bis-(chlorophenyl)-2,2,2-trichloroethanol", "1,1-Bis-(p-chlorophenyl)-2,2,2-trichloroethanol", "2,2,2-Trichloro-1,1-bis(4-chlorophenyl)ethanol", "2,2,2-Trichloro-1,1-bis(p-chlorophenyl)ethanol", "2,2,2-Trichloro-1,1-di(4-chlorophenyl)ethanol", "2,2,2-Trichloro-1,1-di-(4-chlorophenyl)ethanol", "4,4'-Dichloro-.alpha.-(trichloromethyl)benzhydrol", "4,4'-Dichloro-a-(trichloromethyl)benzhydrol", "4,4'-Dichloro-alpha-(trichloromethyl)benzhydrol", "4-chloro-alpha-(4-Chlorophenyl)-alpha-(trichloromethyl)benzenemethanol", "Acarin", "Bis(chlorophenyl)-2,2,2-trichl oroethanol", "Bis(chlorophenyl)-2,2,2-trichloroethanol", "Carbax", "Carbox", "Cekudifol", "Decofol", "Di-(p-chlorophenyl)trichloromethylcarbinol", "Dichlorokelthane", "Dicomite", "DTMC", "Fumite dicofol", "Hifol", "Hilfol", "Keltane", "Kelthane", "Kelthane a", "Kelthane dust base", "Kelthanethanol", "Kelthone", "Mifol", "Milbol", "Mitigan", "p,p'-di cofol", "p,p'-dicofol", "p,p'-kelthane", "p,p-dicofol", "Para,para'-kelthane", "Tricofol"
取代基
"Alcohol", "Alkyl chloride", "Alkyl halide", "Aromatic alcohol", "Aromatic homomonocyclic compound", "Aryl chloride", "Aryl halide", "Chlorobenzene", "Chlorohydrin", "Diphenylmethane", "Halobenzene", "Halohydrin", "Hydrocarbon derivative", "Organic oxygen compound", "Organochloride", "Organohalogen compound", "Organooxygen compound", "Tertiary alcohol"
毒性机制
Like other organochloride pesticides, dicofol is believed to act by at least four mechanisms, possibly all functioning simultaneously. It may reduce potassium transport across the membrane. Dicofol also alters the porous channels through which sodium ions pass. These channels activate (open) normally but are inactivated (closed) slowly, thus interfering with the active transport of sodium out of the nerve axon during repolarization. Dicofol inhibits neuronal adenosine triphosphatases (ATPases), particularly Na+K+-ATPase, and Ca2+-ATPase which play vital roles in neuronal repolarization. Dicofol also inhibits the ability of calmodulin, a calcium mediator in nerves, to transport calcium ions that are essential for the release of neurotransmitters. All these inhibited functions reduce the rate of depolarization and increase the sensitivity of neurons to small stimuli that would not elicit a response in a fully depolarized neuron. Difocol is also an endocrine disruptor and binds both the androgen and estrogen receptor. In addition, it may alter sex hormone metabolism by directly inhibiting cytochrome P-450 19A1. Difocol is able to competitively bind transthyretin, which lowers plasma thyroid hormone levels. (T10, A214, A228, A229)
代谢
Dicofol can be absorbed via oral, inhahation, and dermal routes. It is distributed primarily to the adipose tissue, as well as the adrenal glands, thyroid, and liver. Metabolism of dicofol produces the metabolites 4,4'-dichloro-benzophenone and 4,4'-dichlorodicofol. Dicofol and its metabolites are excreted mainly in the faeces. (L631, L632)