Strontium-90
SmallMolecule
T3DB_ID
T3D0120
描述
Strontium is a naturally occurring element found in rocks, soil, dust, coal, and oil. Strontium-90 is a radioactive isotope of strontium (Sr) with a half-life of 28.8 years. Strontium-90 is a product of nuclear fission and is obtained during nuclear reprocessing of spent nuclear fuel and is a beta-emitter. Strontium 90 is extensively used in medicine and industry. Strontium-90 is a radioactivity hazard and is linked to cancers. (L1135, L1839)
类别
"Industrial/Workplace Toxin", "Pollutant", "Airborne Pollutant", "Natural Toxin"
同义词
"(99)Sr", "99Sr", "Sr-90", "Strontium 90", "Strontium, isotope of mass 90"
CAS登记号
10098-97-2
化学式
Sr
平均分子量
89.9077
单同位素质量
89.907737596
IUPAC 名称
(⁹⁰Sr)strontium
传统名称
(⁹⁰Sr)strontium
简化分子线性输入规范
[90Sr]
InChI 标识符
InChI=1S/Sr/i1+2
InChIKey=CIOAGBVUUVVLOB-NJFSPNSNSA-N
化合物类型
大分类
类型
子类
直接大类
另外分类
取代基
分子框架
外部描述符
地位
Detected and Not Quantified
起源
Exogenous
蜂窝位置
"Cytoplasm", "Extracellular"
生物流体位置
组织位置
途径
状态
外貌
熔点/沸点/溶解度
//
日志P
暴露途径
Oral (L1135)
毒性机制
The fact that strontium is chemically similar to calcium allows it to exchange for calcium in bone. It affects bone development and strength by binding directly to hydroxyapatite crystals, which interferes with the normal crystalline structure of bone. Strontium can also interact with secondary cell messenger systems and transporter systems that normally use calcium. It is thought to bind to the calcium receptor of the parathyroid gland, thereby suppressing parathyroid hormone levels, preventing vitamin D3 activiation, and reducing calcium absorption. The ionizing radiation produced by strontium-90 causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal change, and genetic instability. This leads to loss of normal cell and tissue homeostasis, and development of malignancy. Strontium's ability to mimick calcium makes bone cancer a particular risk. Ionizing radiation that does not directly damage DNA can produce reactive oxygen intermediates that directly affect the stability of p53, an important enzyme in cell-cycle regulation, and produce oxidative damage to individual bases in DNA and point mutations by mispairing during DNA replication. (L1837, L1839)
代谢
The radioactivity of strontium-90 allow it to penetrate the body following inhalation, ingestion, or dermal exposure. Strontium-90 exhibits biochemical behavior similar to calcium. After entering the organism, about 70-80% of the dose is excreted. Virtually all remaining strontium-90 is deposited in bones and bone marrow, with the remaining 1% remaining in blood and soft tissues. The metabolism of strontium consists of binding interactions with proteins and, based on its similarity to calcium, probably complex formation with various inorganic anions such as carbonate and phosphate, and carboxylic acids such as citrate and lactate. Strontium-90 is eliminated mainly in the urine and faeces. (L1135)
毒性值
致死剂量
致癌性
1, carcinogenic to humans. (L135)
用途/来源
Strontium-90 is widely used in medicine and industry, as a radioactive source for thickness gauges, and for superficial radiotherapy of some cancers. Being cheaper than the alternative 238Pu, it is used as a heat source in many Russian and Soviet radioisotope thermoelectric generators. It is also used as a radioactive tracer in medicine and agriculture. (L1135)
最低风险等级
Intermediate Oral: 2 mg/kg/day (L134)
健康影响
High levels of radioactive strontium can damage bone marrow, cause anemia and prevent the blood from clotting properly. Strontium-90 present in bones could cause bone cancer, cancer of nearby tissues, and leukemia. (L1135, L1839)
症状
High levels of radioactive strontium can damage bone marrow, cause anemia and prevent the blood from clotting properly. Exposure to high doses of ionizing radiation results in acute radiation syndrome, which can cause skin burns, hair loss, nausea, vomiting, dizziness, disorientation, low blood pressure, headache, fatigue, weakness, fever, birth defects, illness, infection, and death. (L1837, L1852, L1839)
治疗
Treatment reversing the effects of irradiation is currently not possible. Anaesthetics and antiemetics are administered to counter the symptoms of exposure, as well as antibiotics for countering secondary infections due to the resulting immune system deficiency. (L1852)
药库 ID
HMDB_ID
PubChem 化合物 ID
5486204
维基百科链接
http://en.wikipedia.org/wiki/Strontium-90
创建于
2009-03-06 18:58:07 UTC
更新于
2014-12-24 20:21:09 UTC
目标
毒素T3DB ID毒素名称目标名称
T3D0120 Strontium-90 DNA
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