1,2,3-Trichlorobenzene
描述
1,2,3-Trichlorobenzene is an organochloride aromatic compound and one of the three isomeric forms of trichlorobenzene. Trichlorobenzene is used as a solvent. (L223)
类别
"Pesticide", "Industrial/Workplace Toxin", "Synthetic Toxin"
同义词
"1,2, 3-Trichlorobenzene", "1,2,3-Trichlorbenzol", "1,2,6-Trichlorobenzene", "Trichlorbenzene", "Vic-trichlorobenzene"
IUPAC 名称
1,2,3-trichlorobenzene
传统名称
1,2,3-trichlorobenzene
简化分子线性输入规范
ClC1=CC=CC(Cl)=C1Cl
InChI 标识符
InChI=1S/C6H3Cl3/c7-4-2-1-3-5(8)6(4)9/h1-3H
键
InChIKey=RELMFMZEBKVZJC-UHFFFAOYSA-N
类型
Benzene and substituted derivatives
另外分类
"Aryl chlorides", "Hydrocarbon derivatives", "Organochlorides"
取代基
"Aromatic homomonocyclic compound", "Aryl chloride", "Aryl halide", "Chlorobenzene", "Hydrocarbon derivative", "Organochloride", "Organohalogen compound"
分子框架
Aromatic homomonocyclic compounds
外部描述符
"a small molecule", "trichlorobenzene"
地位
Detected and Not Quantified
蜂窝位置
"Membrane", "Membrane Fraction"
熔点/沸点/溶解度
53.5°C//0.018 mg/mL at 25 °C [CHIOU,CT et al. (1986)]
暴露途径
Oral (T38) ; inhalation (T38) ; dermal (T38)
毒性机制
Trichlorobenzene may uncouple mitochondrial oxidative phosphorylation, inducing potassium ion release and inhibiting respiratory control. It's metabolites may covalently bind to cellular proteins and alkylate DNA. (A154, A155)
代谢
Trichlorobenzene is absorbed via oral, inhalation, and dermal routes. It is believed to be metabolized via cytochrome p-450 enzymes into metabolites that include phenols, mercapturic acid, and catechols.(T38)
毒性值
LD50: 756 mg/kg (Oral, Rat) (T20)
致癌性
No indication of carcinogenicity to humans (not listed by IARC).
用途/来源
Trichlorobenzene is used as a solvent in chemical manufacturing, as well as in dyes, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium, and insecticides. (T39)
健康影响
High levels of trichlorobenzene may damage the liver, kidney, and thyroid. (A153)
症状
Trichlorobenzene irritates the eyes and respiratory tract. (T20)
创建于
2009-03-06 18:58:06 UTC
更新于
2014-12-24 20:21:08 UTC
目标
| 毒素T3DB ID | 毒素名称 | 目标名称 |
|---|
| T3D0116 |
1,2,3-Trichlorobenzene |
Estrogen receptor beta |
| T3D0116 |
1,2,3-Trichlorobenzene |
Estrogen receptor alpha |
| T3D0116 |
1,2,3-Trichlorobenzene |
Sodium/potassium-transporting ATPase subunit beta-3 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Sodium/potassium-transporting ATPase subunit beta-2 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Sodium/potassium-transporting ATPase subunit beta-1 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Sodium/potassium-transporting ATPase subunit alpha-4 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Sodium/potassium-transporting ATPase subunit alpha-3 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Sodium/potassium-transporting ATPase subunit alpha-2 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Sodium/potassium-transporting ATPase subunit alpha-1 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Sodium/potassium-transporting ATPase subunit gamma |
| T3D0116 |
1,2,3-Trichlorobenzene |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Plasma membrane calcium-transporting ATPase 4 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Plasma membrane calcium-transporting ATPase 3 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Plasma membrane calcium-transporting ATPase 2 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Plasma membrane calcium-transporting ATPase 1 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit theta |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit rho-3 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit rho-2 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit rho-1 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit pi |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit gamma-3 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit gamma-2 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit gamma-1 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit epsilon |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit delta |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit beta-3 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit beta-2 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit beta-1 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit alpha-6 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit alpha-5 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit alpha-4 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit alpha-3 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit alpha-2 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Gamma-aminobutyric acid receptor subunit alpha-1 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Calcium-transporting ATPase type 2C member 2 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Calcium-transporting ATPase type 2C member 1 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Transient receptor potential cation channel subfamily A member 1 |
| T3D0116 |
1,2,3-Trichlorobenzene |
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
| T3D0116 |
1,2,3-Trichlorobenzene |
72 kDa type IV collagenase |
| T3D0116 |
1,2,3-Trichlorobenzene |
Retinoic acid receptor gamma-2 |