alpha-Hexachlorocyclohexane
SmallMolecule
T3DB_ID
T3D0115
描述
Hexachlorocyclohexane, Alpha- is one of eight isoforms of the commercially manufactured chemical hexachlorocyclohexane. It is used as an insecticide on fruit, vegetables, and forest crops and is also available as a prescription (lotion, cream, or shampoo) to treat head and body lice, and scabies. (L108)
类别
"Pesticide", "Pollutant", "Airborne Pollutant", "Synthetic Toxin"
同义词
"(1R,2R,3R,4R,5S,6S)-1,2,3,4,5,6-hexachlorocyclohexane", "1alpha,2alpha,3beta,4alpha,5beta,6beta-Hexachlorocyclohexane", "a-1,2,3,4,5,6-Hexachlorcyclohexane", "a-1,2,3,4,5,6-Hexachlorocyclohexane", "a-benzene hexachloride", "a-hexachloran", "a-hexachlorane", "a-hexachlorcyclohexane", "a-Hexachlorocyclohexane", "a-hexachlorocyclohexane", "alpha-1,2,3,4,5,6-Hexachlorocyclohexane", "Alpha-benzene hexachloride", "Alpha-benzenehexachloride", "alpha-HCH", "Alpha-hexachloran", "Alpha-hexachlorane", "Alpha-hexachlorocyclohexane", "Alpha-hexachlorocyclohexanes", "Alpha-lindane", "Am eisenatod", "Ameisenatod", "Ameisentod", "Aparasin", "Aphtiria", "Aphtitria", "Aplidal", "Arbitex", "Arcotal S", "Benhexachlor", "Benhexol", "Benzanex", "Benzene hexachloride", "Benzene hexachloride, all isomers", "Benzene hexachloride-a-isomer", "Benzene hexachloride-alpha-isomer", "Benzene hexachloride-gamma isomer", "Benzene hexachloride-gamma-isomer", "Benzene-1,2,3,4,5,6-hexachloride ((Ambiguous)", "Benzene-cis-hexachloride", "Benzene-trans-hexachloride", "Benzenehexachloride, mixed isomers", "Benzenehexachloride-alpha-isomer", "Benzex", "beta-1,2,3,4,5,6-Hexachlorocyclohexane", "Beta-benzene hexachloride", "Beta-hexac hlorocyclohexane", "Beta-hexachloran", "Beta-hexachlorobenzene", "Beta-hexachlorocyclohexane", "Beta-hexachlorocyclohexanes", "Beta-isomer", "Beta-lindane", "Bexol", "Celanex", "Chloresene", "Codechine", "Cyclohexane, 1,2,3,4,5,6-hexachloro-, a-isomer", "Delitex", "delta-1,2,3,4,5,6-Hexachlorocyclohexane", "Delta-benzene hexachloride", "Delta-benzenehexachloride", "Delta-hexachlorocyclohexane", "Delta-lindane", "Detmol extract", "Devoran", "Entomoxan", "Epsilon HCH", "Epsilon-benzenehexachloride", "Epsilon-HCH", "Epsilon-hexachlorocyclohexane", "Eso derm", "Esoderm", "Exagama", "Forlin", "Forst-nexen", "Gallogama", "Gamacarbatox", "Gamaphex", "Gamene", "Gamiso", "Gamma benzene hexachloride", "Gamma hexachlor", "Gamma hexachlorocyclohexane", "gamma-1,2,3,4,5,6-Hexachlorocyclohexane", "Gamma-benzene hexachloride", "Gamma-benzenehexachloride", "Gamma-benzohexachloride", "Gamma-hexachlorane", "Gamma-hexachlorobenzene", "Gamma-hexachlorocyclohexane", "Gamma-linda ne", "Gamma-lindane", "Gammahexa", "Gammahexane", "Gammalin", "Gammaterr", "Gammex", "Gammexane", "Gammopaz", "Gamtox", "Geobilan", "Gexane", "Gyben", "Heclotox", "Hecoltox", "Hexablanc", "Hexachlor", "Hexachloran", "Hexachlorane", "Hexachloride, benzene", "Hexachloride, gamma-benzene", "Hexachlorocyclohexane", "Hexachlorocyclohexane, gamma isomer", "Hexachlorocyclohexane, gamma-isomer", "Hexachlorocyclohexane-alpha", "Hexachlorocyclohexane-beta", "Hexachlorocyclohexanes", "Hexachlorzyklohexan", "Hexamul", "Hexapoudre", "Hexatox", "Hexaverm", "Hexcidum", "Hexicide", "Hexyclan", "Hilbeec h", "Hilbeech", "Hortex", "Inexit", "Insecticide, BHC", "Isatox", "Isot ox", "Isotox", "Jacutin", "Kokotine", "Kwell", "Kwell-r", "Lasochron", "Lendine", "Lentox", "Lidenal", "Lindafor", "Lindagam", "Lindagrain", "Lindagranox", "Lindalo", "Lindam ul", "Lindamul", "Lindaterra", "Lindatox", "Lindex", "Lindosep", "Lintox", "Linvur", "Lorexane", "Mglawik l", "Mszycol", "Neo-scabicidol", "Nexen FB", "Nexen-FB", "Nexi t-stark", "Nexit", "Nexit-stark", "Nexol-e", "Nicochloran", "Novigam", "Novigan", "Omnitox", "Ovadziak", "Owadziak", "Pedraczak", "Pflanzol", "PMS lindane", "PMS-lindane", "Scabecid", "Scabene", "Scabisan", "Silvanol", "Tetocid", "Viton", "α-Hexachlorocyclohexane"
CAS登记号
319-84-6
化学式
C6H6Cl6
平均分子量
290.83
单同位素质量
287.860066434
IUPAC 名称
(1R,2R,3R,4R,5S,6S)-1,2,3,4,5,6-hexachlorocyclohexane
传统名称
α-hexachlorocyclohexane
简化分子线性输入规范
Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H](Cl)[C@H]1Cl
InChI 标识符
InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4-,5+,6+/m1/s1
InChIKey=JLYXXMFPNIAWKQ-SHFUYGGZSA-N
化合物类型
Organic compounds
大分类
Organohalogen compounds
类型
Alkyl halides
子类
Cyclohexyl halides
直接大类
Cyclohexyl halides
另外分类
"Alkyl chlorides", "Hydrocarbon derivatives", "Organochlorides"
取代基
"Aliphatic homomonocyclic compound", "Alkyl chloride", "Cyclohexyl halide", "Hydrocarbon derivative", "Organochloride"
分子框架
Aliphatic homomonocyclic compounds
外部描述符
"hexachlorocyclohexane"
地位
Detected and Not Quantified
起源
Exogenous
蜂窝位置
"Cytosol", "Membrane", "Microsome", "Mitochondrion", "Plasma Membrane"
生物流体位置
组织位置
途径
"Pyrimidine Metabolism", "Dna replication", "Apoptosis", "Ddt Degradation", "Abc transporters", "Cell cycle", "Arachidonic Acid Metabolism"
状态
Solid
外貌
White powder or colorless vapor.
熔点/沸点/溶解度
159.5°C//0.002 mg/mL at 25 °C [WEIL,L et al. (1974)]
日志P
暴露途径
Oral (L108) ; inhalation (L108) ; dermal (L108)
毒性机制
Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picrotoxin binding site, causing over stimulation of the central nervous system. It is also believed to inhibit sodium/potassium-transporting ATPases and to be an endocrine disruptor. In the liver, hexachlorocyclohexane is thought to cause oxidative stress by interfering with hepatic oxidative capacity and glutathione metabolism, increasing lipid metabolism, and inhibiting magnesium ATPase activity. Hexachlorocyclohexane may also inhibit gap junction and intercellular communication, leading to uncontrolled cell growth and tumor promotion. (L108, L109, A60)
代谢
Hexachlorocyclohexane is absorbed through the skin, lungs, and intestines, then distributed mainly to the adipose tissue but also to the brain, kidney, muscle, and blood. Metabolism occurs via dechlorination, dehydrogenation, dehydrochlorination, and hydroxylation by hepatic cytochrome P-450 enzymes. The main metabolites are polychlorophenols and 1,2,4-trichlorocyclohexane-4,5-epoxide, which are excreted in the urine. (L108)
毒性值
LD50: 177 mg/kg (Oral, Rat) (T13)
致死剂量
致癌性
2B, possibly carcinogenic to humans. (L135)
用途/来源
Hexachlorocyclohexane is used as an insecticide on fruit, vegetables, and forest crops and is also available as a prescription (lotion, cream, or shampoo) to treat head and body lice, and scabies. (L108)
最低风险等级
Chronic Oral: 0.008 mg/kg/day (L134)
健康影响
Exposure to large amounts of hexachlorocyclohexane can harm the nervous system, producing a range of symptoms from headache and dizziness to seizures, convulsions and more rarely death. Hexachlorocyclohexane is known to damage the liver, kidneys, and immune system, as well as cause blood disorders and reproductive and developmental defects. Hexachlorocyclohexane is also potentially carcinogenic. (L108, L109)
症状
Exposure to large amounts of hexachlorocyclohexane can harm the nervous system, producing a range of symptoms from headache and dizziness to seizures, convulsions and more rarely death. (L109)
治疗
Hexachlorocyclohexane poisoning is treated symptomatically. Gastric lavage, followed by the administration of activated charcoal, may be performed upon ingestion. (L148)
药库 ID
HMDB_ID
PubChem 化合物 ID
727
维基百科链接
http://en.wikipedia.org/wiki/Lindane
创建于
2009-03-06 18:58:06 UTC
更新于
2014-12-24 20:21:08 UTC
目标
毒素T3DB ID毒素名称目标名称
T3D0115 alpha-Hexachlorocyclohexane Estrogen receptor beta
T3D0115 alpha-Hexachlorocyclohexane Estrogen receptor alpha
T3D0115 alpha-Hexachlorocyclohexane Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
T3D0115 alpha-Hexachlorocyclohexane Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
T3D0115 alpha-Hexachlorocyclohexane Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
T3D0115 alpha-Hexachlorocyclohexane Plasma membrane calcium-transporting ATPase 4
T3D0115 alpha-Hexachlorocyclohexane Plasma membrane calcium-transporting ATPase 3
T3D0115 alpha-Hexachlorocyclohexane Plasma membrane calcium-transporting ATPase 2
T3D0115 alpha-Hexachlorocyclohexane Plasma membrane calcium-transporting ATPase 1
T3D0115 alpha-Hexachlorocyclohexane Calcium-transporting ATPase type 2C member 2
T3D0115 alpha-Hexachlorocyclohexane Calcium-transporting ATPase type 2C member 1
T3D0115 alpha-Hexachlorocyclohexane Nuclear receptor subfamily 1 group I member 2
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit epsilon
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit theta
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit rho-3
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit gamma-1
T3D0115 alpha-Hexachlorocyclohexane Progesterone receptor
T3D0115 alpha-Hexachlorocyclohexane Androgen receptor
T3D0115 alpha-Hexachlorocyclohexane Estrogen-related receptor gamma
T3D0115 alpha-Hexachlorocyclohexane Sodium/potassium-transporting ATPase subunit gamma
T3D0115 alpha-Hexachlorocyclohexane Sodium/potassium-transporting ATPase subunit beta-3
T3D0115 alpha-Hexachlorocyclohexane Sodium/potassium-transporting ATPase subunit beta-2
T3D0115 alpha-Hexachlorocyclohexane Sodium/potassium-transporting ATPase subunit beta-1
T3D0115 alpha-Hexachlorocyclohexane Sodium/potassium-transporting ATPase subunit alpha-4
T3D0115 alpha-Hexachlorocyclohexane Sodium/potassium-transporting ATPase subunit alpha-3
T3D0115 alpha-Hexachlorocyclohexane Sodium/potassium-transporting ATPase subunit alpha-2
T3D0115 alpha-Hexachlorocyclohexane Sodium/potassium-transporting ATPase subunit alpha-1
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit rho-2
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit rho-1
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit pi
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit gamma-3
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit gamma-2
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit delta
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit beta-3
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit beta-2
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit beta-1
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit alpha-6
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit alpha-5
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit alpha-4
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit alpha-3
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit alpha-2
T3D0115 alpha-Hexachlorocyclohexane Gamma-aminobutyric acid receptor subunit alpha-1
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