同义词

3.1.3.48; HD-PTP; His domain-containing protein tyrosine phosphatase; KIAA1471; Protein tyrosine phosphatase TD14; PTP-TD14

UniProt ID

Q9H3S7

UniProt名字

PTN23_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

PTPN23

生物

Human

氨基酸序列

>lcl|BSEQ0009000|Tyrosine-protein phosphatase non-receptor type 23 MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPR DFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYN LGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNL MLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKL VQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRF TMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKL VPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLDAYSHIPPQ LMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQA GAISITSKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAAL PTPALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKK LFEEQLKKYDQLKVYLEQNLAAQDRVLCALTEANVQYAAVRRVLSDLDQKWNSTLQTLVA SYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAREAARQQLLDRELKKKPPPRP TAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSST GPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQ HGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPN PTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQ PHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYP GPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTP SPHLVPSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPL LQPTKVDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAFRGQLGDVGALDTVWRELQD AQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLV ATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLAL SSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLH QRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKL HLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQA TIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKE EPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHNGQGLRATRPS DDPLSLLDPLWTLNKT

目标基因序列

残基数

1636

分子量

178971.945

理论 pI

一般功能

Protein tyrosine phosphatase activity

具体功能

Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.

跨膜区

GenBank 蛋白质 ID

目标蛋白质序列

基因序列

>lcl|BSEQ0013557|Tyrosine-protein phosphatase non-receptor type 23 (PTPN23) ATGCTGGGGGCCATGGACAAGCGGGTGTCTGAGGAGGGCATGAAGGTCTCCTGTACCCAT TTCCAGTGCGCAGCCGGCGCCTTCGCCTACCTACGGGAGCACTTCCCTCAAGCCTACAGC GTCGACATGAGCCGCCAGATCCTTACGCTCAACGTCAACCTCATGCTGGGCCAGGCTCAG GAGTGCCTCCTGGAGAAGTCGATGTTGGACAACAGGAAGAGCTTTCTGGTGGCCCGCATC AGTGCACAGGTGGTAGATTACTACAAGGAGGCATGCCGGGCCTTGGAGAACCCCGACACT GCCTCACTGCTGGGCCGGATCCAGAAGGACTGGAAGAAACTTGTGCAGATGAAGATCTAC TACTTCGCAGCCGTGGCTCATCTGCACATGGGAAAGCAGGCCGAGGAGCAGCAGAAGTTC GGGGAGCGGGTTGCATACTTCCAGAGCGCCCTGGACAAGCTCAATGAAGCCATCAAGTTG GCCAAGGGCCAGCCTGACACTGTGCAAGACGCGCTTCGCTTCACTATGGATGTCATTGGG GGAAAGTACAATTCTGCCAAGAAGGACAACGACTTCATTTACCATGAGGCTGTCCCAGCA TTGGACACTCTTCAGCCTGTAAAAGGAGCCCCCTTGGTGAAGCCCTTGCCAGTGAACCCC ACAGACCCAGCTGTTACAGGCCCTGACATCTTTGCCAAACTGGTACCCATGGCTGCCCAC GAGGCCTCGTCACTGTACAGTGAGGAGAAGGCCAAGCTGCTCCGGGAGATGATGGCCAAG ATTGAGGACAAGAATGAGGTCCTGGACCAGTTCATGGATTCAATGCAGTTGGATCCCGAG ACGGTGGACAACCTTGATGCCTACAGCCACATCCCACCCCAGCTCATGGAGAAGTGCGCG GCTCTCAGCGTCCGGCCCGACACTGTCAGGAACCTTGTACAGTCCATGCAAGTGCTGTCA GGTGTGTTCACGGATGTGGAGGCTTCCCTGAAGGACATCAGAGATCTGTTGGAGGAGGAT GAGCTGCTAGAGCAGAAGTTTCAGGAGGCGGTGGGCCAGGCAGGGGCCATCTCCATCACC TCCAAGGCTGAGCTGGCAGAGGTGAGGCGAGAATGGGCCAAGTACATGGAAGTCCATGAG AAGGCCTCCTTCACCAACAGTGAGCTGCACCGTGCCATGAACCTGCACGTCGGCAACCTG CGCCTGCTCAGCGGGCCGCTTGACCAGGTCCGGGCTGCCCTGCCCACACCGGCCCTCTCC CCAGAGGACAAGGCCGTGCTGCAAAACCTAAAGCGCATCCTGGCTAAGGTGCAGGAGATG CGGGACCAGCGCGTGTCCCTGGAGCAGCAGCTGCGTGAGCTTATCCAGAAAGATGACATC ACTGCCTCGCTGGTCACCACAGACCACTCAGAGATGAAGAAGTTGTTCGAGGAGCAGCTG AAAAAGTATGACCAGCTGAAGGTGTACCTGGAGCAGAACCTGGCCGCCCAGGACCGTGTC CTCTGTGCACTGACAGAGGCCAACGTGCAGTACGCAGCCGTGCGGCGGGTACTCAGCGAC TTGGACCAAAAGTGGAACTCCACGCTGCAGACCCTGGTGGCCTCGTATGAAGCCTATGAG GACCTGATGAAGAAGTCGCAGGAGGGCAGGGACTTCTACGCAGATCTGGAGAGCAAGGTG GCTGCTCTGCTGGAGCGCACGCAGTCCACCTGCCAGGCCCGCGAGGCTGCCCGCCAGCAG CTCCTGGACAGGGAGCTGAAGAAGAAGCCGCCGCCACGGCCCACAGCCCCAAAGCCGCTG CTGCCCCGCAGGGAGGAGAGTGAGGCAGTGGAAGCAGGAGACCCCCCTGAGGAGCTGCGC AGCCTCCCCCCTGACATGGTGGCTGGCCCACGACTGCCTGACACCTTCCTGGGAAGTGCC ACCCCGCTCCACTTTCCTCCCAGCCCCTTCCCCAGCTCCACAGGCCCAGGACCCCACTAT CTCTCAGGCCCCTTGCCCCCTGGTACCTACTCGGGCCCCACCCAGCTGATACAGCCCAGG GCCCCAGGGCCCCATGCAATGCCCGTAGCACCTGGGCCTGCCCTCTACCCAGCCCCTGCC TACACACCGGAGCTGGGCCTTGTGCCCCGATCCTCCCCACAGCATGGCGTGGTGAGCAGT CCCTATGTGGGGGTAGGGCCGGCCCCACCAGTTGCAGGTCTCCCCTCGGCCCCACCTCCT CAATTCTCAGGCCCCGAGTTGGCCATGGCGGTTCGGCCAGCCACCACCACAGTAGATAGC ATCCAGGCGCCCATCCCCAGCCACACAGCCCCACGGCCAAACCCCACCCCTGCTCCTCCC CCGCCCTGCTTCCCTGTGCCCCCACCGCAGCCACTGCCCACGCCTTACACCTACCCTGCA GGGGCTAAGCAACCCATCCCGGCACAGCACCACTTCTCTTCTGGGATCCCCGCAGGTTTT CCAGCCCCAAGGATTGGGCCCCAGCCCCAGCCCCATCCTCAGCCCCATCCTTCACAAGCG TTTGGGCCTCAGCCCCCACAGCAGCCCCTTCCACTCCAGCATCCACATCTCTTCCCACCC CAGGCCCCAGGACTCCTACCCCCACAATCCCCCTACCCCTATGCCCCTCAGCCTGGGGTC CTGGGGCAGCCGCCACCCCCCCTACACACCCAGCTCTACCCAGGTCCCGCTCAAGACCCT CTGCCAGCCCACTCAGGGGCTCTGCCTTTCCCCAGCCCTGGGCCCCCTCAGCCTCCCCAT CCCCCACTGGCATATGGTCCTGCCCCTTCTACCAGACCCATGGGCCCCCAGGCAGCCCCT CTTACCATTCGAGGGCCCTCGTCTGCTGGCCAGTCCACCCCTAGTCCCCACCTGGTGCCT TCACCTGCCCCATCTCCAGGGCCTGGTCCGGTACCCCCTCGCCCCCCAGCAGCAGAACCA CCCCCTTGCCTGCGCCGAGGCGCCGCAGCTGCAGACCTGCTCTCCTCCAGCCCGGAGAGC CAGCATGGCGGCACTCAGTCTCCTGGGGGTGGGCAGCCCCTGCTGCAGCCCACCAAGGTG GATGCAGCTGAGGGTCGTCGGCCGCAGGCCCTGCGGCTGATTGAGCGGGACCCCTATGAG CATCCTGAGAGGCTGCGGCAGTTGCAGCAGGAGCTGGAGGCCTTTCGGGGTCAGCTGGGG GATGTGGGAGCTCTGGACACTGTCTGGCGAGAGCTGCAAGATGCGCAGGAACATGATGCC CGAGGCCGTTCCATCGCCATTGCCCGCTGCTACTCACTGAAGAACCGGCACCAGGATGTC ATGCCCTATGACAGTAACCGTGTGGTGCTGCGCTCAGGCAAGGATGACTACATCAATGCC AGCTGCGTGGAGGGGCTCTCCCCATACTGCCCCCCGCTAGTGGCAACCCAGGCCCCACTG CCTGGCACAGCTGCTGACTTCTGGCTCATGGTCCATGAGCAGAAAGTGTCAGTCATTGTC ATGCTGGTTTCTGAGGCTGAGATGGAGAAGCAAAAAGTGGCACGCTACTTCCCCACCGAG AGGGGCCAGCCCATGGTGCACGGTGCCCTGAGCCTGGCATTGAGCAGCGTCCGCAGCACC GAAACCCATGTGGAGCGCGTGCTGAGCCTGCAGTTCCGAGACCAGAGCCTCAAGCGCTCT CTTGTGCACCTGCACTTCCCCACTTGGCCTGAGTTAGGCCTGCCCGACAGCCCCAGCAAC TTGCTGCGCTTCATCCAGGAGGTGCACGCACATTACCTGCATCAGCGGCCGCTGCACACG CCCATCATTGTGCACTGCAGCTCTGGTGTGGGCCGCACGGGAGCCTTTGCACTGCTCTAT GCAGCTGTGCAGGAGGTGGAGGCTGGGAACGGAATCCCTGAGCTGCCTCAGCTGGTGCGG CGCATGCGGCAGCAGAGAAAGCACATGCTGCAGGAGAAGCTGCACCTCAGGTTCTGCTAT GAGGCAGTGGTGAGACACGTGGAGCAGGTCCTGCAGCGCCATGGTGTGCCTCCTCCATGC AAACCCTTGGCCAGTGCAAGCATCAGCCAGAAGAACCACCTTCCTCAGGACTCCCAGGAC CTGGTCCTCGGTGGGGATGTGCCCATCAGCTCCATCCAGGCCACCATTGCCAAGCTCAGC ATTCGGCCTCCTGGGGGGTTGGAGTCCCCGGTTGCCAGCTTGCCAGGCCCTGCAGAGCCC CCAGGCCTCCCGCCAGCCAGCCTCCCAGAGTCTACCCCAATCCCATCTTCCTCCCCGCCC CCCCTTTCCTCCCCACTACCTGAGGCTCCCCAGCCTAAGGAGGAGCCGCCAGTGCCTGAA GCCCCCAGCTCGGGGCCCCCCTCCTCCTCCCTGGAATTGCTGGCCTCCTTGACCCCAGAG GCCTTCTCCCTGGACAGCTCCCTGCGGGGCAAACAGCGGATGAGCAAGCATAACTTTCTG CAGGCCCATAACGGGCAAGGGCTGCGGGCCACCCGGCCCTCTGACGACCCCCTCAGCCTT CTGGATCCACTCTGGACACTCAACAAGACCTGA

GenBank 基因 ID

基因卡 ID

Genatlas ID

HGNC ID

HGNC:14406

染色体位置

3

轨迹

信号区域

Pdb标识

3RAU

KEGG ID

hsa:25930

细胞的位置

Nucleus