同义词

3.5.1.98; HD8; HDACL1

UniProt ID

Q9BY41

UniProt名字

HDAC8_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

HDAC8

生物

Human

氨基酸序列

>lcl|BSEQ0003191|Histone deacetylase 8 MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH RIQQILNYIKGNLKHVV

目标基因序列

残基数

377

分子量

41757.29

理论 pI

5.37

一般功能

Transcription factor binding

具体功能

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.

跨膜区

GenBank 蛋白质 ID

8118721

目标蛋白质序列

基因序列

>lcl|BSEQ0016492|Histone deacetylase 8 (HDAC8) ATGGAGGAGCCGGAGGAACCGGCGGACAGTGGGCAGTCGCTGGTCCCGGTTTATATCTAT AGTCCCGAGTATGTCAGTATGTGTGACTCCCTGGCCAAGATCCCCAAACGGGCCAGTATG GTGCATTCTTTGATTGAAGCATATGCACTGCATAAGCAGATGAGAGATGAAGCATCTGGT TTTTGTTATCTCAATGATGCTGTCCTGGGAATATTACGATTGCGACGGAAATTTGAGCGT ATTCTCTACGTGGATTTGGATCTGCACCATGGAGATGGTGTAGAAGACGCATTCAGTTTC ACCTCCAAAGTCATGACCGTGTCCCTGCACAAATTCTCCCCAGGATTTTTCCCAGGAACA GGTGACGTGTCTGATGTTGGCCTAGGGAAGGGACGGTACTACAGTGTAAATGTGCCCATT CAGGATGGCATACAAGATGAAAAATATTACCAGATCTGTGAAAGTGTACTAAAGGAAGTA TACCAAGCCTTTAATCCCAAAGCAGTGGTCTTACAGCTGGGAGCTGACACAATAGCTGGG GATCCCATGTGCTCCTTTAACATGACTCCAGTGGGAATTGGCAAGTGTCTTAAGTACATC CTTCAATGGCAGTTGGCAACACTCATTTTGGGAGGAGGAGGCTATAACCTTGCCAACACG GCTCGATGCTGGACATACTTGACCGGGGTCATCCTAGGGAAAACACTATCCTCTGAGATC CCAGATCATGAGTTTTTCACAGCATATGGTCCTGATTATGTGCTGGAAATCACGCCAAGC TGCCGGCCAGACCGCAATGAGCCCCACCGAATCCAACAAATCCTCAACTACATCAAAGGG AATCTGAAGCATGTGGTCTAG

GenBank 基因 ID

AF230097

基因卡 ID

Genatlas ID

HDAC8

HGNC ID

HGNC:13315

染色体位置

轨迹

Xq13

信号区域

Pdb标识

1T64; 1T67; 1T69; 1VKG; 1W22; 2V5W; 2V5X; 3EW8; 3EWF; 3EZP; 3EZT; 3F06; 3F07; 3F0R; 3MZ3; 3MZ4; 3MZ6; 3MZ7; 3RQD; 3SFF; 3SFH; 4QA0; 4QA1; 4QA2; 4QA3; 4QA4; 4QA5; 4QA6; 4QA7; 4RN0; 4RN1; 4RN2; 5D1B; 5D1C; 5D1D

KEGG ID

hsa:55869

细胞的位置

Nucleus