Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
同义词
3.1.3.27; MOSP; Phosphoinositide lipid phosphatase; PLIP; Protein-tyrosine phosphatase mitochondrial 1; PTEN-like phosphatase
氨基酸序列
>lcl|BSEQ0009020|Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
MAATALLEAGLARVLFYPTLLYTLFRGKVPGRAHRDWYHRIDPTVLLGALPLRSLTRQLV
QDENVRGVITMNEEYETRFLCNSSQEWKRLGVEQLRLSTVDMTGIPTLDNLQKGVQFALK
YQSLGQCVYVHCKAGRSRSATMVAAYLIQVHKWSPEEAVRAIAKIRSYIHIRPGQLDVLK
EFHKQITARATKDGTFVISKT
一般功能
Protein tyrosine/serine/threonine phosphatase activity
具体功能
Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).
基因序列
>lcl|BSEQ0017669|Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1)
ATGGCGGCCACCGCGCTGCTGGAGGCCGGCCTGGCGCGGGTGCTCTTCTACCCGACGCTG
CTCTACACCCTGTTCCGCGGGAAGGTGCCGGGTCGGGCGCACCGGGACTGGTACCACCGC
ATCGACCCCACCGTGCTGCTGGGCGCGCTGCCGTTGCGGAGCTTGACGCGCCAGGTGAGC
CGGGCCGGGGAGCCCGGGCCCCTGCCCCGTCCCCGCCGCTCCGTCCCTGTCGGGCCGCTG
GGGTCTCCACCGTCTTTGCTGAGCCACCTCTTTGCCTCGGCAGCTGGTACAGGACGAGAA
CGTGCGCGGGGTGATCACCATGAACGAGGAGTACGAGACGAGGTTCCTGTGCAACTCTTC
ACAGGTGCACAAATGGAGTCCAGAGGAGGCTGTAAGAGCCATCGCCAAGATCCGGTCATA
CATCCACATCAGGCCTGGCCAGCTGGATGTTCTTAA
细胞的位置
Mitochondrion inner membrane