同义词

1-acylglycerol-3-phosphate O-acyltransferase 11; 1-acylglycerophosphocholine O-acyltransferase; 1-AGP acyltransferase 11; 1-AGPAT 11; 1-alkylglycerophosphocholine O-acetyltransferase; 2.3.1.23; Acetyl-CoA:lyso-PAF acetyltransferase; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acyltransferase-like 1; AGPAT11; AYTL1; LPAAT-alpha; LPC acyltransferase 2; Lyso-PAF acetyltransferase; LysoPAFAT; Lysophosphatidic acid acyltransferase alpha

UniProt ID

Q7L5N7

UniProt名字

PCAT2_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

LPCAT2

生物

Human

氨基酸序列

>lcl|BSEQ0008839|Lysophosphatidylcholine acyltransferase 2 MSRCAQAAEVAATVPGAGVGNVGLRPPMVPRQASFFPPPVPNPFVQQTQIGSARRVQIVL LGIILLPIRVLLVALILLLAWPFAAISTVCCPEKLTHPITGWRRKITQTALKFLGRAMFF SMGFIVAVKGKIASPLEAPVFVAAPHSTFFDGIACVVAGLPSMVSRNENAQVPLIGRLLR AVQPVLVSRVDPDSRKNTINEIIKRTTSGGEWPQILVFPEGTCTNRSCLITFKPGAFIPG VPVQPVLLRYPNKLDTVTWTWQGYTFIQLCMLTFCQLFTKVEVEFMPVQVPNDEEKNDPV LFANKVRNLMAEALGIPVTDHTYEDCRLMISAGQLTLPMEAGLVEFTKISRKLKLDWDGV RKHLDEYASIASSSKGGRIGIEEFAKYLKLPVSDVLRQLFALFDRNHDGSIDFREYVIGL AVLCNPSNTEEIIQVAFKLFDVDEDGYITEEEFSTILQASLGVPDLDVSGLFKEIAQGDS ISYEEFKSFALKHPEYAKIFTTYLDLQTCHVFSLPKEVQTTPSTASNKVSPEKHEESTSD KKDD

目标基因序列

残基数

544

分子量

60207.295

理论 pI

一般功能

Calcium ion binding

具体功能

Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine.

跨膜区

58-78

GenBank 蛋白质 ID

目标蛋白质序列

基因序列

>lcl|BSEQ0019672|Lysophosphatidylcholine acyltransferase 2 (LPCAT2) ATGAGCCGGTGCGCCCAGGCGGCGGAAGTGGCGGCCACAGTGCCAGGTGCCGGCGTCGGG AACGTGGGGCTGCGGCCGCCCATGGTGCCCCGTCAGGCGTCCTTCTTCCCGCCGCCGGTG CCGAACCCCTTCGTGCAGCAGACGCAGATCGGCTCCGCGAGGCGGGTCCAGATTGTCCTT CTTGGGATTATCTTGCTTCCAATTCGTGTCTTATTGGTTGCGTTAATTTTATTACTTGCA TGGCCATTTGCTGCAATTTCAACAGTATGCTGTCCTGAAAAGCTGACCCACCCAATAACT GGTTGGAGGAGGAAAATTACTCAAACAGCTTTGAAATTTCTGGGTCGTGCTATGTTCTTT TCAATGGGATTTATAGTTGCTGTAAAAGGAAAGATTGCAAGTCCTTTGGAAGCACCAGTT TTTGTTGCTGCCCCTCATTCAACATTCTTTGATGGAATTGCCTGTGTTGTAGCTGGGTTA CCTTCTATGGTATCTCGAAATGAGAATGCACAAGTCCCTCTGATTGGCAGACTGTTACGG GCTGTGCAACCAGTTTTGGTGTCCCGTGTAGATCCGGATTCCCGAAAAAACACAATAAAT GAAATAATAAAGCGAACAACATCAGGAGGAGAATGGCCCCAGATACTAGTTTTCCCAGAA GGTACTTGTACTAATCGTTCCTGTTTGATTACTTTTAAACCAGGAGCCTTCATTCCAGGA GTTCCAGTGCAGCCAGTCCTCCTCAGATACCCAAACAAGCTGGATACTGTGACCTGGACA TGGCAAGGATATACATTCATTCAGCTTTGTATGCTTACTTTCTGCCAGCTCTTCACAAAG GTAGAAGTTGAGTTTATGCCAGTTCAAGTACCAAATGATGAAGAAAAAAATGATCCTGTC CTTTTTGCCAATAAAGTCCGGAATTTAATGGCAGAAGCTCTGGGAATACCAGTAACAGAT CATACCTATGAAGACTGCAGATTGATGATTTCAGCAGGACAGCTAACATTGCCTATGGAA GCTGGGCTGGTGGAATTTACTAAAATTAGCCGAAAATTGAAATTAGATTGGGATGGTGTT CGTAAGCATTTGGATGAATATGCATCTATTGCGAGTTCCTCAAAAGGAGGAAGAATTGGA ATTGAAGAATTCGCCAAGTATTTAAAGTTGCCTGTTTCAGATGTCTTGAGACAACTTTTT GCACTCTTTGACAGGAACCATGATGGCAGCATTGACTTCCGAGAGTATGTGATTGGCCTG GCTGTCTTGTGCAACCCTTCCAACACAGAGGAGATCATCCAGGTGGCATTTAAGCTGTTT GACGTTGATGAGGATGGCTACATAACGGAGGAAGAGTTCTCCACCATTCTACAGGCTTCC CTTGGAGTGCCTGACCTTGATGTTTCTGGTCTCTTCAAGGAAATAGCCCAAGGGGACTCA ATTTCCTATGAGGAATTTAAAAGTTTTGCCTTAAAGCATCCAGAATATGCTAAGATATTT ACAACATACCTAGACCTCCAGACGTGCCATGTGTTTTCATTACCAAAAGAAGTCCAGACA ACCCCCTCCACCGCCAGTAATAAAGTCAGCCCTGAAAAGCATGAAGAGAGTACCTCAGAC AAAAAAGATGACTGA

GenBank 基因 ID

基因卡 ID

Genatlas ID

HGNC ID

HGNC:26032

染色体位置

16

轨迹

信号区域

Pdb标识

KEGG ID

hsa:54947

细胞的位置

Endoplasmic reticulum membrane