同义词

1.14.11.33; ABH2; Alkylated DNA repair protein alkB homolog 2; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; Oxy DC1

UniProt ID

Q6NS38

UniProt名字

ALKB2_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

ALKBH2

生物

Human

氨基酸序列

>lcl|BSEQ0004327|DNA oxidative demethylase ALKBH2 MDRFLVKGAQGGLLRKQEEQEPTGEEPAVLGGDKESTRKRPRREAPGNGGHSAGPSWRHI RAEGLDCSYTVLFGKAEADEIFQELEKEVEYFTGALARVQVFGKWHSVPRKQATYGDAGL TYTFSGLTLSPKPWIPVLERIRDHVSGVTGQTFNFVLINRYKDGCDHIGEHRDDERELAP GSPIASVSFGACRDFVFRHKDSRGKSPSRRVAVVRLPLAHGSLLMMNHPTNTHWYHSLPV RKKVLAPRVNLTFRKILLTKK

目标基因序列

残基数

261

分子量

29322.22

理论 pI

10.22

一般功能

Ferrous iron binding

具体功能

Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.

跨膜区

GenBank 蛋白质 ID

53988530

目标蛋白质序列

基因序列

>lcl|BSEQ0020600|DNA oxidative demethylase ALKBH2 (ALKBH2) ATGGACAGATTCCTGGTGAAAGGGGCTCAAGGGGGCCTTTTGAGGAAGCAGGAGGAGCAA GAGCCAACTGGAGAAGAGCCAGCTGTGTTGGGAGGAGACAAAGAAAGCACAAGGAAGAGG CCCAGGAGAGAGGCCCCAGGGAATGGAGGCCACTCAGCAGGCCCTAGCTGGCGGCACATT CGGGCTGAGGGCCTGGACTGCAGTTACACAGTCCTGTTTGGCAAAGCTGAGGCAGATGAG ATTTTCCAAGAGTTGGAGAAAGAAGTAGAATATTTTACAGGAGCACTGGCCAGAGTCCAG GTATTCGGGAAGTGGCACAGTGTGCCCAGGAAGCAGGCAACGTATGGCGACGCTGGGCTG ACCTACACATTTTCAGGCCTCACGCTGTCTCCAAAGCCCTGGATCCCAGTTCTAGAGCGC ATCCGGGATCACGTCTCTGGGGTGACTGGACAGACCTTCAACTTTGTGCTCATCAACAGG TATAAAGATGGCTGTGACCACATCGGGGAGCACCGAGATGATGAAAGAGAACTGGCCCCT GGGAGCCCCATTGCCTCTGTCTCCTTCGGTGCCTGCAGAGACTTTGTCTTCCGGCATAAG GATTCCCGTGGGAAAAGCCCCTCCAGGAGGGTGGCGGTGGTCAGGCTGCCGCTGGCCCAC GGGAGCTTACTAATGATGAACCACCCGACCAACACGCACTGGTACCACAGTCTTCCCGTG AGAAAGAAGGTTCTGGCTCCACGGGTGAATCTGACTTTTCGTAAAATTTTGCTTACTAAA AAATAA

GenBank 基因 ID

AY754389

基因卡 ID

Genatlas ID

ALKBH2

HGNC ID

HGNC:32487

染色体位置

12

轨迹

12q24.11

信号区域

Pdb标识

3BTX; 3BTY; 3BTZ; 3BU0; 3BUC; 3H8O; 3H8R; 3H8X; 3RZG; 3RZH; 3RZJ; 3RZK; 3RZL; 3RZM; 3S57; 3S5A; 4MG2; 4MGT

KEGG ID

hsa:121642

细胞的位置

Nucleus