同义词

BK channel subunit beta-1; BKbeta; BKbeta1; Calcium-activated potassium channel subunit beta; Calcium-activated potassium channel, subfamily M subunit beta-1; Charybdotoxin receptor subunit beta-1; Hbeta1; K(VCA)beta-1; Maxi K channel subunit beta-1; Slo-beta; Slo-beta-1

UniProt ID

Q16558

UniProt名字

KCMB1_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

KCNMB1

生物

Human

氨基酸序列

>lcl|BSEQ0037281|Calcium-activated potassium channel subunit beta-1 MVKKLVMAQKRGETRALCLGVTMVVCAVITYYILVTTVLPLYQKSVWTQESKCHLIETNI RDQEELKGKKVPQYPCLWVNVSAAGRWAVLYHTEDTRDQNQQCSYIPGSVDNYQTARADV EKVRAKFQEQQVFYCFSAPRGNETSVLFQRLYGPQALLFSLFWPTFLLTGGLLIIAMVKS NQYLSILAAQK

目标基因序列

残基数

191

分子量

21797.27

理论 pI

8.76

一般功能

Potassium channel regulator activity

具体功能

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.

跨膜区

19-39 158-178

GenBank 蛋白质 ID

1326067

目标蛋白质序列

基因序列

>lcl|BSEQ0013099|Calcium-activated potassium channel subunit beta-1 (KCNMB1) ATGGTGAAGAAGCTGGTGATGGCCCAGAAGCGGGGAGAGACACGAGCCCTTTGCCTGGGT GTAACCATGGTGGTGTGTGCCGTCATCACCTACTACATCCTGGTCACGACTGTGCTGCCC CTCTACCAGAAAAGCGTGTGGACCCAGGAATCCAAGTGCCACCTGATTGAGACCAACATC AGGGACCAGGAGGAGCTGAAGGGCAAGAAGGTGCCCCAGTACCCATGCCTGTGGGTCAAC GTGTCAGCTGCCGGCAGGTGGGCTGTGCTGTACCACACGGAGGACACTCGGGACCAGAAC CAGCAGTGCTCCTACATCCCAGGCAGCGTGGACAATTACCAGACGGCCCGGGCCGACGTG GAGAAGGTCAGAGCCAAATTCCAAGAGCAGCAGGTCTTCTACTGCTTCTCCGCACCTCGG GGGAACGAAACCAGCGTCCTATTCCAGCGCCTCTACGGGCCCCAGGCCCTCCTCTTCTCC CTCTTCTGGCCCACCTTCCTGCTGACCGGTGGCCTCCTCATTATCGCCATGGTGAAGAGC AACCAGTACCTGTCCATCCTGGCGGCCCAGAAGTAG

GenBank 基因 ID

U25138

基因卡 ID

Genatlas ID

HGNC ID

HGNC:6285

染色体位置

5

轨迹

5q34

信号区域

Pdb标识

KEGG ID

hsa:3779

细胞的位置

Membrane