同义词

IB-2; IB2; Islet-brain-2; JIP-2; JIP2; JNK MAP kinase scaffold protein 2; Mitogen-activated protein kinase 8-interacting protein 2; PRKM8IPL

UniProt ID

Q13387

UniProt名字

JIP2_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

MAPK8IP2

生物

Human

氨基酸序列

>lcl|BSEQ0008804|C-Jun-amino-terminal kinase-interacting protein 2 MADRAEMFSLSTFHSLSPPGCRPPQDISLEEFDDEDLSEITDDCGLGLSYDSDHCEKDSL SLGRSEQPHPICSFQDDFQEFEMIDDNEEEDDEDEEEEEEEEEGDGEGQEGGDPGSEAPA PGPLIPSPSVEEPHKHRPTTLRLTTLGAQDSLNNNGGFDLVRPASWQETALCSPAPEALR ELPGPLPATDTGPGGAQSPVRPGCDCEGNRPAEPPAPGGTSPSSDPGIEADLRSRSSGGR GGRRSSQELSSPGSDSEDAGGARLGRMISSISETELELSSDGGSSSSGRSSHLTNSIEEA SSPASEPEPPREPPRRPAFLPVGPDDTNSEYESGSESEPDLSEDADSPWLLSNLVSRMIS EGSSPIRCPGQCLSPAPRPPGEPVSPAGGAAQDSQDPEAAAGPGGVELVDMETLCAPPPP APAAPRPGPAQPGPCLFLSNPTRDTITPLWAAPGRAARPGRACSAACSEEEDEEDDEEEE DAEDSAGSPGGRGTGPSAPRDASLVYDAVKYTLVVDEHTQLELVSLRRCAGLGHDSEEDS GGEASEEEAGAALLGGGQVSGDTSPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLV NGEEREQTHRAVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYA HAVPGPAKDLLGSKRSPCWVERFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLR PPASCDLEISLRGVKLSLSGGGPEFQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLS RFACHVFVSQESMRPVAQSVGRAFLEYYQEHLAYACPTEDIYLE

目标基因序列

残基数

824

分子量

87973.915

理论 pI

一般功能

Structural molecule activity

具体功能

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity).

跨膜区

GenBank 蛋白质 ID

目标蛋白质序列

基因序列

>lcl|BSEQ0013424|C-Jun-amino-terminal kinase-interacting protein 2 (MAPK8IP2) ATGGCGGATCGCGCGGAGATGTTTTCTCTCTCCACCTTCCACTCGCTGTCGCCGCCGGGC TGCAGGCCTCCCCAGGACATAAGCCTGGAAGAATTTGACGACGAAGATCTGTCTGAGATC ACTGATGACTGTGGCCTGGGCCTCAGCTACGACTCAGACCACTGTGAGAAGGACAGCCTC TCCCTGGGGCGCTCGGAGCAGCCGCACCCCATCTGCTCCTTCCAGGATGACTTCCAGGAG TTTGAGATGATCGATGACAATGAAGAGGAGGACGATGAGGACGAGGAAGAGGAGGAGGAG GAGGAGGAGGGAGATGGGGAAGGCCAGGAGGGAGGAGACCCTGGCTCAGAGGCACCTGCC CCCGGGCCCCTTATCCCCTCCCCTTCCGTGGAGGAGCCCCACAAGCACCGGCCCACCACC CTCCGTCTGACCACACTGGGGGCCCAGGACTCCCTAAACAACAACGGAGGCTTTGACCTG GTGCGTCCGGCCTCCTGGCAGGAGACAGCGCTATGCTCACCCGCCCCGGAGGCCCTCAGA GAGCTCCCGGGCCCCCTCCCTGCCACGGACACCGGGCCCGGCGGGGCGCAGTCGCCAGTG CGCCCGGGTTGCGACTGCGAAGGGAACCGGCCTGCGGAACCCCCTGCGCCAGGGGGGACT TCGCCCTCCTCAGATCCCGGCATCGAGGCTGACCTGAGAAGCCGCTCGAGCGGCGGCCGC GGGGGACGTCGCAGCAGCCAGGAGCTGTCCTCGCCCGGCTCCGACTCGGAGGACGCGGGC GGCGCGCGCCTGGGGCGCATGATCTCGTCCATCTCGGAGACGGAGCTGGAGCTGAGCAGC GATGGCGGAAGCAGCAGCAGCGGCCGCTCCTCGCACCTCACCAACTCCATCGAGGAGGCC TCGTCGCCCGCCTCGGAGCCGGAGCCCCCGCGCGAACCCCCGCGCCGCCCCGCCTTCCTG CCCGTGGGCCCCGACGACACCAACAGCGAGTACGAGTCGGGGTCGGAGTCGGAGCCGGAC CTCAGCGAGGACGCGGACTCGCCCTGGCTGCTCAGCAACCTGGTGAGCCGCATGATCTCC GAGGGCTCCTCGCCCATCCGCTGCCCCGGCCAGTGCCTGTCTCCTGCGCCGCGCCCGCCC GGGGAGCCCGTGTCGCCGGCCGGCGGGGCCGCCCAGGACTCCCAGGACCCCGAGGCGGCC GCGGGGCCCGGCGGCGTGGAGCTGGTGGACATGGAGACGCTGTGCGCGCCGCCGCCGCCC GCGCCCGCCGCGCCTCGACCCGGCCCCGCGCAGCCCGGGCCCTGCCTATTCCTCAGCAAC CCCACGCGTGACACCATCACGCCGCTGTGGGCCGCGCCCGGCCGCGCCGCCCGCCCGGGA CGAGCCTGCTCCGCCGCCTGCTCCGAGGAGGAGGACGAAGAGGACGACGAGGAAGAGGAG GATGCCGAGGACAGTGCGGGGTCCCCCGGGGGCAGGGGCACGGGCCCCTCGGCGCCGCGG GACGCGTCGCTGGTGTACGACGCGGTCAAGTACACGCTGGTGGTGGATGAGCACACGCAG CTGGAGCTGGTGAGCCTGCGGCGCTGTGCTGGGCTGGGCCACGACAGCGAAGAGGACAGC GGCGGGGAGGCCAGCGAGGAGGAGGCGGGCGCGGCGCTGCTAGGCGGCGGTCAGGTCTCG GGGGACACCTCGCCGGACAGCCCTGACCTCACTTTCTCCAAGAAGTTCCTCAATGTCTTC GTCAACAGCACATCTCGGTCCTCCAGCACCGAGTCCTTTGGCCTTTTCTCCTGTCTGGTC AACGGCGAGGAGCGAGAGCAGACTCACCGGGCTGTGTTCAGGTTCATCCCGCGGCATCCA GACGAGCTGGAGCTGGATGTGGATGACCCTGTGTTGGTGGAGGCCGAGGAGGACGACTTC TGGTTCCGTGGCTTCAACATGCGCACGGGGGAGCGCGGTGTGTTTCCTGCCTTCTACGCC CATGCGGTGCCCGGCCCTGCCAAGGACCTGCTGGGGAGTAAGCGGAGCCCCTGCTGGGTG GAGCGCTTTGACGTGCAGTTCCTGGGCTCCGTGGAGGTGCCCTGCCACCAGGGCAACGGC ATCCTGTGTGCAGCCATGCAGAAGATTGCCACTGCCCGGAAACTGACCGTCCACCTGCGC CCTCCTGCCTCCTGTGACCTCGAGATCTCTCTTCGGGGGGTCAAGCTGAGTCTGAGCGGA GGAGGGCCCGAGTTCCAGCGCTGCAGCCATTTCTTCCAGATGAAGAACATCTCCTTCTGC GGCTGCCATCCCCGCAACAGCTGCTATTTCGGCTTCATCACCAAACACCCCCTGCTGAGC CGCTTCGCCTGCCACGTCTTTGTCTCCCAGGAGTCCATGAGGCCGGTGGCGCAGAGTGTG GGCCGCGCCTTCCTGGAGTACTACCAAGAGCACCTGGCGTACGCCTGCCCCACGGAGGAC ATCTACCTGGAGTAG

GenBank 基因 ID

基因卡 ID

Genatlas ID

HGNC ID

HGNC:6883

染色体位置

22

轨迹

信号区域

Pdb标识

KEGG ID

hsa:23542

细胞的位置

Cytoplasm