同义词

H3.3A; H3.3B; H3F3

UniProt ID

P84243

UniProt名字

H33_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

H3F3A

生物

Human

氨基酸序列

>lcl|BSEQ0008753|Histone H3.3 MARTKQTARKSTGGKAPRKQLATKAARKSAPSTGGVKKPHRYRPGTVALREIRRYQKSTE LLIRKLPFQRLVREIAQDFKTDLRFQSAAIGALQEASEAYLVGLFEDTNLCAIHAKRVTI MPKDIQLARRIRGERA

目标基因序列

残基数

136

分子量

15327.745

理论 pI

一般功能

Rna polymerase ii distal enhancer sequence-specific dna binding

具体功能

Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

跨膜区

GenBank 蛋白质 ID

目标蛋白质序列

基因序列

>lcl|BSEQ0013395|Histone H3.3 (H3F3A) ATGGCTCGTACAAAGCAGACTGCCCGCAAATCGACCGGTGGTAAAGCACCCAGGAAGCAA CTGGCTACAAAAGCCGCTCGCAAGAGTGCGCCCTCTACTGGAGGGGTGAAGAAACCTCAT CGTTACAGGCCTGGTACTGTGGCGCTCCGTGAAATTAGACGTTATCAGAAGTCCACTGAA CTTCTGATTCGCAAACTTCCCTTCCAGCGTCTGGTGCGAGAAATTGCTCAGGACTTTAAA ACAGATCTGCGCTTCCAGAGCGCAGCTATCGGTGCTTTGCAGGAGGCAAGTGAGGCCTAT CTGGTTGGCCTTTTTGAAGACACCAACCTGTGTGCTATCCATGCCAAACGTGTAACAATT ATGCCAAAAGACATCCAGCTAGCACGCCGCATACGTGGAGAACGTGCTTAA

GenBank 基因 ID

基因卡 ID

Genatlas ID

HGNC ID

HGNC:4764

染色体位置

17

轨迹

信号区域

Pdb标识

2L43; 3ASK; 3ASL; 3AV2; 3JVK; 3MUK; 3MUL; 3QL9; 3QLA; 3QLC; 3WTP; 4GNE; 4GNF; 4GNG; 4GU0; 4GUR; 4GUS; 4GY5; 4H9N; 4H9O; 4H9P; 4H9Q; 4H9R; 4H9S; 4HGA; 4L58; 4N4I; 4O62; 4QQ4; 4TMP; 4U7T; 4W5A; 5BNV; 5BNX

KEGG ID

hsa:3020

细胞的位置

Nucleus