同义词

H4/A; H4/B; H4/C; H4/D; H4/E; H4/G; H4/H; H4/I; H4/J; H4/K; H4/M; H4/N; H4/O; H4F2; H4FA; H4FB; H4FC; H4FD; H4FE; H4FG; H4FH; H4FI; H4FJ; H4FK; H4FM; H4FN; H4FO; HIST2H4

UniProt ID

P62805

UniProt名字

H4_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

HIST1H4A

生物

Human

氨基酸序列

>lcl|BSEQ0008763|Histone H4 MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLK VFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

目标基因序列

残基数

103

分子量

11367.3

理论 pI

一般功能

Protein domain specific binding

具体功能

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

跨膜区

GenBank 蛋白质 ID

目标蛋白质序列

基因序列

>lcl|BSEQ0013402|Histone H4 (HIST1H4A) ATGTCTGGGCGAGGTAAAGGTGGCAAGGGGCTGGGTAAGGGAGGCGCCAAGCGCCACCGG AAGGTGCTGCGGGACAATATCCAAGGCATTACAAAGCCGGCGATTCGCCGTCTCGCCCGA CGTGGGGGCGTCAAGCGCATTTCTGGTCTCATCTACGAGGAGACCCGGGGAGTCCTCAAA GTCTTCCTGGAGAACGTGATCCGTGACGCGGTGACTTACACGGAGCACGCCAAGCGCAAG ACCGTCACGGCCATGGATGTGGTGTACGCGCTGAAACGCCAGGGTCGCACCCTTTATGGT TTCGGCGGTTGA

GenBank 基因 ID

基因卡 ID

Genatlas ID

HGNC ID

HGNC:4781

染色体位置

1

轨迹

信号区域

Pdb标识

1ZKK; 2BQZ; 2CV5; 2IG0; 2KWN; 2KWO; 2LVM; 2QQS; 2RJE; 2RNY; 2RS9; 3A6N; 3AFA; 3AN2; 3AV1; 3AV2; 3AYW; 3AZE; 3AZF; 3AZG; 3AZH; 3AZI; 3AZJ; 3AZK; 3AZL; 3AZM; 3AZN; 3CFS; 3CFV; 3F9W; 3F9X; 3F9Y; 3F9Z; 3IJ1; 3JPX; 3NQJ; 3NQU; 3O36; 3QBY; 3QZS; 3QZT; 3QZV; 3R45; 3UVW; 3UVX; 3UVY; 3UW9; 3W96; 3W97; 3W98; 3W99; 3WA9; 3WAA; 3WKJ; 3WTP; 3X1S; 3X1T; 3X1U; 3X1V; 4GQB; 4H9N; 4H9O; 4H9P; 4H9Q; 4H9R; 4H9S; 4HGA; 4M38; 4N3W; 4N4F; 4QUT; 4QUU; 4QYD; 4U9W; 4YY6; 4YYD; 4YYG; 4YYH; 4YYI; 4YYJ; 4YYK; 4YYM; 4YYN; 5BNV; 5BNX; 5BO0; 5C3I; 5CPI; 5CPJ; 5CPK

KEGG ID

hsa:121504

细胞的位置

Nucleus