同义词

CENP-A; Centromere autoantigen A; Centromere protein A

UniProt ID

P49450

UniProt名字

CENPA_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

CENPA

生物

Human

氨基酸序列

>lcl|BSEQ0008859|Histone H3-like centromeric protein A MGPRRRSRKPEAPRRRSPSPTPTPGPSRRGPSLGASSHQHSRRRQGWLKEIRKLQKSTHL LIRKLPFSRLAREICVKFTRGVDFNWQAQALLALQEAAEAFLVHLFEDAYLLTLHAGRVT LFPKDVQLARRIRGLEEGLG

目标基因序列

残基数

140

分子量

15990.395

理论 pI

一般功能

Dna binding

具体功能

Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).

跨膜区

GenBank 蛋白质 ID

目标蛋白质序列

基因序列

>lcl|BSEQ0013459|Histone H3-like centromeric protein A (CENPA) ATGGGCCCGCGCCGCCGGAGCCGAAAGCCCGAGGCCCCGAGGAGGCGCAGCCCGAGCCCG ACCCCGACCCCCGGCCCCTCCCGGCGGGGCCCCTCCTTAGGCGCTTCCTCCCATCAACAC AGTCGGCGGAGACAAGGTTGGCTAAAGGAGATCCGAAAGCTTCAGAAGAGCACACACCTC TTGATAAGGAAGCTGCCCTTCAGCCGCCTGGCAGCAGAAGCATTTCTAGTTCATCTCTTT GAGGACGCCTATCTCCTCACCTTACATGCAGGCCGAGTTACTCTCTTCCCAAAGGATGTG CAACTGGCCCGGAGGATCCGGGGCCTTGAGGAGGGACTCGGCTGA

GenBank 基因 ID

基因卡 ID

Genatlas ID

HGNC ID

HGNC:1851

染色体位置

2

轨迹

信号区域

Pdb标识

3AN2; 3NQJ; 3NQU; 3R45; 3WTP

KEGG ID

hsa:1058

细胞的位置

Nucleus