同义词

1.11.1.12; Glutathione peroxidase 4; GPx-4; GSHPx-4; PHGPx

UniProt ID

P36969

UniProt名字

GPX4_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

GPX4

生物

Human

氨基酸序列

>lcl|BSEQ0037127|Phospholipid hydroperoxide glutathione peroxidase, mitochondrial MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR GFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRY GPMEEPLVIEKDLPHYF

目标基因序列

残基数

197

分子量

22174.52

理论 pI

8.41

一般功能

Phospholipid-hydroperoxide glutathione peroxidase activity

具体功能

Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage.

跨膜区

GenBank 蛋白质 ID

825667

目标蛋白质序列

基因序列

>lcl|BSEQ0010793|Phospholipid hydroperoxide glutathione peroxidase, mitochondrial (GPX4) ATGAGCCTCGGCCGCCTTTGCCGCCTACTGAAGCCGGCGCTGCTCTGTGGGGCTCTGGCC GCGCCTGGCCTGGCCGGGACCATGTGCGCGTCCCGGGACGACTGGCGCTGTGCGCGCTCC ATGCACGAGTTTTCCGCCAAGGACATCGACGGGCACATGGTTAACCTGGACAAGTACCGG GGCTTCGTGTGCATCGTCACCAACGTGGCCTCCCAGTGAGGCAAGACCGAAGTAAACTAC ACTCAGCTCGTCGACCTGCACGCCCGATACGCTGAGTGTGGTTTGCGGATCCTGGCCTTC CCGTGTAACCAGTTCGGGAAGCAGGAGCCAGGGAGTAACGAAGAGATCAAAGAGTTCGCC GCGGGCTACAACGTCAAATTCGATATGTTCAGCAAGATCTGCGTGAACGGGGACGACGCC CACCCGCTGTGGAAGTGGATGAAGATCCAACCCAAGGGCAAGGGCATCCTGGGAAATGCC ATCAAGTGGAACTTCACCAAGTTTGGACACCGTCTCTCCACAGTTCCTCATCGACAAGAA CGGCTGCGTGGTGAAGCGCTACGGACCCATGGAGGAGCCCCTGGTGATAGAGAAGGACCT GCCCCACTATTTCTAGCTCCACAAGTGTGTGGCCCCGCCCGAGCCCCTGCCCACGCCCTT GGAGCCTTCCACCGGCACTCATGA

GenBank 基因 ID

X71973

基因卡 ID

Genatlas ID

GPX4

HGNC ID

HGNC:4556

染色体位置

19

轨迹

19p13.3

信号区域

Pdb标识

2GS3; 2OBI

KEGG ID

hsa:2879

细胞的位置

Mitochondrion