同义词

BZRP; MBR; Mitochondrial benzodiazepine receptor; PBR; Peripheral-type benzodiazepine receptor; PKBS

UniProt ID

P30536

UniProt名字

TSPOA_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

TSPO

生物

Human

氨基酸序列

>lcl|BSEQ0037065|Translocator protein MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAM GYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAA ATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE

目标基因序列

残基数

169

分子量

18827.81

理论 pI

9.33

一般功能

Cholesterol binding

具体功能

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:24814875), but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (PubMed:1847678).

跨膜区

6-26 47-67 80-100 106-126 135-155

GenBank 蛋白质 ID

306883

目标蛋白质序列

基因序列

>lcl|BSEQ0016193|Translocator protein (TSPO) ATGGCCCCGCCCTGGGTGCCCGCCATGGGCTTCACGCTGGCGCCCAGCCTGGGGTGCTTC GTGGGCTCCCGCTTTGTCCACGGCGAGGGTCTCCGCTGGTACGCCGGCCTGCAGAAGCCC TCGTGGCACCCGCCCCACTGGGTGCTGGGCCCTGTCTGGGGCACGCTCTACTCAGCCATG GGGTACGGCTCCTACCTGGTCTGGAAAGAGCTGGGAGGCTTCACAGAGAAGGCTGTGGTT CCCCTGGGCCTCTACACTGGGCAGCTGGCCCTGAACTGGGCATGGCCCCCCATCTTCTTT GGTGCCCGACAAATGGGCTGGGCCTTGGTGGATCTCCTGCTGGTCAGTGGGGCGGCGGCA GCCACTACCGTGGCCTGGTACCAGGTGAGCCCGCTGGCCGCCCGCCTGCTCTACCCCTAC CTGGCCTGGCTGGCCTTCACGACCACACTCAACTACTGCGTATGGCGGGACAACCATGGC TGGCGTGGGGGACGGCGGCTGCCAGAGTGA

GenBank 基因 ID

M36035

基因卡 ID

Genatlas ID

TSPO

HGNC ID

HGNC:1158

染色体位置

22

轨迹

22q13.31

信号区域

Pdb标识

KEGG ID

hsa:706

细胞的位置

Mitochondrion membrane