同义词

5.2.1.8; Cyclophilin D; Cyclophilin F; CyP-D; CyP-M; CYP3; CypD; Mitochondrial cyclophilin; PPIase F; Rotamase F

UniProt ID

P30405

UniProt名字

PPIF_HUMAN

目标UniProt ID

NCBI分类Id

9606

基因名称

PPIF

生物

Human

氨基酸序列

>lcl|BSEQ0002777|Peptidyl-prolyl cis-trans isomerase F, mitochondrial MLALRCGSRWLGLLSVPRSVPLRLPAARACSKGSGDPSSSSSSGNPLVYLDVDANGKPLG RVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPSFMCQAGDFTNHNGTGGKSI YGSRFPDENFTLKHVGPGVLSMANAGPNTNGSQFFICTIKTDWLDGKHVVFGHVKEGMDV VKKIESFGSKSGRTSKKIVITDCGQLS

目标基因序列

残基数

207

分子量

22040.09

理论 pI

9.95

一般功能

Peptidyl-prolyl cis-trans isomerase activity

具体功能

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.

跨膜区

GenBank 蛋白质 ID

181274

目标蛋白质序列

基因序列

>lcl|BSEQ0021846|Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF) ATGCTGGCGCTGCGCTGCGGCTCCCGCTGGCTCGGCCTGCTCTCCGTCCCGCGCTCCGTG CCGCTGCGCCTCCCCGCGGCCCGCGCCTGCAGCAAGGGCTCCGGCGACCCGTCCTCTTCC TCCTCCTCCGGGAACCCGCTCGTGTACCTGGACGTGGACGCCAACGGGAAGCCGCTCGGC CGCGTGGTGCTGGAGCTGAAGGCAGATGTCGTCCCAAAGACAGCTGAGAACTTCAGAGCC CTGTGCACTGGTGAGAAGGGCTTCGGCTACAAAGGCTCCACCTTCCACAGGGTGATCCCT TCCTTCATGTGCCAGGCGGGCGACTTCACCAACCACAATGGCACAGGCGGGAAGTCCATC TACGGAAGCCGCTTTCCTGACGAGAACTTTACACTGAAGCACGTGGGGCCAGGTGTCCTG TCCATGGCTAATGCTGGTCCTAACACCAACGGCTCCCAGTTCTTCATCTGCACCATAAAG ACAGACTGGTTGGATGGCAAGCATGTTGTGTTCGGTCACGTCAAAGAGGGCATGGACGTC GTGAAGAAAATAGAATCTTTCGGCTCTAAGAGTGGGAGGACATCCAAGAAGATTGTCATC ACAGACTGTGGCCAGTTGAGCTAA

GenBank 基因 ID

M80254

基因卡 ID

Genatlas ID

PPIF

HGNC ID

HGNC:9259

染色体位置

10

轨迹

10q22-q23

信号区域

Pdb标识

2BIT; 2BIU; 2Z6W; 3QYU; 3R49; 3R4G; 3R54; 3R56; 3R57; 3R59; 3RCF; 3RCG; 3RCI; 3RCK; 3RCL; 3RD9; 3RDA; 3RDB; 3RDC; 4J58; 4J59; 4J5A; 4J5B; 4J5C; 4J5D; 4J5E; 4O8H; 4O8I; 4XNC; 4ZSC; 4ZSD

KEGG ID

hsa:10105

细胞的位置

Mitochondrion matrix