Receptor-type tyrosine-protein phosphatase beta
同义词
3.1.3.48; Protein-tyrosine phosphatase beta; PTPB; Vascular endothelial protein tyrosine phosphatase; VE-PTP
氨基酸序列
>lcl|BSEQ0037258|Receptor-type tyrosine-protein phosphatase beta
MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSS
DTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSK
EKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYN
IAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKG
ILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTND
GSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSC
VSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLL
NITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANE
TSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISG
DLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNES
ISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYL
SVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYE
NHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPK
SENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWS
GANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAF
IEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFE
HTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAA
GVAERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTE
GRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFS
FQNLLQGRMYKMVIVTHSGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGD
FDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTA
PSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVY
GLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDS
DFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDS
TITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDE
LKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCD
PTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAI
EGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTS
CPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYD
ATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVM
VTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLI
RHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRI
LQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPI
YENVNPEYHRDPVYSRH
一般功能
Transmembrane receptor protein tyrosine phosphatase activity
具体功能
Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).
基因序列
>lcl|BSEQ0019468|Receptor-type tyrosine-protein phosphatase beta (PTPRB)
ATGGAGGCTGAATTTTACATGGTGATTCTTACCTGCTTGATCTTCAGGAACTCAGAAGGG
TTTCAGATTGTCCATGTCCAGAAACAACAGTGTCTTTTCAAAAATGAGAAAGTGGTCGTG
GGCTCATGCAACAGGACCATCCAGAACCAGCAGTGGATGTGGACTGAGGATGAAAAGCTC
CTTCATGTTAAATCTGCACTGTGCTTGGCCATCTCCAACTCTTCCCGCGGCCCCTCCCGC
TCAGCCATCTTGGACCGCTGTTCCCAGGCACCCCGATGGACCTGCTATGATCAGGAAGGC
TTCCTTGAGGTGGAAAATGCCTCTCTCTTTCTCCAGAAACAAGGCTCCAGAGTAGTGGTC
AAGAAGGCCAGGAAATACCTCCATAGCTGGATGAAAATAGATGTCAACAAGGAGGGAAAA
CTGGTCAATGAAAGCCTCTGTTTACAAAAAGCTGGCCTGGGAGCAGAAGTTTCGGTGAGG
AGCACTAGAAACACGGCTCCACCCCAGATTCTCACTACCTTTAATGCAGTTCCAGATGGC
CTGGTATTCCTTATTAGGAATACCACAGAGGCCTTCATCAGAAATGCTGCAGAAAACTAC
AGCCAAAACAGCAGCGAGAGGCAGCATCCCAATCTGCACATGACTGGAATTACAGACACA
TCATGGGTTTTGTCGACTACTCAGCCCTTCTCCAGCACCACTGAAGAGACTGGACTGGCG
GAGCCAGAGAGATGTAACTTCACCCTGGCGGAGTCCAAGGCCTCCAGCCATTCTGTGTCT
ATCCAGTGGAGAATTTTGGGCTCACCCTGTAACTTTAGCCTCATCTATAGCAGTGACACC
CTGGGGGCCGCGTTGTGCCCTACCTTTCGGATAGACAACACCACATACGGATGTAACCTT
CAAGATTTACAAGCAGGAACCATCTATAACTTCAGGATTATTTCTCTGGATGAAGAGAGA
ACAGTGGTCTTGCAAACAGATCCTTTACCTCCTGCTAGGTTTGGAGTCAGTAAAGAGAAG
ACGACTTCAACCAGCTTGCATGTTTGGTGGACTCCTTCTTCCGGAAAAGTCACCTCATAT
GAGGTGCAATTATTTGATGAAAATAACCAAAAGATACAGGGGGTTCAAATTCAAGAAAGT
ACTTCATGGAATGAATACACTTTTTTCAATCTCACTGCTGGTAGTAAATACAATATTGCC
ATCACAGCTGTTTCTGGAGGAAAACGTTCTTTTTCAGTTTATACCAATGGATCAACAGTG
CCATCTCCAGTGAAAGATATTGGTATTTCCACAAAAGCCAATTCTCTCCTGATTTCCTGG
TCCCATGGTTCTGGGAATGTGGAACGATACCGGCTGATGCTAATGGATAAAGGGATCCTA
GTTCATGGCGGTGTTGTGGACAAACATGCTACTTCCTATGCTTTTCACGGGCTGACCCCT
GGCTACCTCTACAACCTCACTGTTATGACTGAGGCTGCAGGGCTGCAAAACTACAGGTGG
AAACTAGTCAGGACAGCCCCCATGGAAGTCTCAAATCTGAAGGTGACAAATGATGGCAGT
TTGACCTCTCTAAAAGTCAAATGGCAAAGACCTCCTGGAAATGTGGATTCTTACAATATC
ACCCTGTCTCACAAAGGGACCATCAAGGAATCCAGAGTATTAGCACCTTGGATTACTGAA
ACTCACTTTAAAGAGTTAGTCCCCGGTCGACTTTATCAAGTTACTGTCAGCTGTGTCTCT
GGTGAACTGTCTGCTCAGAAGATGGCAGTGGGCAGAACATTTCCAGACAAAGTTGCAAAC
CTGGAGGCAAACAATAATGGCAGGATGAGGTCTCTTGTAGTGAGCTGGTCGCCCCCTGCT
GGAGACTGGGAGCAGTATCGGATCCTACTCTTCAATGATTCTGTGGTGCTGCTCAACATC
ACTGTGGGAAAGGAAGAAACACAGTATGTCATGGATGACACGGGGCTCGTACCGGGAAGA
CAGTATGAGGTGGAAGTCATTGTTGAGAGTGGAAATTTGAAGAATTCTGAGCGTTGCCAA
GGCAGGACAGTCCCCCTGGCTGTCCTCCAGCTTCGTGTCAAACATGCCAATGAAACCTCA
CTGAGTATCATGTGGCAGACCCCTGTAGCAGAATGGGAGAAATACATCATTTCCCTAGCT
GACAGAGACCTCTTACTGATCCACAAGTCACTCTCCAAAGATGCCAAAGAATTCACTTTT
ACTGACCTGGTGCCTGGACGAAAATACATGGCTACAGTCACCAGTATTAGTGGAGACTTA
AAAAATTCCTCTTCAGTAAAAGGAAGAACAGTGCCTGCCCAAGTGACTGACTTGCATGTG
GCCAACCAAGGAATGACCAGTAGTCTGTTTACTAACTGGACCCAGGCACAAGGAGACGTA
GAATTTTACCAAGTCTTACTGATCCATGAAAATGTGGTCATTAAAAATGAAAGCATCTCC
AGTGAGACCAGCAGATACAGCTTCCACTCTCTCAAGTCCGGCAGCCTGTACTCCGTGGTG
GTAACAACAGTGAGTGGAGGGATCTCTTCCCGACAAGTGGTTGTGGAGGGAAGAACAGTC
CCTTCCAGTGTGAGTGGAGTAACGGTGAACAATTCCGGTCGTAATGACTACCTCAGCGTT
TCCTGGCTGCTGGCGCCCGGAGATGTGGATAACTATGAGGTAACATTGTCTCATGACGGC
AAGGTGGTTCAGTCCCTTGTCATTGCCAAGTCTGTCAGAGAATGTTCCTTCAGCTCCCTC
ACCCCAGGCCGCCTCTACACCGTGACCATAACTACAAGGAGTGGCAAGTATGAAAATCAC
TCCTTCAGCCAAGAGCGGACAGTGCCTGACAAAGTCCAGGGAGTCAGTGTTAGCAACTCA
GCCAGGAGTGACTATTTAAGGGTATCCTGGGTGCATGCCACTGGAGACTTTGATCACTAT
GAAGTCACCATTAAAAACAAAAACAACTTCATTCAAACTAAAAGCATTCCCAAGTCAGAA
AACGAATGTGTATTTGTTCAGCTAGTCCCTGGACGGTTGTACAGTGTCACTGTTACTACA
AAAAGTGGACAATATGAAGCCAATGAACAAGGGAATGGGAGAACAATTCCAGAGCCTGTT
AAGGATCTAACATTGCGCAACAGGAGCACTGAGGACTTGCATGTGACTTGGTCAGGAGCT
AATGGGGATGTCGACCAATATGAGATCCAGCTGCTCTTCAATGACATGAAAGTATTTCCT
CCTTTTCACCTTGTAAATACCGCAACCGAGTATCGATTTACTTCCCTAACACCAGGCCGC
CAATACAAAATTCTTGTCTTGACGATTAGCGGGGATGTACAGCAGTCAGCCTTCATTGAG
GGCTTCACAGTTCCTAGTGCTGTCAAAAATATTCACATTTCTCCCAATGGAGCAACAGAT
AGCCTGACGGTGAACTGGACTCCTGGTGGGGGAGACGTTGATTCCTACACGGTGTCGGCA
TTCAGGCACAGTCAAAAGGTTGACTCTCAGACTATTCCCAAGCACGTCTTTGAGCACACG
TTCCACAGACTGGAGGCCGGGGAGCAGTACCAGATCATGATTGCCTCAGTCAGCGGGTCC
CTGAAGAATCAGATAAATGTGGTTGGGCGGACAGTTCCAGCATCTGTCCAAGGAGTAATT
GCAGACAATGCATACAGCAGTTATTCCTTAATAGTAAGTTGGCAAAAAGCTGCTGGTGTG
GCAGAAAGATATGATATCCTGCTTCTAACTGAAAATGGAATCCTTCTGCGCAACACATCA
GAGCCAGCCACCACTAAGCAACACAAATTTGAAGATCTAACACCAGGCAAGAAATACAAG
ATACAGATCCTAACTGTCAGTGGAGGCCTCTTTAGCAAGGAAGCCCAGACTGAAGGCCGA
ACAGTCCCAGCAGCTGTCACCGACCTGAGGATCACAGAGAACTCCACCAGGCACCTGTCC
TTCCGCTGGACCGCCTCAGAGGGGGAGCTCAGCTGGTACAACATCTTTTTGTACAACCCA
GATGGGAATCTCCAGGAGAGAGCTCAAGTTGACCCACTAGTCCAGAGCTTCTCTTTCCAG
AACTTGCTACAAGGCAGAATGTACAAGATGGTGATTGTAACTCACAGTGGGGAGCTGTCT
AATGAGTCTTTCATATTTGGTAGAACAGTCCCAGCCTCTGTGAGTCATCTCAGGGGGTCC
AATCGGAACACGACAGACAGCCTTTGGTTCAACTGGAGTCCAGCCTCTGGGGACTTTGAC
TTTTATGAGCTGATTCTCTATAATCCCAATGGCACAAAGAAGGAAAACTGGAAAGACAAG
GACCTGACGGAGTGGCGGTTTCAAGGCCTTGTTCCTGGAAGGAAGTACGTGCTGTGGGTG
GTAACTCACAGTGGAGATCTCAGCAATAAAGTCACAGCGGAGAGCAGAACAGCTCCAAGT
CCTCCCAGTCTTATGTCATTTGCTGACATTGCAAACACATCCTTGGCCATCACGTGGAAA
GGGCCCCCAGACTGGACAGACTACAACGACTTTGAGCTGCAGTGGTTGCCCAGAGATGCA
CTTACTGTCTTCAACCCCTACAACAACAGAAAATCAGAAGGACGCATTGTGTATGGTCTT
CGTCCAGGGAGATCCTATCAATTCAACGTCAAGACTGTCAGTGGTGATTCCTGGAAAACT
TACAGCAAACCAATTTTTGGATCTGTGAGGACAAAGCCTGACAAGATACAAAACCTGCAT
TGCCGGCCTCAGAACTCCACGGCCATTGCCTGTTCTTGGATCCCTCCTGATTCTGACTTT
GATGGTTATAGTATTGAATGCCGGAAAATGGACACCCAAGAAGTTGAGTTTTCCAGAAAG
CTGGAGAAAGAAAAATCTCTGCTCAACATCATGATGCTAGTGCCCCATAAGAGGTACCTG
GTGTCCATCAAAGTGCAGTCGGCCGGCATGACCAGCGAGGTGGTTGAAGACAGCACTATC
ACAATGATAGACCGCCCCCCTCCTCCACCCCCACACATTCGTGTGAATGAAAAGGATGTG
CTAATTAGCAAGTCTTCCATCAACTTTACTGTCAACTGCAGCTGGTTCAGCGACACCAAT
GGAGCTGTGAAATACTTCACAGTGGTGGTGAGAGAGGCTGATGGCAGTGATGAGCTGAAG
CCAGAACAGCAGCACCCTCTCCCTTCCTACCTGGAGTACAGGCACAATGCCTCCATTCGG
GTGTATCAGACTAATTATTTTGCCAGCAAATGTGCCGAAAATCCTAACAGCAACTCCAAG
AGTTTTAACATTAAGCTTGGAGCAGAGATGGAGAGCCTAGGTGGAAAATGCGATCCCACT
CAGCAAAAATTCTGTGATGGACCACTGAAGCCACACACTGCCTACAGAATCAGCATTCGA
GCTTTTACACAGCTCTTTGATGAGGACCTGAAGGAATTCACAAAGCCACTCTATTCAGAC
ACATTTTTTTCTTTACCCATCACTACTGAATCAGAGCCCTTGTTTGGAGCTATTGAAGGT
GTGAGTGCTGGTCTGTTTTTAATTGGCATGCTAGTGGCTGTTGTTGCCTTATTGATCTGC
AGACAGAAAGTGAGCCATGGTCGAGAAAGACCCTCTGCCCGTCTGAGCATTCGTAGGGAT
CGACCATTATCTGTCCACTTAAACCTGGGCCAGAAAGGTAACCGGAAAACTTCTTGTCCA
ATAAAAATAAATCAGTTTGAAGGGCATTTCATGAAGCTACAGGCTGACTCCAACTACCTT
CTATCCAAGGAATACGAGGAGTTAAAAGACGTGGGCCGAAACCAGTCATGTGACATTGCA
CTCTTGCCGGAGAATAGAGGGAAAAATCGATACAACAATATATTGCCCTATGATGCCACG
CGAGTGAAGCTCTCCAATGTAGATGATGATCCTTGCTCTGACTACATCAATGCCAGCTAC
ATCCCTGGCAACAACTTCAGAAGAGAATACATTGTCACTCAGGGACCGCTTCCTGGCACC
AAGGATGACTTCTGGAAAATGGTGTGGGAACAAAACGTTCACAACATCGTCATGGTGACC
CAGTGTGTTGAGAAGGGCCGAGTAAAGTGTGACCATTACTGGCCAGCGGACCAGGATTCC
CTCTACTATGGGGACCTCATCCTGCAGATGCTCTCAGAGTCCGTCCTGCCTGAGTGGACC
ATCCGGGAGTTTAAGATATGCGGTGAGGAACAGCTTGATGCACACAGACTCATCCGCCAC
TTTCACTATACGGTGTGGCCAGACCATGGAGTCCCAGAAACCACCCAGTCTCTGATCCAG
TTTGTGAGAACTGTCAGGGACTACATCAACAGAAGCCCGGGTGCTGGGCCCACTGTGGTG
CACTGCAGTGCTGGTGTGGGTAGGACTGGAACCTTTATTGCATTGGACCGAATCCTCCAG
CAGTTAGACTCCAAAGACTCTGTGGACATTTATGGAGCAGTGCACGACCTAAGACTTCAC
AGGGTTCACATGGTCCAGACTGAGTGTCAGTATGTCTACCTACATCAGTGTGTAAGAGAT
GTCCTCAGAGCAAGAAAGCTACGGAGTGAACAAGAAAACCCCTTGTTTCCAATCTATGAA
AATGTGAATCCAGAGTATCACAGAGATCCAGTCTATTCAAGGCATTGA
Pdb标识
2AHS; 2H02; 2H03; 2H04; 2HC1; 2HC2; 2I3R; 2I3U; 2I4E; 2I4G; 2I4H; 2I5X