Thioredoxin
同义词
ADF; ATL-derived factor; SASP; Surface-associated sulphydryl protein; TRDX; TRX; TRX1
氨基酸序列
>lcl|BSEQ0008733|Thioredoxin
MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVD
DCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
一般功能
Protein disulfide oxidoreductase activity
具体功能
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
基因序列
>lcl|BSEQ0017575|Thioredoxin (TXN)
ATGGTGAAGCAGATCGAGAGCAAGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGAT
AAACTTGTAGTAGTTGACTTCTCAGCCACGTGGTGTGGGCCTTGCAAAATGATCAAGCCT
TTCTTTCATGATGTTGCTTCAGAGTGTGAAGTCAAATGCATGCCAACATTCCAGTTTTTT
AAGAAGGGACAAAAGGTGGGTGAATTTTCTGGAGCCAATAAGGAAAAGCTTGAAGCCACC
ATTAATGAATTAGTCTAA
Pdb标识
1AIU; 1AUC; 1CQG; 1CQH; 1ERT; 1ERU; 1ERV; 1ERW; 1M7T; 1MDI; 1MDJ; 1MDK; 1TRS; 1TRU; 1TRV; 1TRW; 1W1C; 1W1E; 2HSH; 2HXK; 2IFQ; 2IIY; 3E3E; 3KD0; 3M9J; 3M9K; 3QFA; 3QFB; 3TRX; 4LL1; 4LL4; 4OO4; 4OO5; 4POK; 4POL; 4POM; 4PUF; 4TRX